A5045630454- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Bone Tissue Engineering Materials
- Neonatal Respiratory Health Research
- Anatomy and Medical Technology
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Bone Metabolism and Diseases
- Dental Implant Techniques and Outcomes
- Congenital Anomalies and Fetal Surgery
- Bone and Dental Protein Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- dental development and anomalies
- Pediatric health and respiratory diseases
- Antimicrobial Peptides and Activities
- Intestinal and Peritoneal Adhesions
- Intestinal Malrotation and Obstruction Disorders
- Asthma and respiratory diseases
- Spine and Intervertebral Disc Pathology
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Periodontal Regeneration and Treatments
- Hernia repair and management
- Medical and Biological Sciences
- Pregnancy and preeclampsia studies
Riga Stradiņš University
2016-2025
Children's Clinical University Hospital
2010-2024
Riga East University Hospital
2017
Pauls Stradiņš Clinical University Hospital
2015
Riga Technical University
2011
Uppsala University
2000
Latvian Academy of Sport Education
1998
Latvian Academy of Sciences
1994
Hidradenitis suppurativa is a chronic skin condition, characterized clinically by painful, recurrent, deep- seated nodules and suppuration, histologically hyper-trophic scarring of apocrine gland bearing sinus tracts. The overall consequence the disease considerable tissue remodelling underlying alterations in innate immunity are poorly understood. aim this study was to evaluate expression human beta-defensin 2, tumour necrosis factor (TNF)-α matrix metalloproteinase-2 lesions patients with...
In naturally occurring bovine mastitis, effects of infection depend on the host inflammatory response, including secreted cytokines. Knowledge about and regulatory cytokines in milk cells free-stall barn dairy cows mastitis is lacking as most studies focus induced mastitis. Hereby, aim study was to determine with subclinical clinical The following examinations samples were performed: differential counting somatic (SCC), bacteriological examination, immunocytochemical analysis. Mean SCC...
Background: Numerous studies have shown the presence of multiple defence factors in placental tissue, although their role is partially understood; therefore, aim this study was to evaluate expression nuclear factor-kappa B (NF-κB); human beta-defensin 2, 3, and 4 (HBD-2,3,4); cathelicidine (LL-37); heat shock protein 60 (HSP60); interleukin 10 (IL-10) dissimilar gestational week tissue display correlations between immunoreactive cells. Methods: A total 15 samples were acquired from mothers...
Background: The rising rates of gallstones and cholecystectomy in pediatric populations underscore the increasing concern regarding chronic cholecystitis. However, morphopathogenesis calculous cholecystitis is still not well understood. This study aimed to determine expression distribution immunomodulatory factors interleukin-12 (IL-12), interleukin-13 (IL-13), interleukin-1β (IL-1β), sonic hedgehog protein (SHH), nuclear factor NF-kappa-B p65 subunit (NFkBp65), heat shock 60 (HSP60)...
Background. Cleft lip palate is one of the most common craniofacial birth defects in humans. Multiple defense factors have been described to possible involvement failure palatal shelve elevation, migration and fusion, importantly, role chronic inflammation. A widespread presence Gal-10 different local inflammatory processes has discussed before, however, knowledge its tissue inflammation postnatal cleft regeneration scant. This study focuses on detection appearance a cleft-affected facial...
Educational institutions in several countries state that the education sector should be modernized to ensure a contemporary, individualized, and more open learning process by introducing developing advance digital solutions tools. Visualization along with 3D printing have already found their implementation different medical fields Pauls Stradiņš Clinical University Hospital, Rīga University, where models are being used for prosthetic manufacturing, surgery planning, simulation of procedures,...
Background and Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) presently remains a difficult disease to manage. Antimicrobial defense proteins are important factors that could help characterize the role of microorganisms in CRSwNP pathogenesis, as concept microbial dysbiosis CRS is still being considered. Our aim investigate complex appearance, relative distribution interlinks human β defensin 2 (HBD-2), 3 (HBD-3), 4 (HBD-4), cathelicidin LL 37 (LL 37) chronic (CRSwNP)-affected...
