A5006111039- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Economic and Financial Impacts of Cancer
- Cardiac pacing and defibrillation studies
- Clinical practice guidelines implementation
- Mechanical Circulatory Support Devices
- Neurological disorders and treatments
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Transplantation: Methods and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Formal Methods in Verification
- Real-Time Systems Scheduling
- Breast Lesions and Carcinomas
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Potassium and Related Disorders
Icahn School of Medicine at Mount Sinai
2022-2025
Mount Sinai Hospital
2023-2025
Cardiovascular Institute of the South
2024
Emory University
2024
Columbia University Irving Medical Center
2020-2023
Flatiron Health (United States)
2021-2022
Iowa State University
2021
Columbia University
2021
Albany Medical Center Hospital
2017-2020
NewYork–Presbyterian Hospital
2020
Lack of a preclinical model primary dystonia that exhibits dystonic-like twisting movements has stymied identification the cellular and molecular underpinnings disease. The classical familial form is caused by DYT1 (ΔE) mutation in TOR1A, which encodes torsinA, AAA+ ATPase resident lumen endoplasmic reticular/nuclear envelope. Here, we found conditional deletion Tor1a CNS (nestin-Cre Tor1aflox/–) or isolated expression mutant torsinA Tor1aflox/ΔE) causes striking abnormal movements. These...
In patients with low-gradient aortic stenosis (AS) and low transvalvular flow, dobutamine stress echocardiography (DSE) is recommended to determine AS severity, whereas the degree of valve calcification (AVC) supposedly correlates severity according current European American guidelines. The purpose this study was assess relationship between AVC as determined using DSE in area <1 cm2 peak velocity <4.0 m/s. All underwent multislice computed tomography quantify AVC. Receiver-operating...
When patients with suspected or known coronary artery disease (CAD) present new worsening ischemic symptoms, initial referral to imaging optimization of guideline directed medical therapy (GDMT) deferral testing are both acceptable management approaches. In this 12-center study, a 19-item survey exploring preferred strategy for symptomatic older adults (≥75 years) without CAD, and major patient clinical factors driving decision making was administered clinicians. There were 96 respondents...
There is growing evidence that COVID-19 can cause cardiovascular complications. However, there are limited data on the characteristics and importance of atrial arrhythmia (AA) in patients hospitalized with COVID-19. Data from 1,029 diagnosed admitted to Columbia University Medical Center between March 1, 2020 April 15, were analyzed. The diagnosis AA was confirmed by 12 lead electrocardiographic recordings, 24-hour telemetry recordings implantable device interrogations. Patients' history,...
The 2017 American College of Cardiology/American Heart Association blood pressure (BP) Hypertension Clinical Practice Guidelines recommends ambulatory BP monitoring to detect masked hypertension. Data on the short-term reproducibility hypertension are scarce. IDH study (Improving Detection Hypertension) enrolled 408 adults not taking antihypertensive medication from 2011 2013. Office and 24-hour were performed 2 occasions, a median 29 days apart. After excluding participants with office...
Background: Nonbacterial thrombotic endocarditis (NBTE) is a rare condition associated with cancer, hypercoagulable state, and systemic emboli including stroke. This report presents case of NBTE metastatic lung adenocarcinoma recurrent strokes despite anticoagulation for prior pulmonary embolism (PE) highlights the challenges in management NBTE. Case: 66-year-old man stage IV non-small cell treated pembrolizumab complicated by immune checkpoint inhibitor (ICI) myocarditis high dose steroids...
274 Background: Clinical decision support (CDS) tools facilitate value based cancer care delivery and can enable measurement of guideline concordance, but be challenging to implement. Flatiron Assist is an EHR-embedded customizable CDS tool which facilitates selection documentation NCCN Guideline concordant Preferred treatment regimens. We assessed performance metrics after the first year use this at eleven sites care. Methods: reviewed all non-small cell lung (NSCLC) orders as entered 11...
Introduction: Atrial fibrillation (AF) is the most common sustained arrhythmia seen in patients with cardiac amyloidosis (CA). Tafamidis, a transthyretin stabilizer, has been associated reductions all-cause mortality and other promising outcomes CA. However, its effect on incidence of AF still remains unknown. Hypothesis: Tafamidis therapy CA lower AF. Methods: A group 200 following at our institution between 2003 2019 were retrospectively reviewed. Baseline characteristics, onset...
381 Background: With the growing complexity and cost of cancer care, adoption oncology pathway tools as clinical decision support (CDS) has increased at point care. These have been shown to improve care quality, reduce variations in healthcare costs. Flatiron Assist (FA) is a customizable CDS tool that embedded electronic health record (EHR) facilitate selection documentation National Comprehensive Cancer Network (NCCN) guideline concordant treatment regimens. The time burden engaging with...
The future of fixed-wing autonomous aircraft operations depends on the availability an appropriate UAS testbed. testbed must be accessible: relatively inexpensive and easy to come by, without requiring long shipping delays from small international companies. It reconfigurable accommodate vast range different sensor packages, payloads, use-cases, flight characteristics needed a broad variety autonomy operations. fix or find replacement parts that will inevitably break during rigorous testing...