The purpose of this study was to evaluate the role CEA after neoadjuvant chemoradiotherapy in patients with rectal cancer.This involved 109 cancer who were treated preoperative and curative resection. Preoperative serum levels measured twice, before administration 4 weeks chemoradiotherapy. Surgery performed 6 9 chemoradiotherapy.The 3-year disease-free survival rate 85.0%. On univariate analysis, prechemoradiotherapy level, postchemoradiotherapy tumor regression grade, ypT, ypN,...

Triple-negative breast cancer (TNBC) shows aggressive clinical behavior, but the treatment options are limited due to lack of a specific target. TNBC shares many and pathological similarities with BRCA-deficient cancer, for which poly(ADP-ribose) polymerase (PARP) inhibitor is effective, PARP alone failed show effects in patients sporadic TNBC. Radiation induces DNA double-strand breaks, phosphoinositide 3-kinase (PI3K) signaling pathway has been known regulate steady-state levels homologous...

The purpose of this study is to evaluate objective cosmetic outcomes and factors related breast-conserving therapy (BCT) using the BCCT.core software. Fifty-one patients who received BCT with informed consent were evaluated Patients divided into two groups based on BCCT score: excellent or good (n=42) vs. fair poor (n=9). Analysis clinical was performed determine affecting outcomes. outcome measured software in 10% patients, 72%, 18%. None classified as outcome. Tumor characteristics,...

To evaluate the efficacy and toxicity of definitive radiotherapy with or without chemotherapy for T3-4 squamous cell carcinoma maxillary sinus nasal cavity. Forty-two patients T3-4N0 (n = 30) cavity 12) received radiotherapy. Chemotherapy was used in 34 elective neck irradiation not used. The 5-year overall survival/local control rates were 34%/29% cancer 50%/52% cancer. For cancers, a performance status Eastern Cooperative Oncology Group ≥2 (P 0.012), biologically equivalent dose <68 Gy...

Radiological properties of newly introduced and existing 3-dimensional (3D) printing materials were evaluated by measuring their Hounsfield units (HUs) at varying infill densities. The six for 3D which consisted acrylonitrile butadiene styrene (ABS), a unique ABS plastic blend manufactured Zortrax (ULTRAT), high impact polystyrene (HIPS), polyethylene terephthalate glycol (PETG), polylactic acid (PLA), thermoplastic polyester elastomer (FLEX) used. We used computed tomography (CT) imaging to...

We investigated the patterns of failure and prognostic factors for locoregional control (LRC) in patients with upper urinary tract (UUT) transitional cell carcinoma (TCC) treated radical surgery to evaluate role adjuvant radiotherapy.We retrospectively reviewed medical records 76 TCC renal pelvis ureter without distant metastasis who underwent curative-intent surgery. No or occurred 19 pTa-1 tumor, we evaluated 57 pT2 more tumors. Adjuvant chemotherapy was applied 25 patients.Recurrences a...

Elderly patients derive similar benefits from 5-fluorouracil-based adjuvant chemotherapy in Stage III colon cancer; however, conflicting data exist regarding additional benefit oxaliplatin, fluorouracil and leucovorin (FOLFOX) chemotherapy. Single-center, retrospective analysis was performed to compare the safety efficacy of leucovorin-4 older (age ≥65 years) with younger cancer after surgical resection. Among 391 cancer, 229 received (87 (43.5%) years old versus 142 (74.3%) <65 old). Older...

The purpose of this study was to evaluate neck control outcomes after definitive radiochemotherapy without planned dissection in node-positive head and cancer.We retrospectively reviewed medical records fifty patients with cancer who received radiochemotherapy. Twelve subsequently underwent for suspicious recurrent or persistent disease. A median dose 70 Gy (range 60-70.6) delivered involved nodes. Response evaluation performed at a 5 weeks completion radiotherapy.Neck failure observed 11...

PURPOSE: The purpose of this study was to evaluate the short-term preoperative effects neoadjuvant chemoradiation on anorectal function, excluding bias postoperative impairment. METHODS: We analyzed 80 patients whom manometry data were available for both prechemoradiation and postchemoradiation. Patients divided into 2 groups according tumor location; lower rectum (n = 52) mid 28). paired t test used compare postchemoradiation parameters including mean resting pressure, maximum squeeze...

Purpose: This study assessed and compared the dosimetric performance of HyperArc RapidArc in stereotactic radiosurgery (SRS) for a single brain metastasis.Methods: Twenty patients with intracranial metastases, each presenting distinct target volume, were retrospectively selected.Subsequently, volumetric modulated arc therapy (VMAT) plans designed using (VMAT RA ) HA patient.For planning comparisons, dose-volumetric histogram (DVH) parameters volumes (PTVs) normal regions computed across all...

Purpose: To evaluate the clinical outcomes and prognostic factors in retroperitoneal soft tissue sarcomas treated by postoperative radiotherapy. Materials Methods: The records of 23 patients with sarcomas, who underwent radiotherapy between 1985 2003, were analyzed. median follow-up period was 77 months (range, 8∼240 months). A total 21 presented primary dise ase, two recurrent disease. Liposarcomas leiomyosarcomas represented 78% diagnosed tu- mor cases. Moreover, 17 cases high grade (grade...

We evaluated the performance of various detectors for small-field dosimetry with field sizes defined by a high-definition (HD) multileaf collimator (MLC) system. For dosimetry, diodes referred to as “RAZOR detectors,” MOSFET detectors, and Gafchromic EBT3 films were used in this study. less than 1×1 cm2, percent depth doses (PDDs) lateral profiles measured diodes, films, absolute measurements conducted detectors. comparison purposes, same carried out size 10×10 cm2. The dose distributions...

Abstract The objectives of this study were to develop a frameless immobilization system that allows roll rotation corrections and investigate the performance for stereotactic radiosurgery (SRS) treatment. We designed support frame based on commercial Brainlab system. consisted fixed component rotating component. With rack pinion gears guide holes installed in system, was configured be rotated along longitudinal axis patient with respect To evaluate six degree-of-freedom (6D) positioning...

Purpose We evaluated the effect of high dose involved field radiotherapy and concurrent chemotherapy for treating patients with limited disease, small cell lung cancer. Materials Methods reviewed medical records 37 who had a stage All were treated induction followed by definitive chemotherapy. The radiation was 60 Gy 31 50∼58 6 once-daily 2 fractions. Elective nodal irradiation not performed. regimen either combinations etoposide cisplatin or irinotecan cisplatin. Prophylactic cranial 25 at...

Abstract Purpose: Pre-operative chemoradiation therapy (CRT) is standard treatment in clinical stage T3/4 or node positive rectal cancer, however, there are no established biomarker that can predict pathological response and outcome to CRT. The aim of this study was evaluate the correlation between expression molecular markers outcomes patients with cancer who received 5-FU based chemoradiotherapy. Experiment design: Immunohistochemical stain performed tissue arrays constructed from core...

Other SectionsAbstractIntroductionMaterials and MethodsResultsDiscussionConclusionsAcknowledgementsConflicts of InterestAvailability Data MaterialsAuthor ContributionsReference