The integration of artificial intelligence (AI), particularly through machine learning (ML) and deep (DL) algorithms, marks a transformative progression in medical imaging diagnostics. This technical note elucidates novel methodology for semantic segmentation the vertebral column CT scans, exemplified by dataset 250 patients from Riga East Clinical University Hospital. Our approach centers on accurate identification labeling individual vertebrae, ranging C1 to sacrum–coccyx complex. Patient...
Background and objectives: Cleft lip palate takes the second place among all anomalies. The complex appearance of cytokines proliferation markers has still not been clarified despite their possible crucial role in cleft tissue. Therefore, aim work was detection pro- anti-inflammatory marker Ki67, inter-correlations affected (CAL). Materials Methods: material obtained from 16 children aged before primary dentition during plastic surgery. Control 7 non-CAL oral Tissues were stained for IL-1,...
<h3>Abstract</h3> Demographers were among the first to emphasize importance of age in explaining spread and impact on mortality COVID-19. Yet, relationship between COVID-19 is not fully understood. This study aims answer following questions: Do deaths follow Gompertz force mortality? How does compare with other major causes death? Does this vary countries? Using US vital Statistics, doubling time compared 68 cause death categories. fatality similarly across 33 countries using COVerAGE-DB, a...
Background: Strontium (Sr) enriched biomaterials have been used to improve bone regeneration in vivo. However, most studies provide only two experimental groups. The aim of our study was compare eleven different sample groups from osteoporotic and healthy rabbits’ femoral neck, as it is the frequent fracture humans. Methods: Osteoporotic defects were filled with hydroxyapatite 30% (HA) tricalcium phosphate 70% (TCP), 5% Sr-enriched HA30/TCP70, HA70/TCP30, or Sr-HA70/TCP30 granules compared...
The choice of technique for the creation a 3D digital human bone model from natural specimens has critical impact on final result and usability obtained model. cornerstone factor in modeling is number faces polygon mesh, along with topological accuracy, as well resolution level detail texture map. Three different techniques (3D scanning, photogrammetry, micro-computed tomography) have been used to create zygomatic bone. As implementation use models can be divided into three main...
Background and Objectives. The aim of this study was to compare the distribution proliferation markers (Ki-67, NF-κβ), tissue-remodeling factors (MMP-2, MMP-9, TIMP-2, TIMP-4), vascular endothelial growth factor (VEGF), interleukins (IL-1 IL-10), human beta defensins (HβD-2 HβD-4) Sonic hedgehog gene protein in cholesteatoma control skin. Methods. Nineteen patient tissues seven skin materials from cadavers were included stained immunohistochemically. Results. Statistically discernible...
Orofacial clefts have been associated with specific cleft candidate genes which encode regulatory proteins required for orofacial region development. Cleft involved the morphopathogenesis process, but their exact interactions and roles are relatively unclear in human tissue. This study evaluates presence correlations of Sonic Hedgehog (SHH), SRY-Box Transcription Factor 3 (SOX3), Wingless-type Family Member 3A (WNT3A) 9B (WNT9B) protein containing cells different Non-syndromic cleft-affected...
Abstract The aim of the study was to determine effect Jerusalem artichoke and probiotics on defence activity intestinal cells weaning pigs. One hundred eighty piglets (7 weeks old) were fed with basal feed supplemented artichoke, Lactobacillus reuteri Pediococcus pentosaceus. After 5 weeks, slaughtered gastrointestinal contents intestine samples taken for analysis. Results demonstrated that in pigs diet both (5% diet) (T3 group) had less (P<0.05) faecal Enterobacteriaceae microorganisms...
Background and Objectives: Intercellular signaling networks with high complexity cause a spectrum of mechanisms achieving chronic obstructive pulmonary disease (COPD) that still question many uncertainties. Materials Methods: Immunoreactive cells in bronchial tissue obtained from 40 COPD patients 49 healthy control subjects were detected by biotin-streptavidin immunohistochemistry method for the following markers IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, TNF-α, MMP-2, TIMP-2, TGF-β1,...