A5069376500- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Extracellular vesicles in disease
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- Microplastics and Plastic Pollution
- Sex work and related issues
- Agricultural and Food Sciences
- dental development and anomalies
- Pediatric health and respiratory diseases
- Migration, Aging, and Tourism Studies
- Soil Management and Crop Yield
- Education during COVID-19 pandemic
- Adolescent Sexual and Reproductive Health
- COVID-19 Clinical Research Studies
- Intergenerational Family Dynamics and Caregiving
- Seaweed-derived Bioactive Compounds
- Nanoparticles: synthesis and applications
- Dental Trauma and Treatments
- Lipid metabolism and biosynthesis
- Occupational Health and Safety in Workplaces
University of Coimbra
2019-2025
German Cancer Research Center
2022-2024
Heidelberg University
2022-2024
South African National Biodiversity Institute
2024
University of Johannesburg
2024
University of California, Davis
2023
Universidade Luterana do Brasil
2017
Diabetic foot ulcers (DFUs) are a devastating complication of diabetes, presenting limited treatment success rates due to their complex pathophysiology. Bone morphogenetic protein 7 (BMP7) confers tissue protective and regenerative functions, but its potential role in diabetic wound healing is unknown. The aim this study was investigate the effects topical BMP7 using streptozotocin-induced mouse model. expression markers progression were detected RT-PCR or immunohistochemistry. Overall,...
Polylactic acid (PLA), a biodegradable and biocompatible polymer produced from renewable resources, has been widely used as nanoparticulate platform for antigen drug delivery. Despite generally regarded safe, its immunotoxicological profile, when polymeric nanoparticle (NP), is not well-documented. Thus, this study intends to address gap, by evaluating the toxicity of two different sized PLA NPs (PLAA PLAB NPs), nanoprecipitation methods extensively characterized regarding their...
Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute syndrome coronavirus 2 (SARS-CoV-2), virus responsible for COVID-19, and incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends COVID-19 T1D.
Poly-ε-caprolactone (PCL) is a biodegradable polyester that has FDA and CE approval as medical device. Nonetheless, the lack of toxicity exhibited by polymer cannot be extrapolated to its nanomaterial conformation. Despite PCL-based NPs being widely studied in biomedical field for their advantages controlled drug delivery systems, little data describe PCL NPs' toxicity, particularly immunotoxicity. This work assessed different systems intended protein regarding immunotoxicity...
Despite increasing knowledge about small extracellular vesicle (sEV) composition and functions in cell-cell communication, the mechanism behind their biogenesis remains unclear. Here, we reveal for first time that sEV release into microenvironment are tightly connected with another important organelle, Lipid Droplets (LDs). The correlation was observed several human cancer cell lines as well patient-derived colorectal stem cells (CR-CSCs). Our results demonstrated external stimuli such...
ResumenAunque los antimicrobianos son grandes aliados en producción animal, su uso masivo ha contribuido a la aparición de antibiorresistencias. Además, cuando periodos supresión no se respetan, sus residuos
Abstract Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic social challenges. Therefore, early identification patients with high‐risk profile would be important to adequate treatment more successful health outcomes. This study explores risk assessment profiles for prognosis, using machine learning predictive approaches decision tree algorithms. Patients...
Abstract Despite an increasing gain of knowledge regarding small extracellular vesicle (sEV) composition and functions in cell-cell communication, the mechanism behind their biogenesis remains unclear. Here, we revealed for first time that sEV release into microenvironment are tightly connected with another important organelle: Lipid Droplets (LD). We have observed this correlation using different human cancer cell lines as well patient-derived colorectal stem cells (CR-CSCs). Our results...