A5061550454- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Ferrocene Chemistry and Applications
- Ginseng Biological Effects and Applications
- Photochromic and Fluorescence Chemistry
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Supramolecular Self-Assembly in Materials
- Diet and metabolism studies
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Fungal Biology and Applications
- Infectious Diseases and Mycology
- Helicobacter pylori-related gastroenterology studies
Inserm
2018-2023
Nantes Université
2020-2023
Immunologie et Nouveaux Concepts en Immunothérapie
2023
Université d'Angers
2018-2022
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2021
Micro et Nanomédecines translationnelles
2017-2019
Canadian Nautical Research Society
2018
Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans , etiological agent Buruli ulcer. Its involvement in lesion development has been widely described early stages disease, through its cytotoxic and immunosuppressive activities, but less known about later stages. Here, we revisit role mycolactone disease outcome provide first demonstration pro-inflammatory potential this toxin. We found that mycolactone-containing mycobacterial extracellular vesicles...
By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission pain signals. However, costs, animal handling ethical issues have reduced their dissemination routine use. Here we report LAKI (Light Activated K+ channel Inhibitor), a specific photoswitchable inhibitor pain-related two-pore-domain potassium TREK TRESK channels. In dark or ambient light, is inactive. alternating transdermal illumination at 365 nm 480...
Preferential internalization into GBM cells and significant decrease of the tumor volume by functionalized LNCs.
We demonstrate the production of skin-specific antibodies with neutralizing activity against mycolactone toxin.
Buruli ulcer is a neglected tropical disease caused by M. ulcerans, an environmental mycobacterium. This cutaneous infectious affects populations with poor access to sanitation, safe water and healthcare living in rural areas of West Central Africa. Stagnant open bodies surface slow-running streams are the only risk factor identified Africa, there no human-to-human transmission. Appropriate effective prevention strategies required for endemic areas. Based on multidisciplinary approach area...
Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and third most common mycobacterial worldwide. Without early treatment, M. provokes massive skin ulcers, caused by mycolactone toxin, its main virulence factor. However, spontaneous healing may occur in ulcer patients several months or years after onset. We have shown, an original mouse model, that bacterial load remains high viable spontaneously healed tissues, with switch to low levels production,...
Buruli ulcer is a chronic infectious disease caused by Mycobacterium ulcerans . The pathogen persistence in host skin associated with the development of ulcerative and necrotic lesions leading to permanent disabilities most patients. However, few diagnosed cases are thought resolve through an unknown self-healing process. Using vitro vivo mouse models M purified vesicles mycolactone, we showed that innate immune tolerance was only specific macrophages from mice able heal spontaneously. This...
Abstract Ketogenic diets have been used to treat diverse conditions, and there is growing evidence of their benefits for tissue repair in inflammatory disease treatment. However, role infectious diseases has little studied. Buruli ulcer (Mycobacterium ulcerans infection) a chronic characterized by large skin ulcerations caused mycolactone, the major virulence factor bacillus. In current study, we investigated impact ketogenic diet on this cutaneous an experimental mouse model. This prevented...