A5038602347- Economic and Financial Impacts of Cancer
- Clinical practice guidelines implementation
- Platelet Disorders and Treatments
- Heart Failure Treatment and Management
- Lung Cancer Research Studies
- Signaling Pathways in Disease
- Viral gastroenteritis research and epidemiology
- Acute Kidney Injury Research
- Clostridium difficile and Clostridium perfringens research
- Health Systems, Economic Evaluations, Quality of Life
- Neuroendocrine Tumor Research Advances
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Microscopic Colitis
- Neuroblastoma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- Genital Health and Disease
- Neutropenia and Cancer Infections
- Cardiac Arrest and Resuscitation
- Blood groups and transfusion
- Mechanical Circulatory Support Devices
Flatiron Health (United States)
2022-2023
Yale University
2022
VA Tennessee Valley Healthcare System
2018
Vanderbilt University
2017-2018
Dana-Farber Cancer Institute
2016-2017
New York Hospital Queens
2014
Columbia University Irving Medical Center
2014
NewYork–Presbyterian Hospital
2014
Somatostatin receptor 2 (SSTR2) is overexpressed in a majority of neuroendocrine neoplasms, including small-cell lung carcinomas (SCLCs). SSTR2 was previously considered an inhibitory on cell growth, but its agonists had poor clinical responses multiple trials. The role this as potential therapeutic target cancer merits further investigation. We evaluated the expression cohort 96 primary tumors from patients with SCLC and found 48% expressed SSTR2. Correlation analysis both CCLE RNAseq...
Tail-anchored (TA) proteins contain a single C-terminal transmembrane domain (TMD) that is captured by the cytosolic Get3 in yeast (TRC40 humans). delivers TA to Get1/2 complex for insertion into endoplasmic reticulum (ER) membrane. How mediates of TMDs membrane poorly understood. Using bulk fluorescence and microfluidics assays, we show forms an aqueous channel reconstituted bilayers. We estimate diameter be ∼2.5 nm wide, corresponding circumference two complexes. find binding can seal...
381 Background: With the growing complexity and cost of cancer care, adoption oncology pathway tools as clinical decision support (CDS) has increased at point care. These have been shown to improve care quality, reduce variations in healthcare costs. Flatiron Assist (FA) is a customizable CDS tool that embedded electronic health record (EHR) facilitate selection documentation National Comprehensive Cancer Network (NCCN) guideline concordant treatment regimens. The time burden engaging with...
1578 Background: Clinical pathways have emerged as a strategy to provide value-based care by reducing treatment variation across oncology practice. Despite evidence for cost reduction and improved patient outcomes, adoption of clinical has met resistance in the community given concerns regarding impact on workflow, cost. Flatiron Assist, an EMR based tool, is promising solution minimizing workflow friction proving novel, streamlined user interface. Methods: The Abramson Cancer Center at...
Background: Patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) often require vasoactive medications to maintain organ perfusion. However, there are limited data on the real-world use of in this population. Methods: We used Vizient® Clinical Data Base identify patients aged ≥18 years who were admitted between 2015-2019 AMI-CS and required mechanical ventilation. report proportion receiving day as well site-level variability for medication strategies using...