A5062821540- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Natural product bioactivities and synthesis
- Bacterial Infections and Vaccines
- Pharmacological Effects of Natural Compounds
- Synthesis and Biological Evaluation
- Particle Accelerators and Free-Electron Lasers
- Natural Antidiabetic Agents Studies
- Synthesis and Reactions of Organic Compounds
- Piperaceae Chemical and Biological Studies
- Plant tissue culture and regeneration
- Allelopathy and phytotoxic interactions
- Vaccine Coverage and Hesitancy
- Bioactive natural compounds
- Particle accelerators and beam dynamics
- Insect Pest Control Strategies
- Traditional and Medicinal Uses of Annonaceae
- Environmental Sustainability and Education
Universidade Federal do Pará
2014-2024
Fundação Oswaldo Cruz
2013-2022
Natura (Brazil)
2016-2019
Universidade Federal do Rio de Janeiro
2011-2019
Faculdade Brasil
2017-2019
Universidade do Estado do Pará
2016
Universidade Federal de Pernambuco
2014
Information Technology Laboratory
2014
Universidade Federal de São Carlos
2008
Universidade Federal Fluminense
2002-2007
Abstract Cancer profoundly influences morbidity and fatality rates worldwide. Patients often have dismal prognoses despite recent improvements in cancer therapy regimens. However, potent biomolecules derived from natural sources, including medicinal dietary plants, contain biological pharmacological properties to prevent treat various human malignancies. Capsaicin is a bioactive phytocompound present red hot chili peppers. has demonstrated many effects, antioxidant, anti‐inflammatory,...
In response to Salmonella typhimurium , the intestinal epithelium generates an intense inflammatory consisting largely of polymorphonuclear leukocytes (neutrophils, PMN) migrating toward and ultimately across epithelial monolayer into lumen. It has been shown that bacterial-epithelial cell interactions elicit production regulators promote transepithelial PMN migration. Although S. can enter cells, bacterial internalization is not required for signaling mechanisms induce movement. Here, we...
β-LAPACHONE AND DERIVATIVES.Naphthoquinones have been extensively studied due to their activity as topoisomerase inhibitors.These enzymes are critical DNA replication in cells.In addition, naphthoquinones shown induce what known "reactive oxygen species" that can cause damage cells.β-Lapachone is a very important pyranaphthoquinone obtained from the heartwood of lapacho tree, Tabebuia avellanedae Lorentz ex.Griseb.(Bignoniaceae), and other trees native Central South America chemically...
From seeds of Carapa guianensis the Amazon native people extracts andiroba oil, which is traditionally used as febrifuge, anti-malarial, insecticidal and repellant. The non-saponifiable fraction separated from oil rich in limonoids, assigns its pharmacological effects.The limonoid-rich were submitted to vitro antiplasmodial bioassay using W(2) Dd(2) strains Plasmodium falciparum. acute toxicity was evaluated. subjected fractionation identified major constituents.Andiroba inhibited growth...
Understanding the distribution of hundreds thousands plant metabolites across kingdom presents a challenge. To address this, we curated publicly available LC-MS/MS data from 19,075 extracts and developed plantMASST reference database encompassing 246 botanical families, 1,469 genera, 2,793 species. This taxonomically focused facilitates exploration plant-derived molecules using tandem mass spectrometry (MS/MS) spectra. tool will aid in drug discovery, biosynthesis, (chemo)taxonomy,...
Leishmaniasis is an infectious disease caused by various species of the protozoan parasites Leishmania genus and transmitted phlebotomine sandflies. The protozoa multiply in phagocytic cells, mainly macrophages, which play important role defending organism from pathogens. most effective treatment for leishmaniasis chemotherapy besides high cost, these drugs are toxic require a long period treatment. Currently, some herbal products considered alternative source new leishmanicidal agent,...
Shigella flexneri causes bacillary dysentery in humans by invading epithelial cells of the colon, which is characterized an acute polymorphonuclear leukocyte (PMNL)–rich inflammation. Our recent studies demonstrated that cadaverine, a polyamine, specifically acts to abrogate transepithelial signaling PMNL induced S. flexneri. Here, insight provided into cellular mechanisms cadaverine attenuates ability species induce signaling. It was found retards lysis species–containing vacuole,...
