A5067028236- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Liver Diseases and Immunity
- Folate and B Vitamins Research
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Blood properties and coagulation
- Pharmacogenetics and Drug Metabolism
- Renal cell carcinoma treatment
- Voice and Speech Disorders
- Sarcoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Systemic Sclerosis and Related Diseases
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
- Colorectal Cancer Treatments and Studies
- Muscle metabolism and nutrition
- Gastrointestinal Tumor Research and Treatment
- Healthcare and Venom Research
Siriraj Hospital
2009-2024
Mahidol University
2009-2024
VA Connecticut Healthcare System
2005
Connecticut Health Foundation
2005
Yale University
2005
Yale New Haven Hospital
2005
Bassett Healthcare Network
2003
Previously, we have validated a 4-drug phenotyping cocktail, the "Cooperstown cocktail," using caffeine (cytochrome p450 [CYP] 1A2, N-acetyltransferase-2 [NAT2], and xanthine oxidase [XO]), dextromethorphan (CYP2D6), omeprazole (CYP2C19), intravenous midazolam (hepatic CYP3A). Data suggest that warfarin can be used as safe accurate biomarker for CYP2C9, if is administered with vitamin K, pharmacodynamic effect ablated. Twelve subjects received Cooperstown plus both sets of biomarkers...
Physical inactivity and sarcopenia are two important predictors associated with increased morbidity mortality in patients cirrhosis. At present, the benefit of a home-based exercise training program is not well established cirrhotic patients. The main objective this study was to evaluate effect 12-week on aerobic capacity patients.This randomized controlled study. Patients compensated cirrhosis were by block 4 concealed allocation (n = 20) or control 20). Both groups received protein...
To investigate the performance of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for predicting severe acute pancreatitis (AP).Fifty patients with AP were prospectively enrolled. Erythrocyte CRP measured at admission every 12 hours 48 after admission.The patients' mean age was 50 ± 2.2 years, 64% male, 30% developed AP. Patients had higher levels ESR (77 4.7 vs 4.8 mm/h; P = 0.002) (218 30.7 97 12.1 mg/L; <0.001) 36 compared those mild rates 60 mm/h or greater predict a...
Background Patients with acute-on-chronic liver failure (ACLF) precipitated by hepatic injury and extrahepatic insults had distinct clinical phenotypes, prognosis. This study aimed to validate prognostic models for ACLF explore their discriminative abilities in population categorized the etiologies of precipitating events. Methods collected data from 343 consecutive cirrhotic patients hospitalized diagnosis according EASL-CLIF-Consortium definition. The discrimination at onset were tested...
Hepatitis E virus (HEV) is a common cause of acute hepatitis infections. Our previous 3-year study at two large Thai hospitals established an occurrence 4-5% HEV infections from swine genotype 3 in suspected patients, with the high incidence older adults. This was serosurvey to determine prevalence among We obtained sera 630 healthy blood donors median age 38 (18-64) years who attended Red Cross transfusion units throughout Thailand. The were domiciled 16 provinces northern (n = 159),...
Summary. Hepatitis C virus (HCV) infection is more frequent in veterans than nonveterans. Up to 85% of HCV‐infected have psychiatric and/or substance use (SU) co‐morbidities which, prior the 2002 NIH Consensus Conference, were considered relative contraindications antiviral therapy, assuming a poor adherence. With objective evaluating validity this assumption, we compared eligibility, completion and response therapy with without these comorbidities. Veterans who anti‐HCV‐positive had been...
Background: International guidelines for hepatitis B infection (HBV) recommend initiating antiviral treatment based on viral replication with inflammation or fibrosis. HBV loads and liver fibrosis measurements are not widely available in resource-limited countries. Aim: To develop a novel scoring system the initiation of HBV-infected patients. Methods: We examined 602 420 treatment-naïve, mono-infected patients derivation validation cohorts. performed regression analysis to identify...
Aim To evaluate the utility of combination alanine aminotransferase (ALT) course, hepatitis B virus (HBV) DNA level, and liver stiffness measurement (LSM) for determining significant disease in e antigen (HBeAg)‐negative patients. Methods Three hundred ninety nine consecutive HBeAg‐negative patients with HBV >2000 IU/mL documented serial measurements ALT were enrolled to undergo LSM followed by biopsy. Results Using <40 IU/L as a normal value, 142 had persistently (PNALT), whereas 257...
Acute-on-chronic liver failure (ACLF) leads to multi-organ related high mortality rates. This study aimed gather epidemiological data and validate a scoring system predict in ACLF.This retrospective cohort collected from multicenter tertiary care hospitals Thailand. A total of 638 hospitalized patients (acute decompensated disease [ADLD], 292 patients; ACLF, 346 patients) January 2019 June 2020 were enrolled this study. We compared the rate at days 30 90 between with ADLD ACLF. Areas under...
Background and AimsMetabolic dysfunction-associated fatty liver disease (MAFLD) is prevalent in patients with chronic hepatitis B (CHB). The effect of the histologic MAFLD phenotype on long-term CHB outcomes unknown. We performed a longitudinal study to determine prognostic relevance biopsy-proven hepatic steatosis steatohepatitis for patients.
Cirrhosis patients with worsening of the liver function are defined as acute decompensation (AD) and those who develop extrahepatic organ failure acute-on-chronic (ACLF). Both AD ACLF have an extremely poor prognosis. However, information regarding prognostic predictors is still lacking in Asian populations. We aimed to identify factors for 30-day 90-day mortality cirrhosis or without ACLF.We included 9 tertiary hospitals from Thailand a retrospective observational study enrolling...
The utility of serial procalcitonin (PCT) measurements in cirrhotic patients with systemic inflammatory response syndrome (SIRS) is not well understood. This study aimed to assess the effectiveness PCT for diagnosing bacterial infections and predicting 30-day mortality this population. We prospectively studied 120 SIRS, 64.2% whom had infections. Serial levels were measured within first 72 hours admission. Patients significantly higher at admission, 24 hours, compared those without values...
Abstract Hepatitis E virus (HEV) is a causative agent of acute viral hepatitis globally. Evolutionary phylogeny classifies the HEV into eight genotypes that correlate with transmission. Only four have been proven to be responsible for transmission in humans. However, there has no report on genomics and genotyping Thailand during past ten years. Here, we identified genotype distributions Thai isolates sequenced two genomes. We screened 18 from Siriraj Hospital Bangkok, 2014–2016. The genomes...