Tamina K. Ramirez
A5032043052- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Gene Regulatory Network Analysis
- CCD and CMOS Imaging Sensors
- Neural Networks and Applications
- Child Development and Digital Technology
- Electrochemical Analysis and Applications
Allen Institute
2019-2024
Allen Institute for Brain Science
2019-2021
Seattle Children's Hospital
2013
The visual cortex is hierarchically organized, yet the presence of extensive recurrent and parallel pathways make it challenging to decipher how signals flow between neuronal populations. Here, we tracked spiking activity recorded from six interconnected levels mouse hierarchy. By analyzing leading lagging spike-timing relationships among pairs simultaneously neurons, created a cellular-scale directed network graph. Using module-detection algorithm cluster neurons based on shared...
Abstract The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level interactions across multiple levels this hierarchy lacking, partially due challenge simultaneously recording activity numerous regions. Here, we describe a large, open dataset (part Allen Brain Observatory ) that surveys spiking units in six cortical two...
Extracellular electrophysiology and two-photon calcium imaging are widely used methods for measuring physiological activity with single-cell resolution across large populations of cortical neurons. While each these two modalities has distinct advantages disadvantages, neither provides complete, unbiased information about the underlying neural population. Here, we compare evoked responses in visual cortex recorded awake mice under highly standardized conditions using either genetically...
Abstract Extracellular electrophysiology and two-photon calcium imaging are widely used methods for measuring physiological activity with single-cell resolution across large populations of neurons in the brain. While these two modalities have distinct advantages disadvantages, neither provides complete, unbiased information about underlying neural population. Here, we compare evoked responses visual cortex recorded awake mice under highly standardized conditions using either or...
Abstract To understand the neural basis of behavior, it is essential to measure spiking dynamics across many interacting brain regions. While new technologies, such as Neuropixels probes, facilitate multi-regional recordings, significant surgical and procedural hurdles remain for these experiments achieve their full potential. Here, we describe a novel 3D-printed cranial-replacement implant (SHIELD) enabling electrophysiological recordings from distributed areas mouse brain. This...
Human infants are increasingly exposed to excessive fast‐paced television viewing leading sensory overstimulation, which may result in significant deficits cognition and attention. We tested this hypothesis a mouse model young mice (P10) were audio visual overstimulation for six hours per day total of 42 days. Overstimulation had detrimental effects resulting diminished cognition, hyperactivity increased risk taking (Christakis et al. 2012). Prior studies have shown that exposing an enriched...
Recent advances in neuroscientific experimental techniques have enabled us to simultaneously record the activity of thousands neurons across multiple brain regions. This has led a growing need for computational tools capable analyzing how task-relevant information is represented and communicated between several Partial decompositions (PIDs) emerged as one such tool, quantifying much unique, redundant synergistic two or more regions carry about message. However, computing PIDs computationally...
Abstract The visual cortex is organized hierarchically, but the presence of extensive recurrent and parallel pathways make it challenging to decipher how signals flow between neuronal populations. Here, we tracked spiking activity recorded from six interconnected levels mouse hierarchy. By analyzing leading lagging spike-timing relationships among pairs simultaneously neurons, created a cellular-scale directed network graph. Using module-detection algorithm cluster neurons based on shared...
The visual cortex is organized hierarchically, but the presence of extensive recurrent and parallel pathways make it challenging to decipher how signals flow between neuronal populations. Here, we tracked spiking activity recorded from six interconnected levels mouse hierarchy. By analyzing leading lagging spike-timing relationships among pairs simultaneously neurons, created a cellular-scale directed network graph. Using module-detection algorithm cluster neurons based on shared...