A5103216142- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Analytical Chemistry and Chromatography
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Analysis
- Analytical chemistry methods development
- Alkaloids: synthesis and pharmacology
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Chromatography in Natural Products
- Analytical Methods in Pharmaceuticals
- Drug-Induced Hepatotoxicity and Protection
- Psychedelics and Drug Studies
- Berberine and alkaloids research
- Mass Spectrometry Techniques and Applications
- Hormonal and reproductive studies
Shanghai Medical College of Fudan University
2015-2021
Center for Life Sciences
2021
Peking University
2021
Fudan University
2014-2019
Second Military Medical University
2014
The lack of systematic studies on the stability ethanol's non-oxidative metabolites in postmortem specimens restricts their use forensic cases. This study aimed to compare ethyl glucuronide (EtG), sulfate (EtS), phosphatidylethanols (PEths) and fatty acid esters (FAEEs) human blood. Three groups were established based level source ethanol: blank group, ethanol-spiked group ethanol-positive group. Each contained six blood samples from different corpses. each placed at 37, 25, 4 −20°C. Every...
A rapid, simple and sensitive liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed for the qualitative quantitative analysis of nine barbiturates (barbital, phenobarbital, pentobarbital, amobarbital, secobarbital, thiopental, butalbital, butabarbital, hexobarbital) in human whole blood. Barbiturates were extracted from 100 μL blood samples using a liquid‐liquid extraction (LLE) procedure, detected by LC‐MS/MS. An UPLC C18 (2.1 mm × mm, 1.7 µm) column used at 40 °C...
N-Ethylpentylone (NEP) is a popular synthetic cathinone abused worldwide. To obtain more information about its pharmacokinetics and pharmacodynamics, rapid, simple sensitive liquid chromatography-tandem mass spectrometry method was developed for the determination of NEP, two important neurotransmitters, dopamine serotonin, their metabolites, including 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine 5-hydroxyindole-3-acetic in rat brain microdialysate. The analytes were separated on...
Abstract N‐Ethylpentylone (NEP) is one of the most confiscated synthetic cathinones in world. However, its pharmacology and pharmacokinetics remain largely unknown. In this study, pharmacokentics NEP rat nucleus accumbens (NAc) was assessed via brain microdialysis after intraperitoneal (ip) administration (20 or 50 mg/kg). The concentrations dopamine (DA) serotonin (5‐HT) their metabolites, including 3,4‐dihydroxyphenylacetic acid (DOPAC), 3‐methoxytyramine (3‐MT), 5‐hydroxyindoleacetic...
N -ethylpentylone (NEP), a new synthetic cathinone, has been rising to be one of the most popular cathinone derivatives in recent years. However, research on NEP is rather limited. In this study, locomotor stimulation and sensitization, as well anxiety-like behavior induced by were studied Sprague-Dawley rats, using open field elevated plus maze respectively. Rats administered (5, 20 or 50 mg/kg, intraperitoneal), with saline negative control methamphetamine (5 mg/kg) positive control. Acute...
Liquid–liquid extraction (LLE) is the most commonly sample preparation procedure used by forensic toxicologists in China for screening drugs whole human blood. It extracts numerous substances from blood including targeted and interfering substances, specifically triglycerides (TG). With increasing prevalence of hyperlipidemia, influences TG on LLE subsequent analysis with gas chromatography–mass spectrometry (GC–MS) may become a major issue laboratories. This study aims to elucidate provide...
Background: Dopamine transporter (DAT) and serotonin (SERT) are targets for many psychoactive substances. Functional assays including uptake inhibition release often involve radiolabeled compounds like [ 3 H]-dopamine H]-serotonin to assess drug activity at transporters, which have high requirements on handling radioactive samples. Aims: The aim of this study was establish a label-free method DAT SERT. Methods: A liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)...
Artemisiae Argyi Folium is commonly used in clinical practice. Verlotori Folium, the dried leaves of Artemisia verlotorum, often as a folk substitute for Lingnan area. In this study, gas chromatography-triple quadrupole mass spectrometry(GC-MS) was to detect volatile oil components 27 samples and 13 were compared between two species. The internal standard method combined with multi-reaction monitoring mode(MRM) determine content six major components. Hierarchical clustering analysis(HCA)...