A5033567573- Dental materials and restorations
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Endodontics and Root Canal Treatments
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Dental Erosion and Treatment
- Dental Implant Techniques and Outcomes
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Dental Trauma and Treatments
- Lymphatic System and Diseases
- Cancer Mechanisms and Therapy
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Dental Radiography and Imaging
- Retinal Diseases and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
Heidelberg University
2014-2023
University Hospital Heidelberg
2006-2023
Clinical Research Management
2016
University Medical Centre Mannheim
2002-2009
Charité - Universitätsmedizin Berlin
2009
University of Mannheim
2005
Universitäts-HNO-Klinik Heidelberg
1999
Destruction of existing tumor blood vessels may be achieved by targeting vascular endothelial growth factor (VEGF) signaling, which mediates not only cell proliferation but also survival. In this study, however, intravital microscopy failed to demonstrate that VEGFR-2 (by the tyrosine kinase inhibitor SU5416) induces significant regression experimental vessels. Immunohistochemistry, electron microscopy, expression analyses, and in situ hybridization provide evidence resistance is conferred...
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular events underlying gliomagenesis are poorly understood. In this study, we have identified receptor tyrosine kinase Axl as a mediator glioma growth invasion. We demonstrate that its ligand Gas6 overexpressed in human cell lines is activated under baseline conditions. Furthermore, expressed at high levels malignant glioma. Inhibition signaling by overexpression...
Abstract Tumor dormancy has important implications for early detection and treatment of cancer. Lack experimental models limited clinical accessibility constitute major obstacles to the molecular characterization dormant tumors. We have developed in which human tumors remain a prolonged period time (>120 days) until they switch rapid growth become strongly angiogenic. These angiogenic retain their ability grow fast once injected new mice. hypothesized that undergo stable genetic...
Tumors have been thought to initiate as avascular aggregates of malignant cells that only later induce vascularization. Recently, this classic concept tumor angiogenesis has challenged by the suggestion grow co-opting preexisting host vessels and thus well-vascularized tumors without triggering angiogenesis. To discriminate between these two mechanisms, we used intravital epifluorescence microscopy multi-photon laser scanning confocal visualize C6 microglioma vascularization cell behavior....
Tumors have been thought to initiate as avascular aggregates of malignant cells that only later induce vascularization. Recently, this classic concept tumor angiogenesis has challenged by the suggestion grow co-opting preexisting host vessels and thus well-vascularized tumors without triggering angiogenesis. To discriminate between these two mechanisms, we used intravital epifluorescence microscopy multi-photon laser scanning confocal visualize C6 microglioma vascularization cell behavior....
The aim of the study was to determine source vascular endothelial growth factor (VEGF) in hematoma fluid patients suffering from chronic subdural (CSH) and identify level gene expression pro-angiogenic factors angiopoietin 1 (ANG-1) ANG-2 membranes. Samples venous blood, fluid, outer membrane were obtained during surgery for CSH. numbers mononuclear cells determined blood samples taken 11 patients. concentration VEGF measured by ELISA technique plasma. RT-PCR methodology used different mRNA...
The goal of this study was to determine the effects SU6668, a polyvalent receptor tyrosine kinase inhibitor against vascular endothelial growth factor receptor-2, platelet-derived receptor-beta, and fibroblast factor-1 on tumor growth, angiogenesis, microcirculation in an orthotopic malignant glioma model.Fluorescently labeled C6 cells were implanted into long-term cranial window, which had been prepared nude mice. animals treated with intraperitoneal injections SU6668 (75 mg/kg/day)...
During orthodontic tooth movement, the application of adequate forces allows teeth to be moved through alveolar bone. These are transmitted periodontal ligaments (PDL) supporting bone and lead deposition or resorption bone, depending on whether tissues exposed a tensile compressive mechanical strain. Fibroblasts within PDL (PDLF) considered mechanoresponsive. The transduction mechanisms from loading PDLF initiation remodeling not clearly understood. Recently, members ephrin/Eph family have...
Members of the ephrin/Eph family have recently been shown to be involved in regulation bone homeostasis a murine model. The activation EphB4 receptor on osteoblasts by its ligand ephrin-B2 led stimulation osteoblastogenesis and therefore formation. ephrin-A2-EphA2 signaling inhibited osteoblast-specific gene expression, leading resorption. Fibroblasts within periodontal ligament may one first responders orthodontic forces. Periodontal fibroblasts (PDLF) are mechanoresponsive. might link...
Pericyte loss and capillary regression are characteristic for incipient diabetic retinopathy. recruitment is involved in vessel maturation, ligand-receptor systems contributing to pericyte survival factors endothelial cells pericyte-free vitro systems. We studied relation the susceptibility toward hyperoxia-induced vascular remodeling using reporter X-LacZ mouse model of retinopathy prematurity (ROP). Pericytes were found close proximity vessels, both during formation superficial deep...
Orthodontic retainers should restrict physiological tooth mobility as little possible. While this has been investigated for multistranded retainers, there is a lack of data novel CAD/CAM retainers. To address this, the present study compared restriction in and different
Ephrin-A2–EphA2 and ephrin-B2–EphB4 interactions have been implicated in the regulation of bone remodeling. We previously demonstrated a potential role for members Eph-ephrin family receptor tyrosine kinases remodeling during orthodontic tooth movement: compression-dependent upregulation ephrin-A2 fibroblasts periodontal ligament (PDL) attenuated osteogenesis osteoblasts alveolar bone. However, factors affecting expression upon application compressive forces remained unclear. Here, we report...
Background: Induced tooth movement during orthodontic therapy requires mechano-induced bone remodeling. Besides various cytokines and growth-factors, neuronal guidance molecules gained attention for their roles in homeostasis thus, potential movement. Several have been implicated the regulation of Amongst them, Semaphorin 3A is particular interesting as it concurrently induces osteoblast differentiation disturbs osteoclast differentiation. Methods: Mechano-regulation Sema3A its receptors...