A5055240267- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Mycology
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Hemoglobinopathies and Related Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Pleural and Pulmonary Diseases
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Infective Endocarditis Diagnosis and Management
Ca' Foncello Hospital
2023-2024
Istituto di Ematologia di Bologna
2007-2022
Ospedali Riuniti di Foggia
2022
Policlinico S.Orsola-Malpighi
2011-2021
University of Bologna
2011-2021
Istituto Oncologico Romagnolo
1998-2016
Medica (Italy)
2007
Columbia University Irving Medical Center
2006
The University of Texas MD Anderson Cancer Center
2003-2004
University of Pisa
2004
Background The aim of this study was to evaluate prognostic factors, treatments and outcome invasive aspergillosis in patients with acute myeloid leukemia based on data collected a registry.Design Methods registry, which activated 2004 closed 2007, leukemia, admitted 21 hematologic divisions tertiary care centers or university hospitals Italy, who developed proven probable aspergillosis.Results One hundred forty cases were collected, most occurring during the period post-induction aplasia,...
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a multisystemic autosomal recessive disease due to primary thymidine phosphorylase (TP) deficiency. To restore TP activity, we performed reduced intensity allogeneic stem cell transplantations (alloSCTs) in two patients. In the first, alloSCT failed engraft, but second achieved mixed donor chimerism, which partially restored buffy coat activity and lowered plasma nucleosides. Thus, can correct biochemical abnormalities blood of...
Epidemiologic investigation of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be useful to identify subpopulations who might benefit from targeted treatment strategies. The Gruppo Italiano Trapianto Midollo Osseo (GITMO) prospectively registered data on 1858 consecutive patients undergoing allo-HSCT between 2008 and 2010. Logistic regression analysis was performed risk factors for proven/probable IFD (PP-IFD) during the early (days 0...
The aims of the study were to analyze clinical and epidemiological characteristics treatments for patients who developed zygomycosis enrolled in italy during european Confederation medical mycology survey. This prospective multicenter was performed between 2004 2007 at 49 italian Departments. 60 cases enrolled: median age 59.5 years (range 1-87), with a prevalence males (70%). majority immunocompromised (42 cases, 70%), mainly hematological malignancies (37). Among non-immunocompromised (18...
Background. Computed tomography pulmonary angiography (CTPA) may improve the diagnostic capabilities of CT imaging for invasive mold disease, but its performance relative to other signs (ie, halo sign, hypodense pleural effusion, reversed sign) is unknown. Methods. We prospectively compared CTPA vs findings in 100 patients with hematological malignancies and possible disease defined by EORTC/MSG criteria. After undergoing extensive work-up, were upgraded probable or proven based on...
Background. Invasive mold diseases (IMDs) of the lung remain a challenge for immunocompromised patients. Although timely diagnosis and treatment are crucial outcome infection, poor sensitivity microbiological techniques limited specificity chest high-resolution computed tomography (HRCT) often delay definitive these infections.
BackgroundA risk score for invasive mold disease (IMD) in patients with hematological malignancies could facilitate patient screening and improve the targeted use of antifungal prophylaxis. MethodsWe retrospectively analyzed 1,709 hospital admissions 840 (2005-2008) to collect data on 17 epidemiological treatment-related factors IMD. Multivariate regression was used develop a weighted based independent associated proven or probable IMD, which prospectively validated during 1,746 855 from...
Abstract Aspergillus fumigatus (AF) is a ubiquitous mold and the most common cause of invasive aspergillosis (IA) in immunocompromised patients. In stem cell transplant recipients, IA now occurs frequently setting therapy with corticosteroids, including methylprednisolone (MP). We showed previously that gliotoxin (GT), an AF-derived mycotoxin, induces apoptosis monocytes dendritic cells, resulting suppression AF-specific T responses. examined ability GT to induce polymorphonuclear leukocytes...
Objective The aims of the present study were to evaluate clinical significance delay for surgical treatment and prognostic value other clinical, pathologic, microbiological variables among hematologic patients affected by acute invasive fungal rhinosinusitis (AIFRS). Furthermore, we propose our early diagnosis protocol, reporting its 10-year results. Study Design Monocentric retrospective analysis. Setting was conducted from 2001 2017 at University Hospital Bologna, Italy. Subjects Methods...
Abstract This study tested the hypothesis that PI-PLCβ1 is associated with myeloid differentiation and its expression could be useful for predicting response of MDS patients to azacitidine, as clinical effect epigenetic treatments often detectable only after several cycles therapy. To this end, was quantified on 70 (IPSS risk: 13 Low, 20 Int-1, 31 Int-2, 6 High) at baseline during first 3 azacitidine. Results were then compared hematologic response, assessed sixth cycle azacitidine Overall,...
Human dendritic cells (DC) comprise 2 subsets-plasmacytoid CD123(+) and myeloid CD11c(+) DC-that may have distinct roles in the regulation of immunity after allogeneic hematopoietic stem cell transplantation. In this study, we analyzed kinetics DC reconstitution 31 patients who underwent transplantation with granulocyte colony-stimulating factor-mobilized peripheral blood (PB) from HLA-identical sibling donors myeloablative conditioning. Lineage marker-negative HLA-DR(+) lineage DC, as well...
The monitoring of minimal residual disease (MRD) through low sensitivity real-time (RT) polymerase chain reaction (PCR) analysis BCR-ABL transcripts allows early detection chronic myeloid leukemia (CML) relapse after allogeneic hematopoietic stem cell transplantation (HSCT). introduction more sensitive techniques, such as RT quantitative (Q)-PCR, may lead to an overestimation the risk CML relapse. In this study, we reviewed results peripheral blood Q-PCR in patients who underwent HSCT from...