A5043088924- Bacteriophages and microbial interactions
- Burkholderia infections and melioidosis
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Insect symbiosis and bacterial influences
- Vaccine Coverage and Hesitancy
- Vibrio bacteria research studies
- Plant Virus Research Studies
- Sinusitis and nasal conditions
- Aquaculture disease management and microbiota
- Microbial bioremediation and biosurfactants
- Bee Products Chemical Analysis
- Bacterial Identification and Susceptibility Testing
- Hepatitis B Virus Studies
- Animal and Plant Science Education
- Pediatric Hepatobiliary Diseases and Treatments
- Legume Nitrogen Fixing Symbiosis
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Ear Surgery and Otitis Media
- Monoclonal and Polyclonal Antibodies Research
- Insect Utilization and Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
Khon Kaen University
2010-2024
A large-scale surveillance is an important measure to monitor the regional spread of antimicrobial resistance. We prospectively studied prevalence and molecular characteristics clinically Gram-negative bacilli, including Escherichia coli , Klebsiella pneumoniae Acinetobacter baumannii complex (ABC), Pseudomonas aeruginosa from blood, respiratory tract, urine, sterile sites at 47 hospitals across Thailand.
Cholangiocarcinoma (CCA), an epithelial biliary tract malignancy, is a significant health concern in the Greater Mekong Subregion, particularly northeastern Thailand. Prior to development of advanced stages, CCA typically asymptomatic, thereby limiting treatment options and chemotherapeutic effectiveness. Ursolic acid (UA), triterpenoid derived from plants, was previously discovered inhibit cell growth through induction apoptosis. Nevertheless, therapeutic effectiveness UA limited by its...
Burkholderia pseudomallei is a Gram-negative saprophytic bacterium that causes severe sepsis with high mortality rate in humans and vaccine not available. Bacteriophages are viruses of bacteria ubiquitous nature. Several lysogenic phages spp. have been found but information scarce for lytic phages. Six phages, ST2, ST7, ST70, ST79, ST88 ST96, which lyse B. pseudomallei, were isolated from soil an endemic area. The belong to the Myoviridae family. range estimated genome sizes 24.0-54.6 kb....
Abstract Black soldier fly (BSF, Hermetia illucens ) is popular for its applications in animal feed, waste management and antimicrobial peptide source. The major advantages of BSF larva include their robust immune system high nutritional content that can be further developed into more potential agricultural medical applications. Several strategies are now being to exploit fullest capabilities one these the immunity modulation using bacterial challenges. mechanism underlying metabolic...
The lytic phage ST79 of Burkholderia pseudomallei can lyse a broad range its host including antibiotic resistant isolates from within using set proteins, holin, lysB, lysC and endolysin, peptidoglycan (PG) hydrolase enzyme. endolysin gene identified as peptidase M15A was cloned, expressed purified to evaluate potential pathogenic bacteria. molecular size the enzyme is approximately 18 kDa in silico study cited here indicated presence zinc-binding domain predicted be member subfamily A...
To identify and characterize the lysis gene cassette from bacteriophage ST79 that lyses Burkholderia pseudomallei. Approximately 1·5 kb of genes were identified phage genome data. It was composed holin, peptidase M15A or endolysin, lysB lysC. Each its combinations cloned into Escherichia coli lytic effects measured. Co‐expression holin showed highest activity. Expression lysB/C holin‐peptidase M15A‐lysB/lysC lysed E. membrane, whereas alone did not. The predicted transmembrane structures...
To compare cerumenolytic effects of docusate sodium and 2.5% bicarbonate - In vitro study; observe characteristics the solution, using ultraviolet-visible (UV/Vis) spectroscopy, measurement cholesterol levels. Samples human cerumen were mixed to form a relatively homogenous paste. about 500 mg weighed packed at bottom test tubes. each tube was added 1.5 ml either or bicarbonate. Tubes incubated 36.4 °C in water bath for 15, 30 60 min. Following incubation, supernatant solution pipetted into...
Phage therapy is increasingly considered a viable alternative to combat multi-drug-resistant bacteria, including Acinetobacter baumannii (AB), significant nosocomial pathogen. In this study, an AB isolate, designated ABU-3, was found susceptible three distinct AB-phages, termed AB-phage 22, 27, and 32. The ABU-3 isolate treated with these phages at various multiplicities of infection (MOI) identify the MOI necessary completely eliminate referred as "MOI clearance value."...
Several vaccine programs were introduced during the COVID-19 pandemic, which included inactivated virus, DNA viral vectors and mRNA vaccines. Booster are recommended, especially for those in high-risk groups. However, many of these booster involve heterologous This study enrolled volunteers who first received two full-dose CoronaVac vaccinations before receiving boosters with DNA- and/or mRNA-vaccines an additional 2 doses (n = 40) or 3 16). Our results showed no difference side effects,...