A5015891855- Genetics, Aging, and Longevity in Model Organisms
- Cellular Mechanics and Interactions
- Diabetes Management and Education
- Photosynthetic Processes and Mechanisms
- DNA and Nucleic Acid Chemistry
- Parasitic Diseases Research and Treatment
- Muscle Physiology and Disorders
- Chronic Disease Management Strategies
- Advanced biosensing and bioanalysis techniques
- Helminth infection and control
- RNA Research and Splicing
- Insect and Arachnid Ecology and Behavior
- Image Processing Techniques and Applications
- Spaceflight effects on biology
- Circadian rhythm and melatonin
- Parasites and Host Interactions
- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Ubiquitin and proteasome pathways
- Biocrusts and Microbial Ecology
- Retinal Development and Disorders
- Reproductive Biology and Fertility
- Traditional and Medicinal Uses of Annonaceae
- RNA regulation and disease
- Cell Image Analysis Techniques
New York University
2019-2025
New York University Abu Dhabi
2017-2025
Lebanese International University
2023
Inserm
2002-2011
Université de Strasbourg
2010-2011
Centre National de la Recherche Scientifique
2009-2011
Institut de génétique et de biologie moléculaire et cellulaire
2009-2010
American University of Beirut Medical Center
2005
Myotubularin is a ubiquitously expressed phosphatase that acts on phosphatidylinositol 3-monophosphate [PI(3)P], lipid implicated in intracellular vesicle trafficking and autophagy. It encoded by the MTM1 gene, which mutated X-linked myotubular myopathy (XLMTM), muscular disorder characterized generalized hypotonia muscle weakness at birth leading to early death of most affected males. The disease was proposed result from an arrest myogenesis, as skeletal patients contains hypotrophic fibers...
Myosin II plays a central role in epithelial morphogenesis; however, its has mainly been examined processes involving single cell type. Here we analyze the structure, spatial requirement and regulation of myosin during C. elegans embryonic elongation, process that involves distinct epidermal cells muscles. We developed novel GFP probes to visualize dynamics actomyosin remodeling, found assembly filaments, but not actin microfilaments, depends on regulatory light chain (MLC-4) essential...
Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock crops. Resistance to few anthelmintic drugs is increasing. Here, we report set avocado fatty alcohols/acetates (AFAs) that exhibit nematocidal activity against four veterinary parasitic nematode species: Brugia pahangi, Teladorsagia circumcincta Heligmosomoides polygyrus, as well multidrug resistant strain (UGA) Haemonchus contortus. AFA shows...
Cucurbit[7]uril-modified iron-oxide nanoparticles (CB[7]NPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system.
We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...
Diabetes mellitus (DM) is a chronic non-communicable endocrine disease that has considerable impact on both the health and quality of life (QoL) patients. This study aimed to investigate sociodemographic factors associated with among Lebanese population DM.A cross-sectional enrolled 125 diabetic patients aged ≥18, was conducted between January June 2021. The validated Arabic version Audit Diabetes-Dependent Quality Life (ADDQoL) questionnaire utilized by all measure (QoL). A logistic...
Diabetes-related distress (DRD) is a psychological syndrome with worsened prognosis in uncontrolled diabetic patients. The current study aimed to assess the factors contributing DRD among Lebanese population using Diabetes Distress Scale (DDS-17) score and its sub-scores. A cross-sectional analysis was conducted between March September 2021 enrolling. 125 from six governorates through an online survey. survey included two parts: first section gathered sociodemographic data socioeconomic...
A microfluidic force assay chip was used to quantify the relative changes in thrashing of<italic>C. elegans</italic>upon exposure various external stimuli.
Abstract High-content screening (HCS) uses microscopy images to generate phenotypic profiles of cell morphological data in high-dimensional feature space. While HCS provides detailed cytological information at single-cell resolution, these complex datasets are usually aggregated into summary statistics that do not leverage patterns biological variability within populations. Here we present a broad-spectrum analysis system measures image-based features from 10 cellular compartments across...
Molecules that bind DNA by intercalating its bases remain among the most potent cancer therapies and antimicrobials due to their interference with DNA-processing proteins. To accelerate discovery of novel drugs, we designed a fluorescence resonance energy transfer (FRET)-based probe reports on intercalation, allowing rapid sensitive screening chemical libraries in high-throughput format. We demonstrate method correctly identifies known intercalators approved drug discover previously...
Abstract Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock crops. Resistance to few anthelmintic drugs is increasing. Here, we report set avocado fatty alcohols/acetates (AFAs) that exhibit nematocidal activity against four veterinary parasitic nematode species: Brugia pahangi , Teladorsagia circumcincta Heligmosomoides polygyrus as well multidrug resistant strain (UGA) Haemonchus contortus....
Abstract We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P condensation, form granules independently of in postembryonic line, balance each other regulating growth localization. MIP-2 contain two LOTUS domains regions homo- heterodimers. They bind anchor Vasa homolog GLH-1 within are jointly required for coalescence MEG-3, GLH-1, PGL proteins. Animals lacking show...