A5064337787- Photosynthetic Processes and Mechanisms
- Biocrusts and Microbial Ecology
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Microbial Community Ecology and Physiology
- Cardiac electrophysiology and arrhythmias
- dental development and anomalies
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Protein Kinase Regulation and GTPase Signaling
- Barrier Structure and Function Studies
- Algal biology and biofuel production
- Nerve injury and regeneration
- Acute Kidney Injury Research
- Circadian rhythm and melatonin
- Dental Implant Techniques and Outcomes
- Obstructive Sleep Apnea Research
- Dietary Effects on Health
- Plant pathogens and resistance mechanisms
- Animal Nutrition and Physiology
- Heart Failure Treatment and Management
- Pancreatic function and diabetes
- Periodontal Regeneration and Treatments
- TGF-β signaling in diseases
Institute of Hydrobiology
2023
Chinese Academy of Sciences
2023
Laboratoire de Chimie Bactérienne
2020-2022
Sichuan Agricultural University
2019-2021
Ministry of Education of the People's Republic of China
2019-2021
Ministry of Agriculture and Rural Affairs
2019-2021
Guangdong Academy of Agricultural Sciences
2021
Centre National de la Recherche Scientifique
2020
Jinzhou Medical University
2019
CNR de la Résistance aux Antibiotiques
2019
The purpose of this study was to develop a model for assessing the 5-year risk developing type 2 diabetes from panel 64 circulating candidate biomarkers.Subjects were selected Inter99 cohort, longitudinal population-based approximately 6,600 Danes in nested case-control design with primary outcome conversion diabetes. Nondiabetic subjects, aged >or=39 years, BMI >or=25 kg/m(2) at baseline selected. Baseline fasting serum samples 160 individuals who developed and 472 did not tested. An...
Alterations in cardiac G protein-mediated signaling, most prominently G(q/11) are centrally involved hypertrophy and heart failure development. Several RGS proteins that can act as negative regulators of protein signaling expressed the heart, but their functional roles still poorly understood. expression changes have been described hypertrophic failing hearts. In this study, we report a marked decrease RGS2 (but not other major (RGS3-RGS5)) occurs prior to development different models with...
The semaphorin family contains a large number of secreted and transmembrane proteins, some which are known to act as repulsive axon guidance cues during development or be involved in immune function. We report here on the identification K1 (sema K1), first associated with cell surfaces via glycosylphosphatidylinositol linkage. Sema is highly homologous viral can interact specific cells, suggesting that like its counterpart, sema could play an important role regulating does not bind...
Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule. It also critical player in the regulation of cell size and behaviors such as aggregation phototaxis cyanobacteria, which constitute an important group prokaryotes for their roles ecology evolution Earth. However, c-di-GMP receptors have never been revealed cyanobacteria. Here, we report identification receptor, CdgR, from filamentous cyanobacterium Anabaena PCC 7120. Crystal structural analysis genetic studies demonstrate...
Aging people's bone regeneration potential is always impaired. Bone marrow stromal cells (MSCs) contain progenitors of osteoblasts. Donor age may affect MSCs' proliferation and differentiation potential, but the genomic base still unknown. Due to recent research's indication that a core circadian component, brain muscle ARNT-like 1 protein (BMAL1), has role in premature aging, we investigated normal aging mechanism mice with their MSCs Bmal1 gene/protein level.1, 6 16 month old C57BL/6 were...
This study aimed to investigate the effect of putrescine on immune function and intestinal bacteria weaning piglets. Twenty-four male castrated piglets their 21st day were randomly assigned into four groups: control (basal diet) treatment groups given basal diets supplemented with 0.05%, 0.1%, 0.15% for 11 days. Results as follows: (1) Dietary increased villus height, width, height/crypt depth surface area, decreased diarrhea index (P < 0.05). (2) lysozyme acid phosphatase activities amount...
Biomarkers for estimating reduced glucose tolerance, insulin sensitivity, or impaired secretion would be clinically useful, since these physiologic measures are important in the pathogenesis of type 2 diabetes mellitus.We conducted a cross-sectional study which 94 individuals, whom 84 had 1 more risk factors and 10 no known diabetes, underwent oral tolerance testing. We measured 34 protein biomarkers associated with 250-μL fasting serum samples. applied multiple regression selection...
