A5028224178- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- Advanced Fluorescence Microscopy Techniques
- Epigenetics and DNA Methylation
- Calcium signaling and nucleotide metabolism
- Cell Adhesion Molecules Research
- Protein Kinase Regulation and GTPase Signaling
- Mathematical Biology Tumor Growth
- Ubiquitin and proteasome pathways
- Bioactive Compounds and Antitumor Agents
- Cell Image Analysis Techniques
- Liver physiology and pathology
- Chemokine receptors and signaling
- Photoacoustic and Ultrasonic Imaging
- Fibroblast Growth Factor Research
- Photodynamic Therapy Research Studies
- Renal and related cancers
University of Illinois Chicago
2021-2025
Illinois College
2024
University of Illinois Urbana-Champaign
2024
Memorial Sloan Kettering Cancer Center
2016-2021
Harvard University
2010-2013
Receptor tyrosine kinases limit their own activity by stimulating that promote trafficking of the receptors to lysosome.
Three-dimensional (3D) optical microscopy permits in situ interrogation of the tumor microenvironment (TME) volumetric tumors for research while light sheet and confocal fluorescence are often used to achieve macroscopic microscopic 3D images tissues, respectively. Although each technique offers distinct fields view (FOVs) spatial resolution, combination two obtain correlative multiscale from same tissues has not yet been explored. We established a workflow that enables tracking imaging...
Epithelial transformation and carcinogenesis are characterized by profound alterations in cell mechanics that significantly affect multiple steps of the metastatic cascade. The ability cancer cells to grow primary tumor, locally invade through confining extracellular matrix, survive circulation, extravasate into distant vital organs all depend on specific mechanical characteristics. Importantly, recent studies have shown properties also influence their interactions with immune stromal cells....
Breast cancer progression and metastasis involve the action of multiple transcription factors in tumors cells tumor microenvironment (TME) understanding how these are coordinated can guide novel therapeutic strategies. Myocardin related A B (MRTFA/B) two that redundantly control cell invasion mouse models breast cancer, but their roles human incompletely understood. Here, we used a combination multiplexed immunofluorescence bioinformatics analyses to show MRTFA/B concurrently activated...
Three-dimensional (3D) optical microscopy, combined with advanced tissue clearing, permits
Abstract Breast cancer, the second highest cause of cancer-related deaths in women, accounts for 31% female cancer diagnoses. African American women have lower survival rates than White influenced by both biological factors (age, family history, genetic factors, tumor biology) and social determinants (socio-economic status, insurance health care access). However, precise remain unclear. The primary reason breast mortality is metastasis to organs like lung, liver, brain, with transcription...
Abstract Metastasis in breast cancer is a major challenge for prognosis and effective treatment, primarily because cells can create an immune-suppressive microenvironment that supports their progression spread. The physical properties of significantly influence metastatic potential interaction with the environment. Identifying targets impact both characteristics cells, crucial tackling disease. Interferon-stimulated gene 15 (ISG15), ubiquitin-like protein, often overexpressed tissues...
ABSTRACT Immune cells identify cancer by recognizing characteristic biochemical features indicative of oncogenic transformation. Cancer have mechanical features, as well, but whether these biophysical properties also contribute to destruction the immune system is not known. In present study, we found that enhanced expression myocardin related transcription factors (MRTFs), which promote migration and metastatic invasion, paradoxically compromised lung colonization melanoma breast carcinoma...
Metastases are responsible for majority cancer related deaths. Disseminated tumor cells (DTCs) gain a diverse array of metastatic traits in order to adapt and survive within different microenvironments, making them very difficult therapeutically target. Remarkably, regardless the secondary organ, DTCs thrive perivascular niches. Using xenograft syngeneic models metastasis mouse, we found that upon extravasation, neuronal cell adhesion molecule L1 (L1CAM) expressed by engages vascular basal...