A5077839950- Environmental Toxicology and Ecotoxicology
- Cellular transport and secretion
- Pesticide Exposure and Toxicity
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Ubiquitin and proteasome pathways
- Plant Molecular Biology Research
- Photochromic and Fluorescence Chemistry
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Pesticide and Herbicide Environmental Studies
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Labor Law and Work Dynamics
- Trace Elements in Health
- Cholinesterase and Neurodegenerative Diseases
- Vitamin C and Antioxidants Research
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- 3D Printing in Biomedical Research
- ATP Synthase and ATPases Research
- Calcium signaling and nucleotide metabolism
Consejo Nacional de Investigaciones Científicas y Técnicas
2008-2025
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2008-2024
Universidad Nacional de Córdoba
2015-2022
Istituto Superiore per la Protezione e la Ricerca Ambientale
2011-2018
Fundación Ciencias Exactas y Naturales
2018
University of Buenos Aires
2018
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2006-2008
Axonal elongation is one of the hallmarks neuronal polarization. This phenomenon requires axonal membrane growth by exocytosis plasmalemmal precursor vesicles (PPVs) at nerve cone, a process regulated IGF-1 activation PI3K (phosphatidylinositol-3 kinase) pathway. Few details are known, however, about targeting mechanisms for PPVs. Here, we show, in cultured hippocampal pyramidal neurons and cones isolated from fetal rat brain, that activates GTP-binding protein TC10, which triggers...
Delta-catenin is a synaptic adherens junction protein pivotally positioned to serve as signaling sensor and integrator. Expression of delta-catenin induces filopodia-like protrusions in neurons. Here we show that the small GTPases Rho family act coordinately downstream effectors delta-catenin. A dominant negative Rac prevented delta-catenin-induced protrusions, Cdc42 activity was dramatically increased by expression. kinase dead LIMK (LIM kinase) mutant Cofilin also protrusions. To link...
Abstract A well-balanced chromatin dynamic is vital for the survival and physiology of all cells, including brain neurons. Heterochromatin, commonly associated with transcriptional silencing, also plays significant roles in maintaining genomic stability facilitating DNA-repair processes. Notably, bimethylation histone H3 at lysine 9 (H3K9me2), a hallmark repressive heterochromatin, supports axonal specification However, neuronal maintenance H3K9me2 equilibrium remains understudied. In this...
In this study, we have examined the effects of rotenone in primary cultures hippocampal and dopaminergic neurons order to obtain insights into possible mechanisms underlying neurotoxic pesticide. The results obtained indicate that a 48-h exposure (0.1μM) produces complete selective suppression axon formation. This effect was dose dependent, not accompanied by changes microtubule organization, reversible after washout agrochemical from tissue culture medium. Interestingly, pull-down assays...
Abstract Mechanical stimuli play a key role in many cell functions such as proliferation, differentiation and migration. In the mammary gland, mechanical signals distension of epithelial cells due to udder filling are proposed be directly involved during lactation involution. However, evolution focal adhesions -specialized multiprotein complexes that mechanically connect with extracellular matrix- gland development, well influence involved, remains unclear. Here we present use an equibiaxial...
A bstract Extracellular vesicles (EVs) play a critical role in the development of neural cells central nervous system (CNS). Human rosettes (hNRs) are radial cell structures that assemble from induced pluripotent stem (hiPSCs) and recapitulate some stages tube morphogenesis. Here we show hiPSCs hNRs secrete EVs (hiPSC-EVs hNR-EVs) with distinct protein cargoes. Remarkably, hNR-EVs carry neuronal glial cellular components involved CNS development. By silico analysis, found signature is...
Neurons are highly polarized cells requiring precise regulation of trafficking and targeting membrane proteins to generate maintain different specialized compartments, such as axons dendrites. Disruption the Golgi apparatus (GA) secretory pathway in developing neurons alters axon/dendritic formation. Therefore, detailed knowledge mechanisms underlying vesicles exiting from GA is crucial for understanding neuronal polarity. In this study, we analyzed role Brefeldin A-Ribosylated Substrate...
Ante el crecimiento del tamaño de los tambos, aumento la mano obra contratada, y considerando su importancia en resultados actividad, a partir Teoría Agencia, se postuló hipótesis que establecimientos propicia separación entre propiedad control, originando problemas agencia organización interna lecheros. El objetivo fue describir relacionar arquitectura organizacional región pampeana argentina con e identificar agencia. Se realizó un estudio descriptivo, corte transversal Encuesta Sectorial...