A5101549351- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Antifungal resistance and susceptibility
- Medical and Biological Ozone Research
- Extracellular vesicles in disease
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Hepatitis Viruses Studies and Epidemiology
- Fungal Infections and Studies
- Mycotoxins in Agriculture and Food
- Cell death mechanisms and regulation
- HIV Research and Treatment
- Bee Products Chemical Analysis
- Bioactive Natural Diterpenoids Research
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Drug-Induced Adverse Reactions
- Reproductive tract infections research
- Brucella: diagnosis, epidemiology, treatment
Harbin Medical University
2012-2024
Sir Run Run Shaw Hospital
2012-2022
Zhejiang University
2012-2022
Heilongjiang University
2011
Education Department of Heilongjiang Province
2010-2011
Colorectal cancer (CRC) is the third most common malignant tumor in world. Previous research has shown that Lacticaseibacillus paracasei strains and its cultures have anti-colon effects, but study of L. paracasei-derived extracellular vesicles (LpEVs) as intercellular communication molecule against colon not been previously reported. Our showed LpEVs were taken by colorectal cells. Subsequently, inhibited proliferation, migration, invasion promote apoptosis growth CRC xenograft nude mice...
Aims: Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 have antiproliferative activity of colon cells, but the effect on glycolytic metabolism cancer cell remains enigmatic. The authors investigated how extracellular (LpEVs) inhibit growth cells by affecting tumor metabolism. Materials & methods: HCT116 were treated with LpEVs and then differentially expressed genes analyzed transcriptome sequencing, sequencing results confirmed in vivo vitro. Results: entered inhibited their...
The safety and immunogenicity of a personalized neoantigen-based peptide vaccine, iNeo-Vac-P01, was reported previously in patients with variety cancer types. current study investigated the synergistic effects radiofrequency ablation (RFA) neoantigen vaccination tumor-bearing mice.Twenty-eight were enrolled this study, including 10 who had received RFA treatment within 6 months before (Cohort 1), 18 not 2). Individualized vaccines designed, manufactured, subcutaneously administrated GM-CSF...
Abstract Occult HBV infection is defined as the persistence of DNA in individuals negative for surface antigen (HBsAg), and many different mechanisms have been reported countries. However, China, one endemic areas infection, no reports published on occult infection. The present study investigated virological features mechanism China. Full‐length from eight patients with (S1–S8) three HBsAg‐positive cases (SWT1–SWT3) was cloned sequenced. Additionally, four entire linear genomes were...
Necrostatin-1 (Nec-1) inhibits necroptosis by allosterically inhibiting the kinase activity of receptor-interacting protein 1 (RIP1), which plays a critical role in necroptosis. RIP1 is crucial adaptor involved activation NF-κB, production reactive oxygen species (ROS) and phosphorylation mitogen activated kinases (MAPKs). ROS MAPKs all play important roles apoptotic signaling. Nec-1 was regarded as having no effect on apoptosis. Here, we report that increased rate nuclear condensation...
ABSTRACT Human papillomavirus type 16 (HPV 16) plays a cardinal role in the pathogenesis of cervical cancer. HPV has intratypic variants which show different geographical distributions and oncogenic potentials. To analyze presence sequence variations northeast China, 71 carcinomas were identified by typing. 16-positive specimens analyzed PCR-directed sequencing E6, E7, L1 genes LCR (long control region). The variation data compared with those neighboring districts. In this hospital-based...
Hepatitis B virus (HBV) infection is responsible for 50% of liver cancer cases globally; this disease one the leading causes cancer‑associated mortality. One reported mechanism underlying development mutation tumor suppressor genes induced by overexpression apolipoprotein mRNA‑editing enzyme catalytic subunit 2 (APOBEC2) in hepatocytes. In addition, it has been observed that HBV inhibited microRNA (miR)‑122 expression hepatocytes; however, molecular mechanisms involved remain unknown and...
Abstract Honey is thought to act against microbes and regulates microbiota balance, this mainly attributed the enzymatic production of hydrogen peroxide, high osmolarity, nonperoxidase factors, for example, lysozyme botanical sources nectar, while effect honey's probiotic recently considered. The study honey as source beneficial understudied. purpose was screen microorganisms in with antagonistic property important pathogens mechanism antimicrobial activity thus play a role probiotics....
Colorectal cancer is one of the most common malignant cancers worldwide. Since colon cells rely on glycolysis as their major energy source, glycolytic metabolism has become a problem for therapy. Lacticaseibacillus paracasei anti-colon effects, and its secreted extracellular vesicles involved in intercellular communication can induce cell apoptosis, but effect remains enigmatic. Our findings demonstrate that LpEVs were ingested by colorectal prevent proliferation cells. treatment altered...
Summary. Understanding the consequences of mutation in tyrosine–methionine–aspartate–aspartate (YMDD) motif hepatitis B virus (HBV) genome on replication is critical for treating chronic with lamivudine. Allele-specific gene silencing by RNAi (allele-specific RNAi: ASP-RNAi) an advanced application techniques. Use this strategy as a means specifically inhibiting allele expression interest suggested that it can suppress alleles causing disease without corresponding wild-type alleles. However,...
Objective To investigate the prevalence of occult HBV infection among cryptogenic chronic liver disease patients and hepatitis B surface antigen (HBsAg) negative hepatocellular carcinoma (HCC) in north China.Methods The DNA 393 sera samples collected from (215),HBsAg (178) were tested by nested PCR.We performed real-time PCR to determine levels serum HBV-DNA.Results Prevalence was 23.7％ (51/215) 68.5％ (122/178) patients,HBsAg-negative HCC patients,respectivly.The IgG anti-HBc-positive...