A5012802052- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- COVID-19 epidemiological studies
- Poisoning and overdose treatments
- Cardiac Arrest and Resuscitation
- Prenatal Substance Exposure Effects
- Thyroid Cancer Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 impact on air quality
- Misinformation and Its Impacts
- COVID-19 Pandemic Impacts
- Clinical Laboratory Practices and Quality Control
- BRCA gene mutations in cancer
- Healthcare cost, quality, practices
- Mental Health Research Topics
- Interpreting and Communication in Healthcare
- Healthcare Operations and Scheduling Optimization
- Pain Management and Opioid Use
- Infection Control and Ventilation
- Primary Care and Health Outcomes
- demographic modeling and climate adaptation
- Thyroid and Parathyroid Surgery
- Meta-analysis and systematic reviews
- Explainable Artificial Intelligence (XAI)
Harvard University
2020-2023
Massachusetts General Hospital
2020-2023
Food and Drug Administration
2023
United States Food and Drug Administration
2023
Massachusetts Institute of Technology
2023
Veterans Health Administration
2023
Stanford Medicine
2023
MGH Institute of Health Professions
2022
Beth Israel Deaconess Medical Center
2021
Center for Assessment
2020
BackgroundUnderstanding how environmental factors affect SARS-CoV-2 transmission could inform global containment efforts. Despite high scientific and public interest multiple research reports, there is currently no consensus on the association of transmission. To address this gap, we aimed to assess relative risk associated with weather conditions ambient air pollution.MethodsIn analysis, adjusted for delay between infection detection, estimated daily reproduction number at 3739 locations...
The opioid crisis is a major public health challenge in the United States, killing about 70,000 people 2020 alone. Long delays and feedbacks between policy actions their effects on drug-use behavior create dynamic complexity, complicating decision-making. In 2017, National Academies of Sciences, Engineering, Medicine called for quantitative systems model to help understand address this complexity guide decisions. Here, we present SOURCE (Simulation Opioid Use, Response, Consequences,...
Introduction Alongside the emergence of COVID-19 in United States, several reports highlighted increasing rates opioid overdose from preliminary data. Yet, little is known about how state-level death trends and decedent characteristics have evolved using official records.Methods We requested vital statistics data 2018–2020 all 50 states District Columbia, receiving 14 states. Accounting for COVID-19, we excluded without past March 2020, leaving 11 analysis. defined state-specific analysis...
Opioid overdose deaths remain a major public health crisis. We used system dynamics simulation model of the U.S. opioid-using population age 12 and older to explore impacts 11 strategies on prevalence opioid use disorder (OUD) fatal overdoses from 2022 2032. These spanned misuse OUD prevention, buprenorphine capacity, recovery support, harm reduction. By 2032, three saved most lives: (i) reducing risk involving fentanyl use, which may be achieved through fentanyl-focused reduction services;...
Abstract Background Understanding and projecting the spread of COVID-19 requires reliable estimates how weather components are associated with transmission virus. Prior research on this topic has been inconclusive. Identifying key challenges to estimation impact we study question using one largest assembled databases infections weather. Methods We assemble a dataset that includes virus data across 3,739 locations from December 12, 2019 April 22, 2020. Using simulation, identify impacts...
Background: The American Thyroid Association (ATA) published the 2015 Management Guidelines for patients with thyroid nodules and differentiated cancer, recommending a shift to less aggressive diagnostic, surgical, postoperative treatment strategies. At same time perhaps related new guidelines, there has been outpatient surgery. aim of current study was assess physician adherence these recommendations by identifying quantifying temporal trends in rates indications procedures inpatient...
Understanding how environmental factors impact COVID-19 transmission informs global containment efforts. We studied the relative risk of due to weather and ambient air pollution. estimated daily reproduction number at 3,739 locations, controlling for delay between infection detection, associating those with local conditions Controlling location-specific fixed effects policies, we found a negative relationship temperatures above 25oC, U-shaped outdoor ultraviolet exposure, weaker positive...
Because buprenorphine treatment of opioid use disorder reduces overdose deaths (OODs), expanding access to care is an important policy and clinical goal. Policymakers must choose within capacity limitations whether expand the number people with who are treated or extend duration for existing patients. This inherent tradeoff could be made less acute expanded capacity.To inform such decisions, we used a validated simulation model project effects increasing treatment-seeking, average episode...
Buprenorphine is an effective and cost-effective medication to treat opioid use disorder (OUD), but not readily available many people with OUD in the US. The current cost-effectiveness literature does consider interventions that concurrently increase buprenorphine initiation, duration, capacity.To conduct a analysis compare associated increased treatment capacity.This study modeled effects of 5 individually combination using SOURCE, recent system dynamics model prescription illicit use,...
Abstract In 2020, the ongoing US opioid overdose crisis collided with emerging COVID-19 pandemic. Opioid deaths (OODs) rose an unprecedented 38%, due to a combination of disrupting services essential people who use drugs, continued increases in fentanyls illicit drug supply, and other factors. How much did these factors contribute increased OODs? We used validated simulation model crisis, SOURCE, estimate excess OODs 2020 distribution that attributable various Factors affecting could have...
Intestinal campylobacteriosis, caused by Campylobacter ingestion, is the most reported zoonosis in EU; it societally costly and can lead to more severe sequelae. To reduce infections, biosecurity measures at both farms slaughterhouses are warranted. However, potential improvements achieved these interventions have not been quantified. We used a systems science approach develop simulation model, synthesizing information from interviews with stakeholders Dutch broiler production industry...
As the COVID-19 pandemic has caused major societal unrest, modelers have worked to project future trends of and predict upcoming challenges impacts policy action. These models, alone or in aggregate, are influential for decision-makers at every level. Therefore, method documentation models must be highly transparent ensure that projections consequential policies put forth sound epistemological grounds. We evaluated 29 receiving high attention levels within scientific community and/or...
Abstract As the COVID-19 pandemic has caused major societal unrest, modelers have worked to project future trends of and predict upcoming challenges impacts policy action. These models, alone or in aggregate, are influential for decision-makers at every level. Therefore, method documentation models must be highly transparent ensure that projections consequential policies put forth sound epistemological grounds. We evaluated 29 receiving high attention levels within scientific community...
Abstract Background Reports analyzing drug overdose (OD) mortality data during the COVID-19 pandemic are limited. Outcomes across states heterogenous, necessitating assessments of associations between and OD deaths on a state-by-state level. This report aims to analyze trends in Massachusetts COVID-19. Methods Analyzing 3,924 death records, we characterize opioid-, cocaine-, amphetamine-involved substance co-presence from March 24-November 8 2020 as compared 2018 2019. Results involving...