Saturated fatty acids possess few health benefits compared to unsaturated acids. However, increasing experimental evidence demonstrates the nutritionally beneficial role of odd-chain saturated in human health. In this study, anti-cancer effects pentadecanoic acid were evaluated breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem properties parental MCF-7 cells. Pentadecanoic exerted selective cytotoxic MCF-7/SC Moreover, reduced...

Abstract Myricetin is a commonly found dietary flavonoid. In the present study, we investigated effects of myricetin on migration and invasion radioresistant lung cancer cells (A549‐IR). Transcriptome analysis A549‐IR identified several differentially expressed genes (DEGs) in compared to parental A549 cells. Functional enrichment revealed that most DEGs were linked with PI3K‐AKT signaling, proteoglycans, focal adhesion, ECM–receptor interactions. demonstrated enhanced migratory potential...

Abstract The Folch method is a commonly employed, simple biochemical procedure used to extract fat from food items and biological samples in biochemistry laboratories. iodine number of reflects its degree unsaturation. In the present study, extracted using cow milk, goat chicken egg yolk coconut milk was determined colorimetric that comprises an solution ethanol starch solution, replacing Wijs reagent conventional titration procedures with sodium thiosulfate standard solutions. Resembling...

The present study investigated the potential anticancer activity of bark Mangifera zeylanica, an endemic plant in Sri Lanka that has been traditionally used for cancer therapy. Cytotoxic and apoptotic effects were vitro using sulphorodamine assay, acridine orange ethidium bromide staining, caspase‑3 ‑7 activity, DNA fragmentation reverse transcription‑quantitative polymerase chain reaction estrogen receptor positive MCF‑7 triple‑negative MDA‑MB‑231 breast cell lines, SKOV‑3 ovarian line...

Resistance to chemotherapy and radiation therapy is considered a major therapeutic barrier in breast cancer. Cancer stem cells (CSCs) play prominent role chemo radiotherapy resistance. The established radio-resistant triple-negative cancer (TNBC) cell line MDA-MB-231/IR displays greater CSC characteristics than the parental MDA-MB-231 cells. Escalating evidence demonstrates that metadherin (MTDH) associated with number of signaling pathways as well resistance, making it an attractive target....

Overcoming chemo‑ and radio‑resistance is a major challenge in pancreatic cancer treatment. Therefore, there an urgent need to discover novel therapeutic approaches avoid cancer. Catechol phytochemical found some fruits vegetables. A few studies have reported on the potential anticancer effects of pure catechol. The present study aimed explore radio‑sensitizing catechol Panc‑1 human cells. cell proliferation, clonogenic survival, invasion, migration were assessed using MTT, migration,...

Estrogen receptors are indicators of breast cancer adaptability to endocrine therapies, such as tamoxifen. Deficiency or absence estrogen receptor α (ER-α) in cells results reduced efficacy therapy. Here, we investigated the effect combined tamoxifen and pentadecanoic acid therapy on ER-α-under-expressing cells. Drug resistance gene expression patterns were determined by RNA sequencing analysis vitro experiments. For first time, demonstrate that treatment acid, an odd-chain fatty...

Bananas, one of the most widely consumed fruits worldwide, are a rich source valuable phytochemicals. In this study, antioxidant and anticancer potential banana flesh was investigated. Of four kinds extracts, hexane extract (HE) had highest total polyphenol content (2.54 ± 0.60 mg GAE/g) flavonoid (1.69 0.34 RE/g), followed by chloroform fraction, ethanol extract, fraction. HE found to exert strong radical scavenging activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH•)...

Gedunin is one of the major compounds found in neem tree (Azadirachta indica). In present study, antiproliferative potential gedunin was evaluated human embryonal carcinoma cells (NTERA-2, a cancer stem cell model) and peripheral blood mononuclear (PBMCs), using Sulforhodamine (SRB) WST-1 assays, respectively. The effects on expression heat shock protein 90 (HSP90), its cochaperone Cdc37, HSP client proteins (AKT, ErbB2, HSF1) were by real-time PCR. Effects apoptosis (a) associated...

10-Gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic nature, lipids have ability to incorporate into cell membranes and modulate membrane properties. The purpose present study was evaluate effects 10-gingerol on raft/membrane raft modulation radio-resistant triple negative breast cancer (MDA-MB-231/IR) cells. MDA-MB-231/IR cells’ proliferation, clonogenic growth, migration, invasion were assayed using MTT, colony formation, assays,...

The biomolecules offer different metal-binding sites to form a coordination polymer with structural diversity. directed one-dimensional metal-biomolecule nanofibers (Cu-Asp NFs) designed using copper as metal ion and aspartate ligand for triboelectric nanogenerator (TENG) is reported here. characterization techniques reveal the detailed characteristics of synthesized Cu-Asp NFs. robust coating NFs achieved simple tape cast coater. bending water dipping studies suggest stability coated...

We investigated the effects of cooking (steaming and microwaving) processing (freeze-drying hot-air-drying) methods on antioxidant activity broccoli florets. 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•), alkyl• free radical scavenging assays were employed to assess anti-oxidant potentials. The cytoprotective effect against oxidative damage induced by H2O2 was studied using hepatocellular carcinoma (HepG2) cells. Anti-proliferative...

Current breast cancer therapies have limitations in terms of increased drug resistance resulting short-term efficacy, thus demanding the discovery new therapeutic agents. In this study, cytotoxic activity and apoptotic effects govaniadine isolated from Corydalis govaniana Wall. roots were determined on human (MCF-7) cells. The SRB assay result revealed that led to dose- time-dependent effect MCF-7 cells along with less cytotoxicity against MCF-10A Govaniadine-induced apoptosis was also...

Abstract Cow milk is a widely consumed liquid diet, and its fatty acid composition impacts nutritional biochemical properties. However, research on the anticancer efficacy of cow milk-derived fat in liver cancer cells limited. This study investigated antiproliferative apoptotic effects human hepatoma HepG2 cells. Additionally, cell cycle progression Janus kinase (JAK)-2/signal transducer activator transcription (STAT)-3 signaling were assessed. Furthermore, histone deacetylase inhibitory...

Lung cancer is the major cause of death among men. A number natural compounds have proven to be useful in treatmet lung cancer. This study was aimed determine cytotoxic and apoptotoic effects a compound 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO) isolated from Schumacheria castaneifolia non-small-cell (NCI-H292) cells. Cytotoxic 3-O-L-AO were determined by Sulforhodamine B (SRB) assay apoptotic tested evaluating (a) apoptotsis related morphological changes, (b) caspase 3/7 activity, (c)...

In this study, in vitro cytotoxic and apoptotic effects of the organic extracts (hexane, chloroform, ethyl acetate methanol) Mangifera zeylanica fruit peel flesh on estrogen receptor positive MCF-7 cancer cells were examined. Chloroform extract was found to be (IC50 78.46 ± 1.7 µg/mL) while none cytotoxic. Caspase 7 activity increased DNA fragmentation as well morphological features apoptosis shown by acridine orange/ethidium bromide Hoechst (33258) staining occurred response chloroform...