A5039371962- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Visual perception and processing mechanisms
- RNA and protein synthesis mechanisms
- Advanced Memory and Neural Computing
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
Allen Institute
2021-2024
Allen Institute for Neural Dynamics
2024
Salk Institute for Biological Studies
2019
University of California, San Diego
2019
University of Washington
2012
Abstract The claustrum is uniquely positioned to communicate with almost all higher-order cortical areas through widespread and reciprocal anatomical projections, yet the in vivo functional properties of neurons are not well understood. Here we use microendoscope imaging mice measure activity populations genetically-labelled Gnb4+ neurons. We find that only a small fraction cells anterior responsive visual or auditory stimuli when delivered under passive wakeful conditions. In contrast,...
SUMMARY The claustrum is a small subcortical structure with widespread connections disparate regions of the cortex. These far-reaching projections have led to many hypotheses concerning its function. However, we know little about how input affects neural activity in cortex, particularly beyond frontal areas. Here, using optogenetics and multi-regional Neuropixels recordings from over 15,000 neurons awake mice, demonstrate that effect differs depending on brain area, layer, cell type. Brief...
Abstract The relationships between protein synthesis and neuronal survival are poorly understood. In chicken nucleus magnocellularis (NM), significant alterations in overall precede death induced by deprivation of excitatory afferent activity. Previously we demonstrated an initial reduction the rate all deprived NM neurons, followed quick recovery (starting at 6 hours) some, but not all, neurons. Neurons with recovered ultimately survive, whereas others become “ghost” cells (no detectable...
Abstract To understand the neural basis of behavior, it is essential to measure spiking dynamics across many interacting brain regions. While new technologies, such as Neuropixels probes, facilitate multi-regional recordings, significant surgical and procedural hurdles remain for these experiments achieve their full potential. Here, we describe a novel 3D-printed cranial-replacement implant (SHIELD) enabling electrophysiological recordings from distributed areas mouse brain. This...