A5008664427- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Pituitary Gland Disorders and Treatments
- Nuclear Structure and Function
- Hormonal and reproductive studies
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- RNA Research and Splicing
- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Thyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Immunodeficiency and Autoimmune Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Ovarian function and disorders
- Diet and metabolism studies
- Bone and Joint Diseases
- Drug-Induced Adverse Reactions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac tumors and thrombi
- PARP inhibition in cancer therapy
- Heparin-Induced Thrombocytopenia and Thrombosis
- RNA regulation and disease
- Mast cells and histamine
- Adipokines, Inflammation, and Metabolic Diseases
Dokuz Eylül University
2021-2024
University of Michigan
2023-2024
Owl Research Institute
2022
ENT and Allergy
2021
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2020
Creative Commons
2020
Early puberty is development of secondary sex characteristics earlier than the expected normal age range. We subjectively observed an increased frequency early during Coronavirus disease-2019 (COVID-19) lockdown and aimed to show clinical, demographic cases change in its incidence.Female patients with central precocious (CPP, n=28) rapidly progressive (RPEP, n=61), presenting our clinic before (January 2019-March 2020) COVID-19 pandemic (April 2020-June 2021) were included.Among 28 CPP...
Abstract Purpose We aimed to determine the frequency of transient congenital hypothyroidism (TCH) in 17 participating centers Türkiye, evaluate etiological distribution permanent (PCH) cases, and investigate role laboratory clinical findings predicting TCH. Methods This retrospective observational multicenter study included patients from pediatric endocrinology identified by “National Newborn Screening Program” (NNSP) who were born 2015 followed for 6 years. Demographic, clinical,...
Craniopharyngiomas (CPG) have complex treatment challenges due to their proximity vital structures, surgical and radiotherapeutic complexities, the tendency for recurrence. The aim of this study was identify prevalence endocrine metabolic comorbidities observed during initial diagnosis long-term follow-up in a nationwide cohort pediatric CPG patients. A further highlight difficulties associated with management.
Established reference values are critical for the interpretation of immunologic assessments. In particular, proportion and absolute counts T- B- cell subpopulations subject to change with age ethnicity. We aimed establish age- specific lymphocyte subsets using updated immunophenotyping panels.We studied a total 297 healthy Turkish subjects aged 0 50 years, stratified into major brackets in cluster factor 10 per age-group. The predetermined intervals contained randomly allocated participants...
This study aimed to determine the prevalence and predictors of euthyroid sick syndrome (ESS) in pediatric intensive care, establish a link between thyroid function tests mortality.Between January 2015 March 2020, children admitted our care unit (PICU) tested for free triiodothyronine (fT3), thyroxine (fT4), thyrotropin (TSH) levels were included. Patients with decreased fT3, normal or fT4, TSH assigned ESS group. The association biochemical indicators ESS, as well relationship fT3 mortality,...
Large cell calcifying Sertoli tumours (LCCSCTs) are one of the infrequent causes prepubertal gynaecomastia. Most these in content Peutz-Jeghers syndrome (PJS) or other familial syndromes (Carney complex).Here, we report a long-term follow-up an 8.5-year-old boy with diagnosis PJS, who presented bilateral gynaecomastia, advanced bone age and accelerated growth velocity, were found to have multifocal testicular microcalcifications. As findings compatible LCCSCT, anastrozole was initiated....
The exact mechanism of partial clinical remission in type 1 diabetes mellitus (T1DM) has not been elucidated yet. severity the inflammation at time diagnosis may affect occurrence or duration this phase. We aimed to investigate relationship between hematological inflammatory parameters T1DM and (i) daily insulin requirement during follow-up (ii) presence period, which was determined according dose-adjusted HbA1c levels.A single-center retrospective study conducted, including children who...
Abstract Disclosure: D. Gilio: None. M.C. Foss de Freitas: Advisory Board Member; Self; PTC Therapeutics. Speaker; Amryt. O. Besci: M. Celik Guler: A. Neidert: I. Yildirim: B. Akinci: Consulting Fee; Regeneron Pharmaceuticals, Alnylam Amryt, AstraZeneca, Boehringer Ingelheim, Lilly, MSD, Novartis Novo Nordisk, Sanofi-Aventis, Servier, Third Rock Ventures. E.A. Oral: Pharmaceuticals. Grant Recipient; Research Investigator; Fractyl, Ionis Pharmaceuticals Inc., GI Dynamics, Rhythm Other;...
Osteonecrosis (ON) is bone death caused by inadequate blood supply and its optimal management remains uncertain. We describe the outcomes of BP (pamidronate) treatment in our patients. Data regarding clinical, laboratory, magnetic resonance imaging (MRI) studies, mineral density measurements (BMD) were recorded before one year after (reevaluation). The severity clinical picture was assessed using criteria common terminology for adverse events (CTCAE). There four female patients (patient 1,...
Both body weight (BW)- and surface area (BSA)-based dosing regimens have been recommended for growth hormone (rhGH) replacement. The aim was to compare the two determine if either resulted in inadequate treatment depending on anthropometric factors.The retrospective study included children diagnosed with idiopathic isolated deficiency. BW-based mcg/kg/day converted BSA mg/m2/day equivalent amounts of given rhGH. Those a BW-to-BSA ratio more than 1 were allocated “relatively over-dosed...
The aim was to evaluate the adverse events seen after Coronavirus disease-2019 (COVID-19) vaccination in pediatric patients with diagnosed endocrinological problems and compare them healthy controls.
There is no strong evidence that any specific diet the preferred treatment for lipodystrophy syndromes. Here we remark on benefits of a very-low-calorie (VLCD) in patient with familial partial type 2 (FPLD2). A 38-year-old female diagnosed FPLD2, history multiple comorbidities, underwent 16 weeks VLCD short-term goal improving her metabolic state rapidly to achieve pregnancy by vitro fertilization (IVF). We observed reduction 12.3 kg body weight and 1.4% hemoglobin A1c. The decrease area...
Since there is no gold standard laboratory variable for adjustment of treatment in congenital adrenal hyperplasia (CAH), the aim was to assess use a 4-hour profile serum 17-hydroxyprogesterone (17-OHP) determine most appropriate sample time and level 17-OHP predicting metabolic control evaluate role sex hormone-binding globulin (SHBG) hyperandrogenemia.This study included children with salt-wasting CAH. Measurements cortisol were made from samples obtained before 1, 2, 4 hours after morning...
Brief summary: This paper describes 18 patients with bi-allelic leptin deficiency (LEP, n=11) or receptor (LEPR, n=7), including 10 new cases and two novel variants. In addition, in a review of the literature (until July 2022), authors identified n=75 living LEP n=90 LEPR (n=152 included for comparison between groups).
We aimed to describe the clinical characteristics of patients with congenital combined pituitary hormone deficiency (CPHD) and evaluate first-year growth responses individuals CPHD isolated (IGHD) in order establish influence other deficiencies on response.This retrospective study was conducted four tertiary care centers Turkey. The records diagnosed (n=39) severe IGHD (n=50) were collected. Cases acquired lesions or chronic diseases not included study. Data are presented as median...
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare genetic mainly associated with Carney complex (CNC), which caused by germline mutations of the regulatory subunit type 1A (RIα) cAMP-dependent protein kinase (PRKAR1A) gene. We report three cases suffering from CNC unique features in diagnosis and follow-up. All had obesity cushingoid appearance exhibited laboratory characteristics hypercortisolism. However biochemical radiological examinations initially suggested Cushing's...