Hanks-type kinases encoding genes are present in most cyanobacterial genomes. Despite their widespread pattern of conservation, little is known so far about role because substrates and the conditions triggering activation poorly known. Here we report that under diazotrophic conditions, normal heterocyst differentiation growth filamentous cyanobacterium Nostoc PCC 7120 require presence Pkn22 kinase, which induced combined nitrogen starvation conditions. By analyzing phenotype pkn22 mutant...
Local activation and long-range inhibition are mechanisms conserved in self-organizing systems leading to biological patterns. A number of them involve the production by developing cell an inhibitory morphogen, but how this becomes immune self-inhibition is rather unknown. Under combined nitrogen starvation, multicellular cyanobacterium Nostoc PCC 7120 develops nitrogen-fixing heterocysts with a pattern one heterocyst every 10–12 vegetative cells. Cell differentiation regulated HetR which...
In contrast to the other heterotrimeric GTP-binding proteins (G proteins) G s and i , functional role of o is still poorly defined. To investigate Gα in heart, we generated transgenic mice with cardiac-specific expression a constitutively active form o1 * (Gα *), predominant isoform heart. was increased 3- 15-fold from 5 independent lines, all which had normal life span no gross cardiac morphological abnormalities. We demonstrate enhanced contractile function vivo, along L-type Ca 2+ channel...
This investigation characterizes an acyltransferase enzyme responsible for the pathogenicity of Phytophthora melonis. The protein was characterized in vitro its physicochemical properties. biochemical characterization, including thermal and pH stability, revealed 35 °C temperature 7.0 as optimum conditions enzyme. Applying Tween-80 solution enhanced activity up to 124.9%. Comprehensive structural annotation two domains, A (ranging from residues 260 620) B 141 219). Domain had...
Weaning stress can cause metabolic disorders, gastrointestinal dysfunction, physical barrier injury and disease susceptibility, thus leading to impaired growth health of animals. Putrescine has the potential reduce effects. However, role putrescine supplementation on function antioxidant capacity in animals' organs is largely unknown. This study evaluates effects function, status related signalling molecule levels weaning piglets' organs. A total 24 piglets were assigned four treatment...
Whether spermine promotes the repair of porcine intestinal epithelium damage through Ras-related C3 botulinum toxin substrate 1 (Rac1)/phospholipase C-γ1 (PLC-γ1) signaling remains unclear. The current study investigated effects addition on proliferation and migration IPEC-J2 cells Rac1/PLC-γ1 cell migration. We showed that inhibitors Rac1 (NSC-23766) PLC-γ1 (U73122) reduced decreased protein levels in cells. Moreover, promoted cells, is, µM exhibited best effect, treatment increased PLC-γ1....
Introduction: Orthodontic tooth movement occurs as a consequence of paradental tissue remodeling in response to applied mechanical forces. Retention is necessary procedure prevent relapse when orthodontic appliances are removed. Developing new methods promote stability and retention following treatment has always been desired. Recent studies have demonstrated the favorable effects low magnitude, high frequency (LMHF) vibration on bone homeostasis through an ability stimulate cell metabolism...
Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to imbalance growth retardation, thereby causing piglet development. Spermine reduce stress. However, the mechanism of spermine modulating integrity in pigs remains largely unknown. This study aims examine whether protects barrier piglets through ras-related C3 botulinum toxin substrate 1 (Rac1)/phospholipase C-γ1 (PLC-γ1) signaling pathway. In vivo, 80 were categorised into 4 control groups...
To investigate the effect of electroacupuncture (EA) at "Dazhui" (GV14) and "Ciliao" (BL32) on rats with bladder detrusor hyperreflexia (DH) after supersacral spinal cord transection, as well mechanism EA in improving urinary function by regulating expression Wnt-1, β-catenin Neurogenin 1(Ngn1).A total 48 female Sprague-Dawley were randomly divided into sham-operation group, model control 12 each group. T10 transection (SCT) was performed surgery. The Basso, Beattie Bresnahan (BBB) score...
Abstract Local activation and long-range inhibition are mechanisms conserved in self-organizing systems leading to biological patterns. A number of them involve the production by developing cell an inhibitory morphogen, but how this gets immune self-inhibition is rather unknown. Under combined nitrogen starvation, multicellular cyanobacterium Nostoc PCC 7120 develops nitrogen-fixing heterocysts with a pattern heterocyst every 10-12 vegetative cells. Cell differentiation regulated HetR which...