A5046819543- Neonatal Health and Biochemistry
- Methemoglobinemia and Tumor Lysis Syndrome
- Proteins in Food Systems
- Hemoglobinopathies and Related Disorders
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Phytase and its Applications
- Advanced Drug Delivery Systems
- Mosquito-borne diseases and control
- Enzyme Production and Characterization
- Metabolism and Genetic Disorders
- Malaria Research and Control
- biodegradable polymer synthesis and properties
- Polymer Nanocomposites and Properties
- Advanced biosensing and bioanalysis techniques
- Peroxisome Proliferator-Activated Receptors
- Infant Nutrition and Health
- Biochemical and Molecular Research
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Biomedical Research and Pathophysiology
- Heme Oxygenase-1 and Carbon Monoxide
- Alzheimer's disease research and treatments
Program for Appropriate Technology in Health
2014-2024
Seattle University
2024
Jadavpur University
1988-2021
University of South Florida
2020
Tripura University
2019
University of Washington
2001-2011
University of Washington Medical Center
2006-2010
Directorate of Medicinal and Aromatic Plants Research
2010
Central Leather Research Institute
2008
Medical College and Hospital, Kolkata
2004
Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and displays antioxidant, anti-inflammatory, immunomodulatory actions that contribute to its hepatoprotective effects. In the current study, we evaluated of seven major flavonolignans one flavonoid comprise silymarin. Activities tested included inhibition of: HCV cell culture infection, NS5B polymerase activity, TNF-α-induced NF-κB transcription, virus-induced oxidative stress, T-cell proliferation. All...
Hepatitis C virus (HCV)-induced chronic inflammation may induce oxidative stress which could compromise the repair of damaged DNA, rendering cells more susceptible to spontaneous or mutagen-induced alterations, underlying cause liver cirrhosis and hepatocellular carcinoma. In current study we examined induction reactive oxygen species (ROS) resulting from HCV infection evaluated its effect on host DNA damage machinery.HCV infected human hepatoma were analyzed determine (i) ROS, (ii) 8-oxoG...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common genetic blood condition, can result in kernicterus at birth, and later life as severe hemolysis on exposure to certain infections, foods, drugs. The unavailability of point-of-care tests for G6PD deficiency is barrier routine curative treatment Plasmodium vivax malaria with 8-aminoquinolines, such primaquine. Two quantitative reference (Trinity Biotech, Bray, Ireland Pointe Scientific, Canton, MI; Cat No. G7583) the STANDARD™ test...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency, prevalent in many malaria-endemic countries. G6PD-deficient individuals are susceptible to hemolysis during oxidative stress, which can occur from exposure certain medications, including 8-aminoquinolines used treat Plasmodium vivax malaria. Accordingly, access point-of-care (POC) G6PD testing Brazil critical for safe treatment of P. malaria.This study evaluated the performance semi-quantitative, POC STANDARD...
The introduction of novel short course treatment regimens for the radical cure Plasmodium vivax requires reliable point-of-care diagnosis that can identify glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. While males be identified using a qualitative diagnostic test, genetic make-up females quantitative measurement. SD Biosensor (Republic Korea) has developed handheld G6PD (STANDARD test), approximately 90% accuracy in field studies identifying individuals with intermediate or...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in human population affecting an estimated 8% of world population, especially those living areas past and present malaria endemicity. Decreased G6PD enzymatic activity associated with drug-induced hemolysis increased risk severe neonatal hyperbilirubinemia leading to brain damage. The gene on X chromosome therefore mutations cause hemizygote males homozygote females while majority heterozygous have...
Bovine beta lactoglobulin (β-lg), the major whey protein, has a great affinity for wide range of organic compounds like fatty acids, retinol<italic>etc.</italic>
Abstract Polyesteramide polyols have been synthesized by melt condenstion using a mixture of alkanolamines, polyethylene glycols, and dicarboxylic acids/anhydrieds, the behavior or resin samples as interfacrial agents in unidirectional well random composites jute/epoxy jute/polyester has evaluated. Mechanical properties these composties with without interfacial determined along effect water uptake on such properties. The incorporation polyesteramide polyol (PEAP) resins interfacila found to...
