The oral administration of Mentha extract (ME) before exposure to gamma radiation was found be effective in increasing the frequency radiation-induced endogenous spleen colonies. A significant increase weight observed animals and combined group comparison irradiation-alone on day 10 postirradiation. Furthermore, a body all doses studied. regression analysis survival data yielded LD50/30 as 6.48 +/- 0.07 11.59 0.21 Gy for group, respectively, produced dose reduction factor (DRF) 1.78....

The radioprotective efficacy of aqueous extract Rajgira (Amaranthus paniculatus) leaves against whole body gamma radiation was studied in Swiss albino mice. oral administration at 800 mg/kg weight/day for 15 consecutive days before exposure to found be effective with the LD50/30 values 6.33 and 8.62 Gy irradiation alone Rajgira+irradiation group, respectively, giving a dose reduction factor 1.36. This effect accompanied increased endogenous spleen colonies weight without any side or...

The Panax ginseng has been used as traditional medicine for past several years among oriental people. present investigation made to assess the radioprotective efficacy of root extract in testicular enzymes Swiss albino mice. mice were divided into different groups. (i) Ginseng treated group: animals administered 10 mg/kg body weight i.p. (ii) Radiation exposed 8 Gy gamma radiation at dose rate 1.69 Gy/min distance 80 cm. (iii) Combination Animals continuously 4 d and on 4th day they...

The protective effect of Spirulina fusiformis extract against mercury toxicity studied in Swiss albino mice. Animals treated with HgCl2 (5.0 mg/kg b.wt. i.p.) showed a significant elevation lipid peroxidation level (LPO), aspartate amino transferase (AST) and alanine (ALT) activity. However, marked decline serum alkaline phosphatase activity reduced glutathione (GSH) content was recorded. Whereas, animals (800 orally) before after intoxication decrease LPO level, AST ALT increase GSH...

Investigation of Atwood number impact is crucial for comprehending the flow dynamics evolving hydrodynamic instability. In this paper, impacts on shock-driven instability at a backward-facing pentagonal interface in its early stages are explored numerically. The has unique property which incident angle shock wave constant along edge. This provides ideal environment shock-refraction process. To examine impact, we consider five distinct gases, including sulfur hexafluoride, krypton, argon,...

The chemopreventive and antimutagenic effects of an aqueous extract Mentha piperita leaves were evaluated by using 9 week medium term model benzo[a]pyrene (BP)-induced lung tumors. Lung tumors induced a single subcutaneous injection in the scapular region with BP newborn Swiss albino mice (<24 h old). oral administration (ME) showed significant reduction number from incidence 67.92% animals given only to 26.31%. inhibition rate was 61.26% ME treated group respect reference (BP-alone)....

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, referred to as "statins" have been extensively reported possess lipid lowering effects by inhibiting the synthesis of cholesterol liver and thereby increasing hepatic uptake reducing circulating levels. Growing body evidences shown that apart from effects, statins various pleiotropic include improvement in endothelial dysfunction, increased expression nitric oxide synthase (eNOS), enhanced bioavailability (NO), potent...

We report the chemopreventive property of an ethanollc extract leaves Ocimum sanctum (a traditional medicinal plant) on 7,12-dlmethylbenz[a]anthracene Induced skin papillomagenesis In male Swiss albino mice. A significant reduction values tumor Incidence, average number tumors per bearing mice and cumulative paplllomas was observed treated topically with leaf O. at either perMnltlatlonal, post-lnltlatlonal stages or continuously perl- as compared to corresponding control group. Topical...

Abstract In the present investigation chemopreventive action and antimutagenic effects of a standardized Panax Ginseng extract (EFLA400, processed ginseng containing high titre ginsenoside Rg3 (&gt;3.0% w[sol ]w) known as Phoenix ) in Swiss albino mice have been evaluated. The oral administration EFLA400 at 1, 3 10 mg[sol ]kg body weight pre, peri post‐initiational phases, showed significant reductions number, size papillomas. A reduction tumour incidence (71.41 ± 6.73%, 72.19 4.54% 70.46...

Cancer is not a single disease but group of complex genetic diseases aged cells. Chemoprevention cancer the attempt to use natural and synthetic compounds intervene in early stages cancer, before invasive begins. Consuming diet rich plant foods can provide milieu phytochemicals non-nutritive substances that possess health-protective effects. Some derived spices herbs as well other plants substantial preventive properties. Thus chemo potential naturally occurring great interest because their...

The modulatory potential of Spirulina fusiformis was observed on the hepatic and extrahepatic carcinogen metabolizing enzymes in Swiss albino mice at a dose 800 mg/kg b.w. given orally. A significant reduction cytochrome P450 content group treated with comparison control group. glutathione S-transferase activity induced significantly by treatment. There no change after animals were fed Spirulina. Copyright © 1999 John Wiley & Sons, Ltd.

The radioprotective effects of Mentha oil (Mentha piperita Linn.) against radiation induced haematological alterations in peripheral blood and the survival Swiss albino mice were studied. 40 micro L/animal/day for 3 consecutive days when fed orally prior to whole-body gamma irradiation (8 Gy) showed protection animals terms percentage parameters mice. Fifty per cent died within 20 100% mortality was observed up 30 post-irradiation control irradiated group. Whereas only 17% experimental group...

Extract of Adhatoda vasica (L) Nees leaves has been used for treatment various diseases and disorders in Ayurved Unani medicine. Modulatory effect ethanolic extract A. against radiation-induced changes terms histological alterations testis, reduced glutathione (GSH), lipid peroxidation (LPO), acid alkaline phosphatases levels, chromosomal Swiss albino mice was studied at post-irradiation intervals between 1 30 days. Mice exposed to 8 Gy radiation showed sickness including marked histology...

Radiomodifying effects of the root extract Panax ginseng were observed on testes Swiss albino mice at 10 and 20 mg/kg dose. The was found to be non-toxic when injected up 1200 mg/kg. A significant enhancement in survival time irradiated group compared with control pretreated extract. Besides time, radiation induced damage germ cells loss body weight also reduced markedly by this treatment. probable reason for radioprotection can correlated increased level liver glutathione (GSH). © 1998 John...

The modulatory effects of lead toxicity by Spirulina fusiformis (Oscillatoreaceae) were observed on the testes Swiss albino mice at a dose 800 mg/kg body weight. was non-toxic given. A significant enhancement in survival time pre- and post-treated group compared with control (lead treated) group. Lead induced also reduced terms weight, animal tubular diameter pre treated may be attributed to presence antioxidants, beta-carotene SOD enzyme.