Esophageal cancer (EC) is one of the most common cancers worldwide. The cancer-related inflammation pathway- signal transducer and activator transition 3 (STAT3) signaling pathway has been reported to play critical role in its initiation progression, while way mediated hyperactivation remains elusive so far. Accumulating studies important microRNAs (miRNAs) regulation gene expression, among which, miR-124/STAT3 interaction widely various cancers, EC not investigated yet. Firstly, we...

Abstract Background This study was to explore the relationship between chronic constipation, diarrhea, and frailty in older Americans. Methods cross-sectional selected a total of 4241 community-dwelling individuals aged 60 years from 2005–2010 National Health Nutrition Examination Survey. Frailty measured using 49-item index, index > 0.21 defined as frail status. Chronic constipation diarrhea were “usual or most common type stool” by Bristol Stool Form Scale (BSFS) Types 1 2 BSFS 6 7,...

Abstract Background Visceral hypersensitivity is one of the main pathogenesis irritable bowel syndrome (IBS) and mast cell activation closely related to visceral hypersensitivity. As a critical molecule innate immune system, toll‐like receptor 4 (TLR4) may modulate cell. Alleviating effect electroacupuncture (EA) on has been proved, whereas, whether TLR4 involved in this process remains unclear. Methods Forty Sprague‐Dawley rats were randomly divided into five groups: control group, model EA...

Group 2 innate lymphoid cells (ILC2s) represent a new effector leukocyte population that mediates type-2 immune response. However, the contribution of ILC2s to allergic rhinitis (AR) is currently not well defined.To evaluate potential existence and function allergen-induced in experimental AR.We established murine model AR using ovalbumin (OVA) aluminium hydroxide. The OVA-induced were sorted purified from mouse nasal-associated tissue (NALT). Then, we assessed responses recombinant...

Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD). This study aimed to investigate expression NGF, its high affinity receptor tropomyosin kinase A (TrkA) EGC activation marker fibrillary acidic protein (GFAP) in gastric mucosa patients FD association these proteins dyspeptic symptoms.Gastric mucosal biopsies taken from 27 (9 epigastric...

Desvenlafaxine succinate (DVS) is a novel serotonin and norepinephrine reuptake inhibitor. The aim of this study was to investigate the effects DVS on visceral hypersensitivity solid gastric emptying in rodent model hyperalgesia. Twenty-eight hyperalgesia rats 20 control were used. Visceral sensitivity during distention (GD) assessed by recording electromyogram (EMG) at pressures 20, 40, 60, 80 mmHg. with doses 1, 10, 30 mg/kg administrated gavage, 5-HT1A antagonist (WAY-100635, 0.3 mg/kg)...

MicroRNA-146a (miR-146a) plays a critical role in the regulation of autoinflammatory diseases, including gout. There is growing evidence that miR-146a gene single nucleotide polymorphisms (SNPs) are associated with different but no genetic relevance studies to gout have been reported by now.The purpose this study was examine relationship between rs57095329 polymorphism and susceptibility primary Chinese Han population.A case-control performed report potential association functional SNP...

To assess the diagnostic value of a combination continuous intragastric pH and bilirubin monitoring in detection duodenogastric reflux (DGR), effects diet on absorbance.30 healthy volunteers were divided into two groups: standard group (Group 1) 18 cases, free 2)12 cases. Each subjects subjected to simultaneous 24-hour spectrophotometric concentration (Bilitec 2000).There was no difference preprandial phase absorbance between groups. The postprandial significantly increased 2 than 1. There...

Cyclin D1 (CCND1) is a regulatory protein involved in the cell cycle of both normal and neoplastic cells. Polymorphism this gene at codon 242 exon 4 (A870G) has an impact on risk several human cancers. The purpose study was to relation between CCND1 A870G polymorphism non-cardiac gastric cancer Chinese population.The population consisted 159 patients with 162 cancer-free controls. 870A/G genotyped by polymerase chain reaction-restriction fragment length (PCR-RFLP) assay sequencing.CCND1...

Desvenlafaxine succinate (DVS; Pristiq) is a new antidepressant, serotonin-norepinephrine reuptake inhibitor. Antidepressants have been widely used for the treatment of functional gastrointestinal disorders. Possible roles DVS on motility not studied. The aim this study was to investigate effects gastric slow waves (GSW), antral contractions, and accommodation in dogs. Fifteen healthy dogs implanted with serosal electrodes cannula were studied four separate sessions: control, (50 mg),...

Studies have suggested that dietary copper and zinc intakes may be associated with irritable bowel syndrome (IBS), however, prospective evidence is lacking. This study aimed to prospectively investigate the relationship between copper, zinc, copper/zinc (Cu/Zn) ratio development of IBS in a long-term cohort. A total 175,421 participants UK Biobank without at baseline were included. Dietary intake was assessed by Oxford WebQ. New-onset identified using ICD-10 codes (K58). Cox proportional...

Abstract Background: Previous studies have suggested that exposure to air pollutants may be associated with specific blood indicators or anemia in certain populations. However, there is insufficient epidemiological data and prospective evidence evaluate the relationship between environmental pollution types of anemia. Methods: We conducted a large-scale cohort study based on UK Biobank. Annual average concentrations NO 2 , PM 2.5 2.5−10 10 were obtained from ESCAPE using Land Use Regression...

Allergic inflammation is exacerbated by allergen-induced

Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of allergic rhinitis (AR). This study aimed evaluate intervention Orai1 on response nuocytes from AR mice interleukin (IL)-33.We established a murine model AR. were obtained mouse nasal-associated lymphoid tissue. Then, we assessed expressions Orai1, Ca2+ mean fluorescence intensity (MFI) nuocytes, their cellular recombinant (rm) IL-33. After that, administered rmlentivirus vectors (lenti) that encoded small...