A5101795964- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Erythrocyte Function and Pathophysiology
- Eosinophilic Disorders and Syndromes
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Bone and Joint Diseases
- Lymphatic System and Diseases
- Thermal Regulation in Medicine
- Congenital Anomalies and Fetal Surgery
- Autoimmune and Inflammatory Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
- Bone health and treatments
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Therapeutic Uses of Natural Elements
- Salivary Gland Disorders and Functions
- Nerve Injury and Rehabilitation
Hospital General Universitario De Valencia
2008-2021
Hospital Universitario Miguel Servet
2019
Universidad de Cantabria
2017
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2017
Ministerio de Agricultura y Ganadería de Costa Rica
2016
Hospital Universitario Reina Sofía
2015
Instituto Maimónides de Investigación Biomédica de Córdoba
2015
Hospital Universitario Fundación Jiménez Díaz
2015
Hospital Universitario La Paz
2013
Hospital Universitari i Politècnic La Fe
2004
Objectives To analyze whether oxidative stress ( OS ) changes are present in patients with bisphosphonate‐related osteonecrosis of the jaw BRONJ versus controls. Materials and Methods Oxidative was analyzed serum unstimulated saliva three groups: Group 1 consisted 24 who had been treated intravenous bisphosphonates (iv BP s) developed , group 2 20 received iv s did not develop 3 comprised 17 control subjects. Reduced glutathione GSH ), malondialdehyde MDA oxidized GSSG...
We sought to determine the most appropriate method for measuring salivary flow aid diagnosis of Sjögren's syndrome (SS). Specifically, we compared unstimulated whole rate (UWSFR) with stimulated (SWSFR).This case-control study comprised one group 103 patients SS and a control 50 healthy people. measured UWSFR SWSFR in both groups according guidelines established by Navacet [1993].The were significantly lower patient controls (p < 0.01). Among participants group, found decreased 84...
Background . Activating mutations in the RET gene leads to medullary thyroid carcinoma (MTC). Guidelines encourage performing analysis subjects with hereditary and sporadic disease. Materials Methods Design Observational, case series report study. Patients Subjects diagnosed MTC, a thyroidectomy performed single center Costa Rica between years 2006 2015. Diagnosis Follow-Up Pre- postoperative calcitonin, mutation, neck ultrasound tomography were obtained. Results 21 histological diagnosis of...
Systemic lupus erythematosus (SLE) is characterised by increased venous and arterial thrombotic risk. Although antiphospholipid antibodies (APAs) have been shown to be related with tendency in these patients, more than 40% of them, thrombosis occurs without the presence such antibodies. We analysed association events acquired (anticardiolipin (ACAs) anticoagulant (LA)) inherited (antithrombin (AT), protein C (PC), S (PS) deficiencies, factor V Leiden prothrombin G20210A mutation),...
Psoriasis is a systemic inflammatory disorder with increased cardiovascular risk which has been partly attributed to the prevalence of metabolic syndrome (MS). However, contribution rheological alterations scarcely investigated. In 91 psoriasis patients and in 101 healthy volunteers, we determined profile (fibrinogen, blood viscosity erythrocyte aggregation), along lipidic parameters. Patients showed statistically higher BMI, waist, triglycerides, insulin, c-reactive protein (CRP),...
Systemic lupus erythematosus (SLE) is characterised by increased venous and arterial thrombotic risk. Nevertheless, how hemorheological alterations contribute to risk remains a question of debate. We aimed determine the rheological profile in 105 patients with SLE (24 event) healthy controls. determined blood viscosity erythrocyte aggregation along plasma lipids fibrinogen. Although showed lower at 230 s(-1) native hematocrit when compared controls (p < 0.001), differences disappeared after...
