A5072116674- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Ion channel regulation and function
- Cancer Treatment and Pharmacology
- Cardiac Fibrosis and Remodeling
- Phosphodiesterase function and regulation
- Electron Spin Resonance Studies
- Ion Transport and Channel Regulation
- Effects of Radiation Exposure
- Diamond and Carbon-based Materials Research
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Cardiovascular Effects of Exercise
- Metal complexes synthesis and properties
- Protein Kinase Regulation and GTPase Signaling
- Heat shock proteins research
- Carbon Nanotubes in Composites
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Hair Growth and Disorders
- Peptidase Inhibition and Analysis
- Neuroscience and Neural Engineering
- Chemotherapy-induced organ toxicity mitigation
Brown University
2025
Inserm
2009-2023
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
2011-2023
Université Paris-Sud
2009-2023
Université Paris-Saclay
2005-2023
Institut Galien Paris-Saclay
2008-2023
Laboratory Signaling and Cardiovascular Pathophysiology
2008-2022
Université Paris Cité
2022
Instituto Politécnico Nacional
2018
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2008-2014
Cardiac hypertrophy is promoted by adrenergic overactivation and can progress to heart failure, a leading cause of mortality worldwide. Although cAMP among the most well-known signaling molecules produced beta-adrenergic receptor stimulation, its mechanism action in cardiac not fully understood. The identification Epac (exchange protein directly activated cAMP) proteins as novel sensors for has broken dogma surrounding kinase A. However, their role regulation mature remain be defined. Here,...
cAMP is a powerful second messenger whose known general effector protein kinase A (PKA). The identification of binding protein, Epac, raises the question its role in Ca 2+ signalling cardiac myocytes. In this study, we analysed effects Epac activation on handling by using confocal microscopy isolated adult rat cardiomyocytes. [Ca ] i transients were evoked electrical stimulation and sparks measured quiescent was selectively activated analogue 8‐(4‐chlorophenylthio)‐2′‐ O...
cAMP is one of the most important second messenger in heart. The discovery Epac as a guanine exchange factor (GEF), which directly activated by cAMP, raises question role this protein cardiac cells. Here we show that activation leads to morphological changes and induces expression hypertrophic markers. This process associated with Ca2+-dependent small GTPase, Rac. In addition, found activates prohypertrophic signaling pathway, involves Ca2+ sensitive phosphatase, calcineurin, its primary...
Abstract Background In the realm of HIV care, CD4 monitoring guidelines serve as a cornerstone for managing health and treatment plans individuals living with HIV. Various authoritative bodies, including U.S. Department Health Human Services (HHS) offer nuanced tailored to latest research clinical best practices. our study, we aimed investigate frequency unnecessary testing assess healthcare providers' comfort level less frequent monitoring.Figure 1:Healthcare Provider Comfort Levels...
Aim Investigating long-term cardiac effects of low doses ionizing radiation is highly relevant in the context interventional cardiology and radiotherapy. Epidemiological data report that irradiation to heart can result significant increase cardiovascular mortality by yet unknown mechanisms. In addition co-morbidity factor such as hypertension or/and atherosclerosis enhance complications. Therefore, we explored mechanisms lead remodelling investigated interaction radiation-induced damage...
Background— Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signaling pathways. However, molecular mechanisms that negatively regulate these signal transduction pathways remain poorly understood. Methods Results— Here, we characterized Carabin, a protein expressed in cardiomyocytes was downregulated cardiac human failure. Four weeks after transverse aortic constriction, Carabin-deficient (Carabin −/− ) mice developed exaggerated...
To investigate whether the oxidative status of an 18:3(n-3) polyunsaturated fatty acid (PUFA)-enriched diet could modulate growth chemically induced rat mammary tumors, three independent experiments were performed. Experiments I and II examined variation tumor by addition antioxidant (vitamin E) or a prooxidant system (sodium ascorbate/2-methyl-1,4-naphthoquinone) to 15% linseed oil rich in 18:3(n-3). Experiment III addressed role PUFA modulation vitamin E. For this purpose, we compared...
The serotonin 5‐hydroxytryptamine (5‐HT 4 ) receptor is of potential interest for the treatment Alzheimer's disease because it increases memory and learning. In this study, we investigated effect zinc metalloprotease inhibitors on amyloid precursor protein (APP) processing induced by 5‐HT in vitro. We show that secretion non‐amyloidogenic form APP, sAPPα 4(e) isoform was not due to a general boost constitutive secretory pathway but rather its specific α‐secretase activity. Although h5‐HT...
The MR (mineralocorticoid receptor) antagonists belong to the current therapeutic armamentarium for management of cardiovascular diseases, but mechanisms conferring their beneficial effects are poorly understood. Part is because regulation L-type Cav1.2 Ca2+ channel expression, which generated by tissue-specific alternative promoters as a long cardiac or short vascular N-terminal transcripts.To analyze molecular aldosterone, through MR, modulates expression and function in manner.In primary...
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy heart failure. This study sought investigate role exchange protein directly activated by cAMP (EPAC) in Dox-induced potential cardioprotective effects EPAC inhibition. We show that Dox induces DNA damage cardiomyocyte cell death with apoptotic features. also led an...