A5051934799- Morphological variations and asymmetry
- Forensic Anthropology and Bioarchaeology Studies
- Pleistocene-Era Hominins and Archaeology
- Mosquito-borne diseases and control
- Evolution and Paleontology Studies
- Craniofacial Disorders and Treatments
- Medical and Biological Sciences
- Birth, Development, and Health
- Child Nutrition and Water Access
- dental development and anomalies
- Biocrusts and Microbial Ecology
- Marine Toxins and Detection Methods
- Dental Radiography and Imaging
- Advanced MRI Techniques and Applications
- Viral Infections and Vectors
- Pregnancy and preeclampsia studies
- Advanced Neuroimaging Techniques and Applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Comparative Animal Anatomy Studies
- Bone Metabolism and Diseases
- Orthodontics and Dentofacial Orthopedics
- Neurological disorders and treatments
- Gestational Diabetes Research and Management
- Insect symbiosis and bacterial influences
- Neuroinflammation and Neurodegeneration Mechanisms
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2025
Universidad Nacional de La Plata
2010-2025
Hospital El Cruce
2019-2025
Universidad Nacional Arturo Jauretche
2022-2025
Colciencias
2023
Instituto de Neurología Cognitiva
2018-2021
Universidade Federal do Rio de Janeiro
2018-2020
Centro Científico Tecnológico - La Plata
2016-2020
Bariloche Atomic Centre
2018
Centro Científico Tecnológico - San Juan
2012-2018
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital syndrome (CZS). The prevalence this varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance protein malnutrition for emergence CZS. Epidemiological data from outbreak in Americas suggest relationship between undernutrition and cases microcephaly. To experimentally examine relationship, use...
The northeast (NE) region of Brazil commonly goes through drought periods, which favor cyanobacterial blooms, capable producing neurotoxins with implications for human and animal health. most severe dry spell in the history occurred between 2012 2016. Coincidently, highest incidence microcephaly associated Zika virus (ZIKV) outbreak took place NE during same years. In this work, we tested hypothesis that saxitoxin (STX), a neurotoxin produced South America by freshwater cyanobacteria...
Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in growth. Here we demonstrated vivo the impact of congenital ZIKV infection blood vessel development, crucial step organogenesis. was injected intravenously pregnant type 2 interferon (IFN)-deficient mouse at embryonic day (E) 12.5. The embryos were collected E15.5 and postnatal (P)2. Immunohistochemistry for cortical progenitors neuronal markers showed both populations...
Mechanisms of resource allocation are essential for maternal and fetal survival, particularly when the availability nutrients is limited. We investigated responses feto-placental development to chronic protein malnutrition test hypothesis that low diet produces differential growth restriction placental tissues, adaptive changes in placenta may mitigate impacts on growth. C57BL/6J female mice were fed either a low-protein (6% protein) or control isocaloric (20% protein). On embryonic days...
ABSTRACT Objective To analyze food insecurity (FI) in pregnant women from the Metropolitan Area of Buenos Aires (AMBA) and its association with socio‐economic variables nutritional status, as well to identify dietary patterns experiencing moderate severe FI. Methods Between July 2021 September 2023, an observational cross‐sectional study was performed. Data 349 recorded public health centers disadvantaged urban areas. FI assessed Food Insecurity Experience Scale (FIES), status evaluated...
This work assesses cranial vault thickness (CVT) ontogenetic changes using a computed tomography database to register across multiple regions.Vault images of 143 individuals from 0 31 years old were analyzed by semiautomatic measurements. For each individual, we obtained mean measure (TMM) and its coefficient variation, endocranial volume (EV), the distribution relative frequencies thickness-relative frequency polygon, topographic mapping that shows arrangement through chromatic scale....
ABSTRACT Objectives One of the biggest challenges in study complex morphologies is to adequately describe shape variation. Here, we assess how random sampling surface points automatically obtained performs, when compared with observer‐guided procedures, and also evaluate effect sliding by bending energy minimum Procrustes distance. Material methods Three datasets comprising structures disparate levels complexity intrasample variation are as follows: mouse molars, brains, primate endocasts....
To investigate the association between anthropometric status at birth and brain bone growth during first year of life. According to brain-sparing hypothesis, we expect catch-up be faster in head circumference (HC) than body length.
Abstract The northeast (NE) region of Brazil commonly goes through drought periods, which favor cyanobacterial blooms, capable producing neurotoxins with implications for human and animal health. most severe dry spell in the history occurred between 2012 2016. Coincidently, highest incidence microcephaly associated Zika virus (ZIKV) outbreak was described NE during same years. In this work, we tested hypothesis that saxitoxin (STX), a neurotoxin produced South America by freshwater...
Most studies on craniofacial morphology have focused adult individuals, but patterns of variation are the outcome genetic and epigenetic variables that interact throughout ontogeny. Among cranial regions, orbits exhibit morphological occupy an intermediate position between neurocranial facial structures. The main objective this work was to analyze postnatal ontogenetic covariation in orbital region a cross-sectional series humans from 0 31 years old. Landmarks semilandmarks were digitized...
Patterns of covariation result from the overlapping effect several developmental processes.By perturbing certain specific processes, experimental studies contribute to a better understanding their particular effects on generation phenotype.The aim this work was analyze interactions among morphological traits skull and brain during late prenatal life (18.5 days postconception) in mice exposed maternal protein undernutrition.Images were obtained through micro-computed tomography 3D landmark...
Abstract Osteoderms are present in a variety of extinct and extant vertebrates, but among mammals, the presence osteoderms is essentially restricted to armadillos (Cingulata, Dasypodidae). have been proposed exhibit functionalities Dasypodidae, mainly protection thermoregulation, they considered as one synapomorphies this group. In study, we use high‐resolution microcomputed tomography describe osteoderm micromorphology several species Dasypodidae comparative context. This study allowed...
Nutrition is one of the most influential environmental factors affecting development different tissues and organs. It suggested that under nutrient restriction growth brain relatively spared due to differential allocation resources from other However, it not clear whether this sparing occurs brain-wide. Here, we analyze morphological changes cell composition in regions offspring mouse after maternal exposure during pregnancy lactation. Using high resolution magnetic resonance imaging, found...
The skull is considered a modular structure in which different parts are influenced by factors and, as result, achieve adult shape at ages. Previous studies have suggested that the basicranium presents pattern distinguishes sagittal and lateral parts, probably affected brain masticatory structures, respectively. vault of modern humans, contrast, has been highly integrated system mainly growth. Here, we explored developmental variation ectocranial humans order to assess if both regions...
El comportamiento alimentario comprende el conjunto de acciones que llevan al consumo determinados alimentos, y está modelado por aspectos biológicos, psicológicos socio-culturales. En ese sentido, acceso a diferentes nutrientes en todas las etapas la vida, incluyendo prenatal, es variable dependiente del contexto. La exposición condiciones ambientales adversas, como una ingesta inadecuada nutrientes, puede impactar salud materna, crecimiento desarrollo prenatal. objetivo presente trabajo...