Since 2005, Ethiopia has aggressively scaled up malaria prevention and case management. As a result, the number of cases deaths significantly declined. In order to track progress towards elimination in Amhara Region, coverage control tools current transmission need be documented.A cross-sectional household survey oversampling children under 5 years age was conducted during dry season 2013. A bivalent rapid diagnostic test (RDT) detecting both Plasmodium falciparum vivax serology assays using...
Introduction Screening for G6PD deficiency can inform disease management including malaria. Treatment with the antimalarial drugs primaquine and tafenoquine be guided by point-of-care testing deficiency. Methods findings Data from similar clinical studies evaluating performance of STANDARD Test (SD Biosensor, South Korea) conducted in Bangladesh, Brazil, Ethiopia, India, Thailand, United Kingdom, States were pooled. was assessed a retrospective analysis on capillary venous specimens. All...
The role of viral factors in the pathogenesis chronic hepatitis C is unknown. objective present study was to characterize markers virus (HCV) infection and replication liver biopsy specimens obtained from 65 genotype 1-infected subjects, including 31 who were coinfected with human immunodeficiency (HIV), analyze associations between intrahepatic disease severity. percentages cells harboring HCV genomes (%G) replicative-intermediate RNAs (%RI) evaluated using strand-specific situ...
Abstract A systematic study of the process variables for polyester composites based on different natural fibers like jute, sisal, ramie, and pineapple has been made with a view to determine most suitable processing conditions such composites. Effect polyesteramide polyol (PEAP) as interfacial agent in also discussed. Fracture modes jute/polyester (JP) composite sample having fiber volume fractions have examined by scanning electron microscope (SEM). surfaces untreated PEAP‐treated JP samples...
Point-of-care glucose-6-phosphate dehydrogenase (G6PD) testing has the potential to make use of radical treatment for vivax malaria safer and more effective. Widespread G6PD tests as part case management been limited, in due concerns regarding product usability, user training, supervision. This study seeks assess how well end users can understand Standard™ Test (SD Biosensor, Suwon, South Korea) workflow, result output, label after training. will ultimately help inform test registration...
Certain clinical indications and treatments such as the use of rasburicase in cancer therapy 8-aminoquinolines for Plasmodium vivax malaria treatment would benefit from a point-of-care test glucose-6-phosphate dehydrogenase (G6PD) deficiency. Three studies were conducted to evaluate performance one test: STANDARD™ G6PD Test (SD BIOSENSOR, South Korea). First, biological interference on was evaluated specimens with common blood disorders, including high white cell (WBC) counts. Second,...
Cationic dyeable polyester (CDPET) yarns were produced through melt blending of cationic chips having 2 mol % sodium salt dimethyl ester 5-sulfoisophthalic acid (DMS salt) and normal in different proportions to obtain varying amount comonomer the fiber. These partially oriented CDPET texturized under identical conditions on a draw-texturing machine. It has been observed that with increase content CDPET, dye uptake increases, but tensile crimp properties are adversely affected. The...
This work reports selective methionine oxidation of β-lactoglobulin by <italic>t</italic>BHP reduces its thermal stability and enhances fibrillation propensity.
Abstract HIV particles are detected extracellularly in lymphoid tissues, a major reservoir of the virus. We previously reported that polymerized form fibronectin (FN), superfibronectin (sFN), as well fragment FN, III1-C, enhanced infection primary CD4+ T cells by HIV-1IIIB. now show sFN enhances both R5 and X4 strains HIV-1. Using pseudotyped with different envelope glycoproteins (gp120) HOS transfected various chemokine receptors alone or combination CD4 molecule, we sFN-mediated...