A5112005342- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Effects of Radiation Exposure
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Radiation Therapy and Dosimetry
- Parasitic Diseases Research and Treatment
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Polyomavirus and related diseases
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrest and Resuscitation
- Tea Polyphenols and Effects
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 detection and testing
- Rural Development and Agriculture
- Educational and Organizational Development
- Colorectal Cancer Surgical Treatments
- Air Quality and Health Impacts
- Viral-associated cancers and disorders
- Metabolomics and Mass Spectrometry Studies
Georgia Institute of Technology
2025
Women's Resource Center
2025
Hospital General Universitario De Valencia
2021
Universidad de Salamanca
2001-2020
Hoag Memorial Hospital Presbyterian
2020
Uniformed Services University of the Health Sciences
2016-2018
Baylor University Medical Center
2010-2016
University of San Francisco
2015
Baylor Scott & White Health
2010-2012
University of Bologna
2010-2011
Abstract Introduction More than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics first 12 U.S. patients with COVID-19. Methods collected demographic, exposure, information from confirmed by CDC during January 20–February 5, 2020 to Respiratory, stool, serum, urine specimens were submitted for SARS-CoV-2 rRT-PCR testing, virus culture, whole genome sequencing. Results Among patients,...
Abstract Purpose: Although cyclooxygenase (COX)-2 inhibitors could represent the most effective chemopreventive tool against colorectal cancer (CRC), their use in clinical practice is hampered by cardiovascular side effects. Consumption of ω-3-polyunsaturated fatty acids (ω-3-PUFAs) associated with a reduced risk CRC. Therefore, this study, we assessed efficacy novel 99% pure preparation ω-3-PUFA eicosapentaenoic acid as free (EPA-FFA) on polyps ApcMin/+ mice. Experimental design: and...
The COVID-19 pandemic disrupted the living arrangements of many college students in United States, potentially impacting their academic development, which plays a critical role mental health. At start pandemic, university closures led to an abrupt transition from face-to-face instruction online instruction, may have caused significant challenges for students, particularly lesbian, gay, bisexual, transgender, queer, and others who identify as having minority sexual orientation and/or gender...
Giulia Piazzi 1,2,3 , Lucia Fini 3,4 Michael Selgrad 3,5 Melissa Garcia 3 Yahya Daoud 6 Thomas Wex 5 Peter Malfertheiner Antonio Gasbarrini 7 Marco Romano 8 Richard L. Meyer 9 Robert M. Genta 10 James G. Fox 11 C. Boland Franco Bazzoli 1 and Luigi Ricciardiello Department of Clinical Medicine, University Bologna, Italy 2 Center for Applied Biomedical Research (CRBA), S.Orsola-Malpighi Hospital, Internal Baylor Institute Sammons Cancer Center, Medical Dallas, United States 4 Gastroenterology,...
Abstract The Western diet (WD) is associated with a higher incidence of colorectal cancer (CRC) than the Mediterranean diet. Polyphenols extracted from Annurca apple showed chemopreventive properties in CRC cells. A multifactorial, four-arm study by using wild-type (wt) and ApcMin/+ mice was carried out to evaluate effect on polyp number growth APE treatment (60 μmol/L) ad libitum drinking water combined WD or balanced (BD) for 12 weeks. Compared treatment, we found significant drop body...
Exposure to ionizing radiation induces a cascade of molecular events that ultimately impact endogenous metabolism. Qualitative and quantitative characterization metabolomic profiles is pragmatic approach studying the risks exposure since it provides phenotypic readout. Studies were conducted in irradiated nonhuman primates (NHP) investigate metabolic changes plasma plasma-derived exosomes. Specifically, rhesus macaques (Macaca mulatta) exposed cobalt-60 gamma-radiation samples collected...
Threats of nuclear terrorism coupled with potential unintentional ionizing radiation exposures have necessitated the need for large-scale response efforts such events, including high-throughput biodosimetry medical triage. Global metabolomics utilizing mass spectrometry (MS) platforms has proven an ideal tool generating large compound databases relative quantification and structural information in a short amount time. Determining metabolite panels requires experimentation to evaluate many...
Aberrant activation of the canonical WNT signaling is a feature colorectal cancer (CRC). Van-Gogh-like 2 (VANGL2) belongs to non-canonical pathway whose inhibits signaling. In this study, we investigated role VANGL2 and its epigenetic regulation in CRC. expression promoter methylation after 5-aza-2′-deoxycytidine (5-aza) treatment were evaluated CRC cells. DNA samples from 418 sporadic CRCs tested for microsatellite instability (MSI). Proliferation, colony formation cells overexpression....
The availability of safe and effective radiation countermeasures for the military civilian population represents a significant unmet medical need. To expedite development life-threating situations, United States Food Drug Administration (US FDA) has implemented "Animal Rule" which applies to evaluation drugs biologics reduce or prevent life-threatening conditions caused by exposure lethal permanently disabling agents where human efficacy trials are neither feasible nor ethical. In addition,...
JC virus (JCV) is a polyomavirus that infects approximately 75% of the population and encodes T antigen (T-Ag) gene, which oncogenic inactivates p53 pRb/p107/p130 protein families. Previous work in our lab has identified presence T-Ag colorectal neoplasms. While JCV remains latent state for majority those infected, we hypothesized disturbance immunological control may permit to reactivate, be involved development neoplasia. Our aim was determine cell mediated immune response T-Ag, if it...
The possible detonation of a radiological dispersal device or improvised nuclear in metropolitan city, the accidental exposures to radiation source, accidents, all-to-often threats radiological/nuclear terrorism have led urgent need develop essential analytic tools assess such exposures, especially doses exposed individuals. This exposure-assessing work using biological samples, and discipline, is known as biodosimetry. As late, this field has progressed significantly it made use advances...
Verger, Judy; Kubis, Sherri; Perkel, Madeline; Waxler, Megan; Garcia, Melissa; Meyers, Robin; Fry, Michael; Srinivasan, Vijay