A5056691081- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Neuroscience and Neuropharmacology Research
- Phytochemistry Medicinal Plant Applications
- Ethnobotanical and Medicinal Plants Studies
- Amino Acid Enzymes and Metabolism
- Gene expression and cancer classification
- Biochemical effects in animals
- Wound Healing and Treatments
- Genetics, Bioinformatics, and Biomedical Research
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Piperaceae Chemical and Biological Studies
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- Cell Image Analysis Techniques
Universidade Federal do Pará
2013-2024
Understanding the distribution of hundreds thousands plant metabolites across kingdom presents a challenge. To address this, we curated publicly available LC-MS/MS data from 19,075 extracts and developed plantMASST reference database encompassing 246 botanical families, 1,469 genera, 2,793 species. This taxonomically focused facilitates exploration plant-derived molecules using tandem mass spectrometry (MS/MS) spectra. tool will aid in drug discovery, biosynthesis, (chemo)taxonomy,...
Based on ethnopharmacological studies, a lot of plants, as well its compounds, have been investigated for the potential use wound healing agents. In Brazil, Curatella americana is traditionally used by local people to treat wounds, ulcers and inflammations. However, best our knowledge, traditional in treatment wounds has not validated scientific study. Here, some many them flavonoids, were identified hydroethanolic extract from leaves C. (HECA) LC-HRMS LC-MS/MS. Besides that, solutions...
The neural retina is a highly complex tissue composed of excitatory and inhibitory neurons glial cells.Glutamate, the main neurotransmitter, mediates information transfer from photoreceptors, bipolar cells, ganglion whereas interneurons, mainly amacrine horizontal use γ-aminobutyric acid (GABA), neurotransmitter.In this review we place an emphasis on glutamate GABA transporters as regulated molecules that play fundamental roles in neurotransmitter clearance, release, oxidative stress.We...
The main challenge of plant chemical diversity exploration is how to develop tools study exhaustively tissues. Their sustainable sourcing a limitation as bioguided strategies and dereplication need quite large amounts material. We examine if alternative solutions could overcome these difficulties by obtaining secure, sustainable, scalable source tissues able biosynthesize an array metabolites. As this approach would be independent the botanical origin possible, we chose eight species from...
Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem highly prized for exceptional quality, while leaves are valued their high content of phragmalin-type limonoids, subclass compounds significant biological activities, including antimalarial, antitumor, antiviral, and anti-inflammatory properties. In this context, twelve isolated limonoids S. were employed standards in mass spectrometry-based molecular networking to unveil new potential...
Abstract Introduction : Plants of the genus Phyllanthus ( Euphorbiaceae ), “stone breaker” has long been used in folk medicine to treat hepatitis B, an important viral disease. In this regard some species were tested against viruses as Herpes simplex virus type 1 (HSV-1), COVID and Hepatitis C (HCV), showing expressive inhibition them, attracting attention its chemical constituents. Although P. brasiliensis no traditional use antiviral plant, these findings urge us consider whether , plant...