Chemical investigation of extracts from the stems and leaves Alchorneopsis floribunda Müll. Arg., collected in Amazon region, was performed. The main isolated compounds were triterpenes (α-amyrin, β-amyrin, lupeol, betulin, betulinic acid, uvaol, erythrodiol oleanolic acid) phenolic acid derivatives 4-hydroxybenzoic (gallic protocatechuic acids isocorilagin). In germination assays, high inhibitory allelopathic effects isocorilagin observed 2,2-diphenyl-1-picrylhydrazyl radical scavenging...
A methanol-water extract of Inga edulis leaves was fractionated to identify the polyphenolic compounds. The identified compounds were gallic acid, catechin, epicatechin, myricetin-3-rhamnopyranoside, quercetin-3-glucopyranoside and quercetin-3-rhamnopyranoside. antioxidant activity pure polyphenols measured by ORAC assay compared with Total Phenolic (TP) content. dry crude presented very high values for (11.16 mmol TE per g) TP (496.5 mg GAE g). responsible 9.53 % 12.10 value content leaf...
Peperomia pellucida is a species known in the Amazon as "erva-de-jabuti" that has been used several therapeutic applications based on folk medicine. Herein, we describe classes, subclasses, and main compounds of leaves, stems, roots from P. by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry associated with molecular networks, mirror plot GNPS library, machine learning. These data show were annotated for first time genus, such...
Salmonella typhimurium elicits an acute inflammatory response in the host intestinal epithelium, characterized by movement of polymorphonuclear leukocytes (PMN) across epithelial monolayer to lumen. It was recently shown that SipA, a protein secreted S. typhimurium, is necessary and sufficient drive PMN transmigration model epithelia (Lee, C. A., Silva, M., Siber, A. Kelly, J., Galyov, E., McCormick, B. (2000) Proc. Natl. Acad Sci. USA 97, 12283–12288). However, factors responsible for this...
ALLELOPATHIC POTENTIAL OF CATECHINS THE Tachigali myrmecophyla (Leguminosae).Two compounds, (+)-catechin and epicatechin, were isolated from leaves of T. myrmecophyla, using chromatographic techniques.The structural identification was carried out on the basis 1 H 13 C NMR spectral data comparison with literature data.The compounds epicatechin submitted to germination inhibition radicle hypocotyl growth assays.Results showed some significant activities confirming initial hypothesis about...
Introduction Parkinson’s disease affects 2% of the population aged over 65 years and is second most common neurodegenerative disorder in general population. The appearance motor symptoms associated with degeneration dopaminergic neurons nigrostriatal pathway. Clinically significant nonmotor are also important for severe disability progression. Pharmacological treatment levodopa, which involves dopamine restitution, results a temporary improvement symptoms. Among mechanisms underlying...
Salmonella typhimurium elicits an intense proinflammatory response characterized by movement of polymorphonuclear neutrophils (PMN) across the epithelial barrier to intestinal lumen. We previously showed that S. typhimurium, via type III secretion system effector protein SipA, initiates ADP-ribosylation factor-6- and phospholipase D-dependent lipid-signaling cascade directs activation kinase C (PKC) subsequent transepithelial PMN. Here we sought determine specific PKC isoforms are induced...
Stryphnodendron pulcherrimum is a species known to have high content of tannins. Accordingly, its preparations are used in southern Pará, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, chemical profile composition remains essentially unknown. We herein describe the compounds present hydro-acetonic extract from S. leaves as revealed by dereplication via ultra-high performance liquid chromatography coupled high-resolution mass spectrometry. The data were combined...
L. (Cucurbitaceae) is a plant known in Brazil as "melão de São Caetano", which has been related to many therapeutic applications folk medicine. Herein, we describe antibacterial activities and metabolites for an extract fractions obtained from the leaves of that species. An ethanolic its three were used perform vitro assays. In addition, liquid chromatography coupled mass spectrometry molecular networking approach metabolite annotation process. Overall, 25 compounds annotated
Species of Swietenia elaborate limonoid chemistry along only one route, which leads to the mexicanolide type in most species and phragmalin S. mahogani. A hexane extract from leaves macrophylla afforded six new phragmalins with a 8,9,30-ortho-ester unit, namely, 6-O-acetylswietephragmin E (1), 3beta-O-destigloyl-3beta-O-benzoyl-6-O-acetylswietephragmin (2), 12alpha-acetoxyswietephragmin C (3), 3beta-O-destigloyl-3beta-O-benzoyl-12alpha-acetoxyswietephragmin (4), D (5), (6). This appears be...