A5081009261- Organophosphorus compounds synthesis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phosphorus compounds and reactions
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- Advanced biosensing and bioanalysis techniques
- Enzyme Catalysis and Immobilization
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Synthetic Organic Chemistry Methods
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and properties of polymers
- Synthesis and Reactions of Organic Compounds
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- HIV/AIDS drug development and treatment
- Synthesis and Catalytic Reactions
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Cyclopropane Reaction Mechanisms
Massachusetts Institute of Technology
2024
Johns Hopkins University
2024
Kwansei Gakuin University
2024
University of British Columbia
2024
University of Rochester
2024
Osaka University
2024
National Tsing Hua University
2024
Tokyo Institute of Technology
2024
Columbia University
2024
RIKEN
2019-2023
Abstract Enzyme biosensors are useful tools that can monitor rapid changes in metabolite levels real-time. However, current approaches largely constrained to metabolites within a limited chemical space. With the rising development of artificial metalloenzymes (ArM), unique opportunity exists design from ground-up for difficult detect using technologies. Here we present and ArM ethylene probe ( AEP ), where an albumin scaffold is used solubilize protect quenched ruthenium catalyst. In...
Considering the intrinsic toxicities of transition metals, their incorporation into drug therapies must operate at minimal amounts while ensuring adequate catalytic activity within complex biological systems. As a way to address this issue, study investigates design synthetic prodrugs that are not only tuned be harmless, but can robustly transformed in vivo reach therapeutically relevant levels. To accomplish this, retrosynthetic prodrug highlights potential naphthylcombretastatin-based...
The direct synthesis of drugs in vivo enables to treat diseases without causing side effects healthy tissues. Transition-metal reactions have been widely explored for uncaging and synthesizing bioactive biological environments because their remarkable reactivity. Nonetheless, it is difficult develop a promising method achieve drug blood cells metabolites deactivate transition-metal catalysts. We report that robust albumin-based artificial metalloenzyme (ArM) with low loading (1-5 mol%) can...
HeLa cancer cells in mice can be tagged vivo with therapeutic moieties, thereby disrupting either tumor onset or growth.
Abstract In recent years, artificial metalloenzymes (ArMs) have become a major research interest in the field of biocatalysis. With ability to facilitate new-to-nature reactions, researchers generally prepared them either through intensive protein engineering studies or introduction abiotic transition metals. The aim this review will be summarize types ArMs that been recently developed, as well highlight their general reaction scope. A point emphasis also made discuss promising ways...
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