A5082011930- Ion Channels and Receptors
- Cardiac electrophysiology and arrhythmias
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Ischemia and Reperfusion
- Phytochemicals and Antioxidant Activities
- Signaling Pathways in Disease
- Hormonal Regulation and Hypertension
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Estrogen and related hormone effects
- Acute Myocardial Infarction Research
- Bioactive Compounds and Antitumor Agents
- Magnesium in Health and Disease
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Ion Transport and Channel Regulation
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
Instituto de Biomedicina de Sevilla
2015-2024
Universidad de Sevilla
2015-2024
Junta de Andalucía
2022
Centro de Investigación en Red en Enfermedades Cardiovasculares
2019-2020
Centro de Investigación Biomédica en Red
2019
Instituto Politécnico Nacional
2018
Université Paris-Sud
2018
Inserm
2018
Université Paris-Saclay
2018
Laboratory Signaling and Cardiovascular Pathophysiology
2018
Orai1 plays a major role in store-operated Ca2+ entry (SOCE) triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and A (PKA)-dependent phosphorylation at Ser-27 Ser-30 or Ser-34, respectively, which shapes the responses to agonists. The calmodulin-activated adenylyl cyclase type 8 (AC8) was reported interact directly with Orai1, thus mediating dynamic interplay between Ca2+- cyclic adenosine monophosphate...
T-type Ca(2+) channels are expressed in the ventricular myocytes of fetal and perinatal heart, but normally downregulated as development progresses. Interestingly, however, these re-expressed adult cardiomyocytes under pathological conditions. We investigated low voltage-activated channel regulation hypoxia rat cardiomyocytes. Molecular studies revealed that induces upregulation Cav 3.2 mRNA, whereas 3.1 mRNA is not significantly altered. The effect on was time- dose-dependent, required...
Melatonin has been reported to induce effective reduction in growth and development a variety of tumors, including breast cancer. In triple-negative cancer (TNBC) cells, melatonin attenuates features, such as tumor apoptosis resistance, through number still poorly characterized mechanisms. One biological process that is important for TNBC cells store-operated Ca
The MR (mineralocorticoid receptor) antagonists belong to the current therapeutic armamentarium for management of cardiovascular diseases, but mechanisms conferring their beneficial effects are poorly understood. Part is because regulation L-type Cav1.2 Ca2+ channel expression, which generated by tissue-specific alternative promoters as a long cardiac or short vascular N-terminal transcripts.To analyze molecular aldosterone, through MR, modulates expression and function in manner.In primary...
Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense respond to a wide variety of physical chemical stimuli. As other TRP, TRPC may form homo or heterotetrameric ion channel, can associate with membrane receptors regulate intracellular calcium concentration. Dysfunctions involved many types cardiovascular diseases. Significant increase the expression different isoforms has been observed animal model...
Background Primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) improves the survival of patients; nevertheless, some develop left ventricular adverse remodeling (LVAR) a few months after intervention. The main objective this study was to characterize role pro-inflammatory cell populations, related cytokines, and microRNAs (miRNAs) released PPCI as reliable prognostic biomarkers for LVAR STEMI. Methods We evaluated level...
It is well established that abnormalities in [Ca2+] regulation occur heart diseases. Actually, independent studies demonstrated Orai1/2/3 and TRPC protein related with store-operated calcium channels (SOCC) have a role cardiac pathologies. Ischemia/reperfusion (I/R) stimulates transcription factor activation modifies the expression of genes implicated pathogenesis this process. Previous results described an increase Orai1 TRPC5 cardiomyocytes after I/R, although molecular mechanisms mediate...