A5027461492- Telomeres, Telomerase, and Senescence
- Advanced Proteomics Techniques and Applications
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Bioinformatics and Genomic Networks
- RNA regulation and disease
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Machine Learning in Bioinformatics
- Metal complexes synthesis and properties
- Bacteriophages and microbial interactions
- Genetics, Bioinformatics, and Biomedical Research
- Ubiquitin and proteasome pathways
- AI in cancer detection
- Renal and related cancers
- Blood disorders and treatments
- Artificial Intelligence in Healthcare and Education
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
The University of Sydney
2011-2024
Children's Medical Research Institute
2020-2024
Westmead Institute
2022
Sun Yat-sen University
2015-2018
UNSW Sydney
2011
The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted identification new cancer biomarkers. Here, proteomes 949 cell lines across 28 tissue types are analyzed by mass spectrometry. Deploying a workflow to quantify 8,498 proteins, these data capture evidence cell-type post-transcriptional modifications. Integrating multi-omics, drug response, CRISPR-Cas9 gene essentiality screens with deep...
The telomerase is responsible for adding telomeric repeats to chromosomal ends and consists of the reverse transcriptase TERT RNA subunit TERC. expression activity are tightly regulated, aberrant activation has been observed in >85% human cancers. To better understand regulation, we performed immunoprecipitations coupled with mass spectrometry (IP-MS) identified cold inducible RNA-binding protein (CIRP or hnRNP A18) as a telomerase-interacting factor. We have found that CIRP necessary...
Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. The mutation of Shwachman-Bodian-Diamond (SBDS) gene has been proposed to be major causative reason for SDS. Although SBDS patients were reported have shorter telomere length in granulocytes, the underlying mechanism still unclear. Here we provide data elucidate role protection. We demonstrate that deficiency leads shortening. found overexpression...
Summary The proteome provides unique insights into biology and disease beyond the genome transcriptome. Lack of large proteomic datasets has restricted identification new cancer biomarkers. Here, proteomes 949 cell lines across 28 tissue types were analyzed by mass spectrometry. Deploying a clinically-relevant workflow to quantify 8,498 proteins, these data capture evidence type post-transcriptional modifications. Integrating multi-omics, drug response CRISPR-Cas9 gene essentiality screens...
Abstract Artificial intelligence applications in biomedicine face major challenges from data privacy requirements. To address this issue for clinically annotated tissue proteomic data, we developed a Federated Deep Learning (FDL) approach (ProCanFDL), training local models on simulated sites containing pan-cancer cohort (n=1,260) and 29 cohorts held behind private firewalls (n=6,265), representing 19,930 replicate data-independent acquisition mass spectrometry (DIA-MS) runs. Local parameter...