A5022703697- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Physiological and biochemical adaptations
- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Evolution and Genetic Dynamics
- thermodynamics and calorimetric analyses
- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Signaling Pathways in Disease
New York University
2021-2025
University of British Columbia
2011-2015
LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas Drosophila, help localize Vasa helicase to germ granules facilitate piRNA-mediated transposon silencing. The homologous mammals, TDRD5 TDRD7, are required during spermiogenesis. Until now, both domains Caenorhabditis elegans remained elusive. Here we describe LOTR-1 (D1081.7), which derives its name from domains. Interestingly, docks next P colocalize with...
Abstract Telomeres are eukaryotic chromosome end structures that guard against sequence loss and aberrant fusions. Telomeric repeat motifs (TRMs), the minimal repeating unit of a telomere, vary from species to species, with some evolutionary clades experiencing rapid divergence. To explore full scope this divergence, many bioinformatic tools have been developed infer novel TRMs using repetitive search on short sequencing reads. However, telomeric remain unidentified in up half libraries...
We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...
The Caenorhabditis elegans gene rec-1 was the first genetic locus identified in metazoa to affect distribution of meiotic crossovers along chromosome. We report that encodes a distant paralog HIM-5, which discovered by whole-genome sequencing and confirmed multiple genome-edited alleles. REC-1 is phosphorylated cyclin-dependent kinase (CDK) vitro, mutation CDK consensus sites compromises crossover vivo. Unexpectedly, rec-1; him-5 double mutants are synthetic-lethal due defect double-strand...
ABSTRACT Telomeres are eukaryotic chromosome end structures that guard against sequence loss and aberrant fusions. Telomeric repeat motifs (TRMs), the minimal repeating unit of a telomere, vary from species to species, with some evolutionary clades experiencing rapid divergence. To explore full scope this divergence, many bioinformatic tools have been developed infer novel TRMs using repetitive search on short sequencing reads. However, telomeric remain unidentified in up half libraries...
Abstract We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...
Abstract LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas Drosophila , help localize Vasa to germ granules facilitate piRNA-mediated transposon silencing. The homologous mammals, TDRD5 TDRD7, are required during spermiogenesis. Until now, both domains Caenorhabditis elegans remained elusive. Here we describe LOTR-1 (D1081.7), which derives its name from LO TUS T udo r domains. Interestingly, docks next P...
Abstract In this study we report a naturally evolved temperature-sensing electrical regulator in the cytochrome c oxidase of Devil Worm, Halicephalobus mephisto. This extremophile metazoan was isolated 1.3 km underground South African goldmine, where it adapted to heat and potentially hypoxia, making its mitochondrial sequence likely target adaptational change. We obtained full genome organism, show through dN/dS analysis statistically robust evidence positive selection H. mephisto subunits....