A5037485097- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Photosynthetic Processes and Mechanisms
- Helminth infection and control
- Parasitic Diseases Research and Treatment
- Bioinformatics and Genomic Networks
- Cell Image Analysis Techniques
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Streptococcal Infections and Treatments
- Circadian rhythm and melatonin
- Parasites and Host Interactions
- Mitochondrial Function and Pathology
- Plant and fungal interactions
- Evolution and Genetic Dynamics
- Reproductive Biology and Fertility
- Algal biology and biofuel production
New York University
2006-2025
New York University Abu Dhabi
2016-2025
Sapienza University of Rome
2006
LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas Drosophila, help localize Vasa helicase to germ granules facilitate piRNA-mediated transposon silencing. The homologous mammals, TDRD5 TDRD7, are required during spermiogenesis. Until now, both domains Caenorhabditis elegans remained elusive. Here we describe LOTR-1 (D1081.7), which derives its name from domains. Interestingly, docks next P colocalize with...
Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock crops. Resistance to few anthelmintic drugs is increasing. Here, we report set avocado fatty alcohols/acetates (AFAs) that exhibit nematocidal activity against four veterinary parasitic nematode species: Brugia pahangi, Teladorsagia circumcincta Heligmosomoides polygyrus, as well multidrug resistant strain (UGA) Haemonchus contortus. AFA shows...
Studying protein interactions in whole organisms is fundamental to understanding development. Here, we combine vivo expressed GFP-tagged proteins with quantitative proteomics identify protein-protein of selected key involved early C. elegans embryogenesis. Co-affinity purification interaction partners for eight bait resulted a pilot map focus on Our network reflects known biology and highly enriched functionally relevant interactions. To demonstrate the utility map, looked new regulators P...
Abstract We report molecular genetic studies of three genes involved in early germ-line proliferation Caenorhabditis elegans that lend unexpected insight into a germ-line/soma functional separation autosomal/X-linked duplicated gene pairs. In screen for proliferation-defective mutants, we identified mutations rpl-11.1 (L11 protein the large ribosomal subunit), pab-1 [a poly(A)-binding protein], and glp-3/eft-3 (an elongation factor 1-α homolog). All are members autosome/X Consistent with...
We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...
The complex cellular events that occur in response to fertilization are essential for mediating the oocyte-to-embryo transition. Here, we describe a comprehensive small-molecule screen focused on identifying compounds affect early embryonic Caenorhabditis elegans. We identify single novel compound disrupts embryogenesis with remarkable stage and species specificity. compound, named C22, primarily impairs eggshell integrity, leading osmotic sensitivity lethality. C22-induced phenotype is...
We present a hierarchical principle for object recognition and its application to automatically classify developmental stages of C. elegans animals from population mixed stages. The machine consists four layers, each composed units upon which evaluation functions output label score, followed by grouping mechanism that resolves ambiguities in the score imposing local consistency constraints. Each layer then outputs groups units, next are derived. Using this principle, builds up successively...
We present DevStaR, an automated computer vision and machine learning system that provides rapid, accurate, quantitative measurements of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study animal development behavior, is particularly amenable to HTP functional genomic analysis due its small size ease cultivation, but lack efficient methods score phenotypes has become a major bottleneck. DevStaR addresses this challenge using...
Abstract Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock crops. Resistance to few anthelmintic drugs is increasing. Here, we report set avocado fatty alcohols/acetates (AFAs) that exhibit nematocidal activity against four veterinary parasitic nematode species: Brugia pahangi , Teladorsagia circumcincta Heligmosomoides polygyrus as well multidrug resistant strain (UGA) Haemonchus contortus....
Stem cells are tightly controlled
The aim of this work is to study a correlation between phenotype and genotype in clinical isolates erythromycin-resistant Streptococcus spp. Among the 25 S. pyogenes, we detected six strains with iMLSB, nine cMLSB two M phenotypes. 14 agalactiae, five seven none an phenotype. Moreover, 8 pyogenes 2 agalactiae showed not matching known ones described literature, defining unknown Upon examination, genetic profiles, erm(A), erm(B) mef(A), did easily correlate specific Our findings highlighted...
Abstract We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...
Abstract LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas Drosophila , help localize Vasa to germ granules facilitate piRNA-mediated transposon silencing. The homologous mammals, TDRD5 TDRD7, are required during spermiogenesis. Until now, both domains Caenorhabditis elegans remained elusive. Here we describe LOTR-1 (D1081.7), which derives its name from LO TUS T udo r domains. Interestingly, docks next P...