A5080207477- Acute Myeloid Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- Nuclear Structure and Function
- Cellular transport and secretion
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- RNA Research and Splicing
- Muscle Physiology and Disorders
- PI3K/AKT/mTOR signaling in cancer
- RNA regulation and disease
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Hemoglobinopathies and Related Disorders
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Hippo pathway signaling and YAP/TAZ
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
University of Bologna
2015-2024
Lipid signaling pathways are involved in cell growth, differentiation, and apoptosis, could have a role the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). Indeed, recent studies showed that phosphoinositide-phospholipase (PI-PL)Cbeta1 mono-allelic deletion correlates with higher risk AML evolution. Also, single patient treated azacitidine, DNA methyltransferase inhibitor currently used MDS, displayed direct correlation between PI-PLCbeta1 gene expression...
Inositide-specific phospholipase Cbeta1 (PLCbeta1) signaling in cell proliferation has been investigated thoroughly the G(1) cycle phase. However, little is known about its involvement G(2)/M progression. We used murine erythroleukemia cells to investigate role of PLCbeta1 progression and screened a number candidate intermediate players, particularly mitogen-activated protein kinase (MAPK) C (PKC), which can, potentially, transduce serum mitogenic stimulus induce lamin B1 phosphorylation,...
Myelodysplastic Syndromes, a heterogeneous group of haematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis neoplastic growth. Comprehensive knowledge these pathways is crucial for development innovative therapies that aim restore normal apoptosis improve patient outcomes.
Glioblastoma represents the most lethal brain tumor in adults. Several studies have shown key role of phospholipase C β1 (PLCβ1) regulation many mechanisms within central nervous system suggesting PLCβ1 as a novel signature gene molecular classification high-grade gliomas. This study aims to determine pathological impact glioblastoma, confirming that expression correlates with glioma's grade, and it is lower 50 glioblastoma samples compared 20 healthy individuals. silencing cell lines...
Our main goal in this study was to investigate the role of phospholipase C (PLC) beta(1) and PLCgamma(1) skeletal muscle differentiation existence potential downstream targets their signaling activity. To examine whether PLC can modulate expression cyclin D3, a target PLCbeta(1) erythroleukemia cells, we transfected C2C12 cells with vectors containing or cDNA small interfering RNAs from regions gene followed myogenic well-established cell system. Intriguingly, overexpressed were able mimic...
Abstract This study tested the hypothesis that PI-PLCβ1 is associated with myeloid differentiation and its expression could be useful for predicting response of MDS patients to azacitidine, as clinical effect epigenetic treatments often detectable only after several cycles therapy. To this end, was quantified on 70 (IPSS risk: 13 Low, 20 Int-1, 31 Int-2, 6 High) at baseline during first 3 azacitidine. Results were then compared hematologic response, assessed sixth cycle azacitidine Overall,...
Bone morphogenetic protein 2 (BMP-2) is a critical growth factor that directs osteoblast differentiation and bone formation. Phosphoinositide-phospholipase Cβ 1 (PLCβ1) plays crucial role in the initiation of genetic program responsible for muscle differentiation. Differentiation C2C12 mouse myoblasts response to insulin stimulation characterized by marked increase nuclear PLCβ1. Here, function PLCβ1 osteogenic was investigated. Briefly, cells treated with BMP-2 we assist remarkable mRNA...
Although TNF-related apoptosis-inducing ligand (TRAIL) usually induces cell death in tumor cells, there are some types that resistant to its apoptogenic effects. Some chemotherapeutic drugs, however, can sensitize cancer cells TRAIL by either upregulating surface receptor expression or modulating intracellular signalling pathways emanating from receptors. U2OS human osteosarcoma express TRAIL-R2 but TRAIL-induced apoptosis. the genotoxic Doxorubicin and Cisplatin, able TRAIL, without...