Raynaud's phenomenon (RP) is an episodic peripheral circulatory disorder characterized by local artery spams in subjects exposed to cold or emotional stress. It not well-established whether RP patients show altered rheological profile, mostly due patient classification and clinical severity. We aimed compare the hemorheological profile with primary secondary a healthy control group. Eighteen RP, 22 controls, were included study. also divided according presence of digital ulcers (7 with, 33...
The relationship between rheological alterations and systemic sclerosis (SSc) is not well established. We have determined in 27 patients with SSc (4 male, 21 female ) aged 59 +/- 14 years a matched control group the whole profile, i.e. blood viscosity (BV), plasma (PV), erythrocyte aggregation (EA), deformability (ED) along fibrinogen (Fbg), C-reactive protein (CRP), lipids, indices. Patients show higher Fbg, PV EA (P<0.01) lower ED (P<0.01). A negative significant correlation was found...
The association between hyperhomocysteinemia (HHcy) and Raynaud's phenomenon (RP) remains a matter of debate. In 18 primary RP, 23 secondary RP 41 controls, we investigated homocysteine (Hcy) levels along with biochemical inflammatory parameters. Hcy in both were elevated when compared controls (p < 0.05 p 0.01, respectively). As age was higher as 0.01), age-matched corresponding control group, maintaining its statistical significance 0.05). No differences creatinine, B12 vitamin or folic...
<h3>Background</h3> Biological therapies have greatly improved the management of psoriatic arthritis (PsA). Minimal disease activity (MDA) has become optimal target in treatment PsA, waiting for a standardized definition remission. Knowing proportion PsA patients MDA state could inform on quality these patients. <h3>Objectives</h3> To determine prevalence (Coates et al.) with Spain as well its potential predictors. evaluate association between and impact disease, evaluated by Impact Disease...
<h3>Background</h3> Macrophages play a key role in the pathogenesis of rheumatoid arthritis (RA). Under certain stimulus conditions these cells are able to switch their phenotypes M1 or M2 states, which characterized by different inflammatory and tissue repair properties. Thus, macrophages predominantly recruited states associated with tisular damage. An imbalance M1/M2 proportion has been reported synovium RA patients. The molecular mechanisms undertaken this phenotypic switching not...
Kollmann, Camaiora A.; Del Blanco, B.; Alsina, E.; Brogly, N.; Calvo, J. M.; Gilsanz, F. Author Information
Introduction: Heat stroke is a situation conditioned by the inability of body to dissipate excess heat produced physical exercise. The association liver damage not rare, but some patients may progress fulminant hepatic failure (FHF) requiring transplantation. So far, only 5 exertional cases transplantation have been reported in literature. Patients and methods: We performed retrospective review all undergone our department we found 2 which etiology was stroke. Results: first case man 23...
<h3>Objectives</h3> To identify the factors that are related with response to Apremilast(APR) in Psoriatic Arthritis(PsA). <h3>Methods</h3> An observational and analytical multicenter retrospective study. There included PsA patients treated APR after two years of commercialization. Clinical demographic data were collected: disease duration, previous treatments, cutaneous joint involvement pattern defined as: exclusively, non mixed (by several domains combination). It was duration treatment,...
Background: Heparin is a widely used drug. The most frequent complication derived from its use the haemorrhage. However, an uncommon but potentially serious adverse effect heparin‐induced thrombocytopenia (HIT). goal of treatment HIT to reduce platelet activation and thrombin formation decrease risk thrombosis. Argatroban drug choice in patients as alternative anticoagulant critically ill with high haemorrhage, postoperative cardiac events or renal failure, since it allows close control...
Background: Objectives: Analyse the effect of secukinumab in terms patient´s own variables, specifically: fatigue, sleep, pain and quality life patients with psoriatic arthritis or spondyloarthritis. Methods: A multicentric longtitudinal observational prospective study was carried out at 6 months who begin treatment secukinumab. At start after following data collected on outcome: through an visual analogue scale (VAS), fatigue using FACIT-fatigue scale, sleeping problems insomnia severity...