A5019251612- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Urological Disorders and Treatments
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Neurogenetic and Muscular Disorders Research
- Acute Kidney Injury Research
- Urinary Tract Infections Management
- Autopsy Techniques and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Magnesium in Health and Disease
- Bone and Joint Diseases
- Cardiac Arrest and Resuscitation
- Neonatal and fetal brain pathology
- interferon and immune responses
- CAR-T cell therapy research
Dokuz Eylül University
2019-2025
Denizli Devlet Hastanesi
2024-2025
Pediatrics and Genetics
2024
CARE USA
2020
ABSTRACT Background Two earthquakes on 6 February 2023 destroyed 10 cities in Türkiye. We report our experience with pediatric victims during these catastrophes, a focus crush syndrome related–acute kidney injury (Crush-AKI) and death. Method Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, overall outcomes were recorded. Results A total of 903 injured children (median age 11.62 years) evaluated. Mean TUR 13 h (interquartile...
Abstract Background As voiding cystourethrography is invasive and exposes to radiation urinary tract infection (UTI), identifying only high-grade reflux important. We aimed identify clinical, laboratory imaging variables associated with primary in children presenting UTIs and/or dilatation develop a prediction model for severe reflux. Methods Data of who underwent due UTI were retrospectively analyzed demographic, clinical findings. Patients (grades 4–5) compared the rest these parameters...
ABSTRACT Background Spinal muscular atrophy (SMA) is a motor neuron disease caused by mutations in the SMN1 gene. Nusinersen, an antisense oligonucleotide, has been shown to improve function SMA patients. However, concerns regarding its renal safety remain as previous studies have linked similar treatments toxicity. Objective The aim of this study was evaluate effects nusinersen treatment on platelet counts and functions, specifically urine protein excretion, patients estimate safe urinary...
Immune checkpoint inhibitors are humanized antibodies that inhibit downregulatory receptors on T cells, enhancing the antitumor activity of these cells. However, they have been associated with a wide range systemic immune-related adverse events, including renal toxicities, among others. Most events acute interstitial nephritis causing kidney injury. Recently, immune inhibitors-associated glomerular diseases, IgA nephropathy, reported in adults. adult cases involvement had also concomitant...
Nephrocalcinosis is associated with conditions that cause hypercalcemia and the increased urinary excretion of calcium, phosphate, and/or oxalate. A monogenic etiology found in almost 30% childhood-onset nephrocalcinosis which also a common manifestation primary hyperparathyroidism. We discuss child features mimicking hyperparathyroidism.A 7-year-old girl presented nephrocalcinosis. Hypercalciuria, hyperphosphaturia, mild hypercalcemia, hypophosphatemia elevated parathyroid hormone levels...
Objective: We aimed to evaluate MEFV mutation frequency and the effects of mutations on clinical course including renal involvement in children with Henoch-Schonlein Purpura (HSP).
 Methods: Children a diagnosis HSP who were evaluated for presence enrolled this study. Patients primarily assigned into two groups based as Group 1 patients without 2 at least one allele (heterozygous, homozygous, or compound heterozygous). also investigated specifically M694V by comparing not carrying...
<title>Abstract</title> Background As voiding cystourethrography is invasive and carries the risks of radiation urinary tract infection, identifying only high-grade reflux important. We aimed to identify risk factors for severe in children presenting with infections and/or dilatation develop a prediction model reflux. Methods Data who underwent due were retrospectively analyzed demographic, clinical imaging findings. Patients (grades 4–5) compared rest these parameters was developed Results...
To the Editors: Mycoplasma pneumoniae is known to cause a wide range of extrapulmonary diseases affecting multiple organs in human body, while rhinovirus infection similarly has potential serious complications both lungs and other body systems.1 We present 2 pediatric cases M. coinfection that led renal complications, highlighting importance recognizing atypical presentations viral respiratory infections. CASE 1 A 13-year-old male presented with 15-day history runny nose, cough, sputum...
Osteonecrosis (ON) is bone death caused by inadequate blood supply and its optimal management remains uncertain. We describe the outcomes of BP (pamidronate) treatment in our patients. Data regarding clinical, laboratory, magnetic resonance imaging (MRI) studies, mineral density measurements (BMD) were recorded before one year after (reevaluation). The severity clinical picture was assessed using criteria common terminology for adverse events (CTCAE). There four female patients (patient 1,...
Objectives: We have no series report concerning genetic etiology of Alport Syndrome AS in our country. So, we aimed to investigate related pathogenic variants COL4A3, COL4A4 and COL4A5 genes index cases their families who referred center.Patients Methods: The study includes 32 subjects 17 relatives are investigated between years 2018-2019 by NGS targeting the coding regions genes. test results clinical findings studied retrospectively.Results: By presented study, 19 individuals identified...
Objective: Acute kidney injury (AKI) is still an important cause of morbidity and mortality in the neonatal period, despite recent improvements on perinatal care. In this study, frequency, etiological causes, clinical characteristics, newborns with AKI a tertiary intensive unit (NICU) were investigated. Methods: Medical records admitted between 2007 2011 evaluated patients who developed first 28 days life determined. Clinical primary cause, mortality, highest creatinine recorded. Results: It...