A5050266772- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Psoriasis: Treatment and Pathogenesis
- Stress Responses and Cortisol
- Vitamin D Research Studies
- Healthcare Systems and Technology
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Diverse Legal and Medical Studies
- Corporate Governance and Law
- Anesthesia and Sedative Agents
- Retinal Development and Disorders
- Advanced Proteomics Techniques and Applications
- Cardiac Health and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Psychiatric care and mental health services
- Memory and Neural Mechanisms
- Musculoskeletal Disorders and Rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Circadian rhythm and melatonin
- Poisoning and overdose treatments
- Trauma and Emergency Care Studies
- Corporate Finance and Governance
- Bipolar Disorder and Treatment
Universitätsklinikum Würzburg
2018-2024
Technical University of Munich
2024
University of Regensburg
2018-2022
Ludwig-Maximilians-Universität München
2020
University of Würzburg
2012-2014
Background: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death disability. Behavioral immunological variables influence pathophysiology of both disorders. We therefore determined frequency severity MDD in CVD studied whether without or other somatic influences classical inflammatory biomarkers cardiovascular risk. In addition, we investigated proinflammatory cytokines on antidepressant treatment outcome....
Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in FTLD risk gene progranulin (GRN) a German population of patients with (n = 271) or BPD 237) as compared 574 age-, gender- ethnicity-matched controls. Furthermore, measured plasma levels 26 well 61 Italian 29 matched A significantly decreased allelic frequency minor versus wild-type allele was observed for...
Abstract Major depression is a complex disease and—among others, inflammation appears to play an important role in its pathophysiology. In this study, we investigated broad range of cytokines depressed patients. Plasma levels interleukin (IL)‐12/ IL‐23p40, IL‐15, IL‐16, IL‐17A, IL‐1α, IL‐7, tumor necrosis factorβ and vascular endothelial growth factor were compared 48 patients suffering from major before, after one six weeks antidepressive treatment relation therapy response. Interestingly,...
Abstract Proteome profiling of formalin-fixed paraffin-embedded (FFPE) specimens has gained traction for the analysis cancer tissue discovery molecular biomarkers. However, reports so far focused on single entities, comprised relatively few cases and did not assess long-term performance experimental workflows. Here, we by analyzing 1,220 tumors from six entities processed over course three years. Key findings include need a new normalization method ensuring equal reproducible sample loading...
Inflammatory processes play an important role in the pathophysiology of major depressive disorder (MDD), but their relevance for specific symptoms such as neurocognitive impairment is rarely investigated.In this observational study, we investigated changes leukocyte chemokine (C-C motif) receptor 5 (CCR5) and ligand (CCL5) mRNA levels inflammatory cytokines 60 MDD patients before (PRE) after weeks (W5) antidepressive treatment relation to therapy response alterations cognitive functions by...
As inter-hospital alliances have become increasingly popular in the healthcare sector, it is important to understand challenges and benefits that interaction between representatives of different hospitals entail. A prominent example are certified ‘trauma networks’, which consist 5-30 trauma departments a given region. Trauma networks designed improve care by providing coordinated response injury, developed across USA multiple European countries since 1960s. Their members need interact...
Background Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries. It a multifactorial disease retina modified by environmental/individual (e.g. smoking) and genetic factors. 34 independent genomic loci are associated with risk to develop AMD; an interaction between smoking genetics currently investigated. unclear how knowledge on strong component has entered base practicing ophthalmologists, they inform counsel their patients about it. In this...
The use of selective serotonin reuptake inhibitors (SSRIs) like citalopram in the clinical treatment depressive symptoms children and adolescents has become increasingly common, although application is mostly off-label. increasing number prescriptions not only due to their good efficacy, but also tolerability comparatively low risk cases intoxication. However, there discussion about cardiac safety overdose ingestion citalopram. Here, we report detail on an adolescent with who used 800 mg...
Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other anxiolytics longer application times.The present study compared acute short-term of translocator protein 18 kDa...