Using a conditional life or death screen in yeast, we have isolated tomato (Lycopersicon esculentum) gene encoding phospholipid hydroperoxide glutathione peroxidase (LePHGPx). The protein displayed reduced glutathione-dependent activity, but differs from counterpart mammalian enzymes that instead contain an active seleno-Cys. LePHGPx functioned as cytoprotector yeast (Saccharomyces cerevisiae), preventing Bax, hydrogen peroxide, and heat stress induced cell death, while also delaying...

Genetic studies in mice and zebrafish have revealed conserved requirements for Endothelin 1 (Edn1) signaling craniofacial development. Edn1 acts through its cognate type-A receptor (Ednra) to promote ventral skeletal fates lower-jaw formation. Here, we describe the isolation characterization of two ednra genes - ednra1 ednra2 both which are expressed progenitors embryonic neural crest. We show that they play partially redundant roles formation development jaw joint. Knockdown Ednra1 leads...

This paper presents a progressive match filling (PMF) technique to reduce the peak current and power dissipation during fast capture cycle in broadside delay fault testing. The proposed method fills unspecified values (X) generated initialization vector such that resulting launch at minimal Hamming distance from vector. does not require any hardware modification can be used obtain test sets two pattern tests. Experimental results show reduces by 40.59% on average up 54.17% for large ISC AS...

It is not well understood how paracrine communication between basal and luminal cell populations in the mammary gland affects tumorigenesis. During ErbB2-induced tumorigenesis, enriched stem cells that represent a subpopulation of exhibit enhanced tumorigenic capacity compared with corresponding progenitors. Transcript profiling tumors derived from tumor-initiating (TIC) revealed preferential loss noncanonical Wnt ligand WNT5A TIC-derived tumors. Heterozygous was correlated shorter survival...

Gene duplication has been proposed to drive the evolution of novel morphologies. After gene duplication, it is unclear whether changes in resulting paralogs' coding-regions, or their cis-regulatory elements, contribute most significantly assembly regulatory networks. The Transcription Factor Activator Protein 2 (Tfap2) was duplicated chordate lineage and essential for development neural crest, a tissue that emerged with vertebrates. Using tfap2-depleted zebrafish background, we test ability...

A model of the gene-regulatory-network (GRN), governing growth, survival, and differentiation melanocytes, has emerged from studies mouse coat color mutants melanoma cell lines. In this model, Transcription Factor Activator Protein 2 alpha (TFAP2A) contributes to melanocyte development by activating expression gene encoding receptor tyrosine kinase Kit. Next, ligand-bound Kit stimulates a pathway transcription factor Microphthalmia (Mitf), which promotes survival melanocytes Tyrosinase...

This paper presents a method of generating tests for transition faults using stuck-at such that the peak power is minimum possible given set faults. The proposed suitable use in testing scan designs employ enhanced scan. reduces consumption benchmark circuits by 19% on average with essentially same test size and fault coverage compared to an earlier method.

We analyze the implications of tournament-like competition in mutual fund industry for shareholder welfare using a framework that addresses both (a) risk taking incentives, and (b) effort incentives facing managers. compare ex ante utility under two competing regimes: tournament regime characterized by future flows accruing to winner fund, no-tournament which are not sensitive past performance. Our analysis suggests tournaments can be beneficial when informational costs cash flow sensitivity...

In Drosophila melanogaster, the anteroposterior (AP) and dorsoventral (DV) axes of oocyte future embryo are established through localization translational regulation gurken (grk) mRNA. This process involves binding specific factors to RNA during transport a dynamic remodeling grk-containing ribonucleoprotein (RNP) complexes once they have reached their destination within oocyte. ovaries spindle-class females, an activated DNA damage checkpoint causes inefficient Grk translation...

This paper presents a new technique to improve the delay fault coverage by re-ordering flip-flops in scan chain. Unlike prior techniques where can be reordered arbitrarily form chain order, we restrict distance which flip-flop moved create order. The restriction makes it practical make post-synthesis, local layout modifications accommodate It also minimizes routing overhead required for Given post-synthesis re-order minimize number of undetectable faults due test pattern dependency. Although...

Abstract The purpose of this research is to determine the role inflammasome-mediated production interleukin(IL)-1β in obesity-associated breast cancer progression. Previous studies have shown that obesity a risk factor for both developing and Obesity also associated with development invasive ductal carcinoma (IDC) versus in-situ (DCIS; non-invasive). A number hypotheses been proposed explain association between It has hypothesized chronic inflammation adipose tissue obesity, especially...

In this paper, we examine jointly a young and innovative firm’s problem of managing its talent decision to exit the capital market. We look at choice from both ex post perspective ante perspective. From perspective, going forwards as standalone entity with publically traded stock (i.e. an IPO exit) allows firm compensate motivate worker in most efficient way. it is more cost for hire growth potential than mature skillful worker, reinforces dependence on stock-based compensation inclination...

Recently, Markov sources were shown to achieve 100% fault efficiency at low area overhead when used as pseudo-random pattern generators in scan BIST. In this paper we give a new method of designing sources. The design attempts match probabilities 1 0 and transitions consecutive bits set test vectors, taking into account that the transition may be different for bit positions. Experimental results show proposed considerably reduces hardware lengths required coverage.

The 1970 amendment to the Investment Company Act of 1940 prohibited use option-like "bonus" performance incentive fees in mutual funds. Does this regulatory restriction serve investors interests? Despite obvious significance issue and despite long-standing interest it, answers provided literature are inconclusive at best. In research we propose address three questions that have a bearing on issue: (a) an fee provide appropriate incentives for portfolio manager?, (b) If is be used motivate...

Recently, Markov sources were shown to be effective in designing pseudo-random test pattern generators with low area overhead for built-in self-test of scan designs. This paper presents a new generation scheme based on source and partial bit-fixing technique. A method is proposed the computation state transition probabilities statistics deterministic set. enhanced by logic, which fixes group consecutive inputs all-0 or all-1. Experimental results show that BIST can achieve 100% fault...