A5018749642- Nonlinear Dynamics and Pattern Formation
- Theoretical and Computational Physics
- Fluid Dynamics and Vibration Analysis
- Spectroscopy and Quantum Chemical Studies
- Reproductive tract infections research
- Fluid Dynamics and Turbulent Flows
- Neural Networks and Applications
- Photoreceptor and optogenetics research
- Material Dynamics and Properties
- COVID-19 Clinical Research Studies
- Complex Systems and Time Series Analysis
- Reproductive System and Pregnancy
- Neural dynamics and brain function
- NMR spectroscopy and applications
- Marine Toxins and Detection Methods
- Stochastic processes and statistical mechanics
- Characterization and Applications of Magnetic Nanoparticles
- SARS-CoV-2 and COVID-19 Research
- Pickering emulsions and particle stabilization
- Advanced Chemical Sensor Technologies
- Cervical Cancer and HPV Research
- Diet and metabolism studies
- Pelvic floor disorders treatments
- Granular flow and fluidized beds
- Computational Drug Discovery Methods
Harvard University Press
2025
Harvard University
2022-2024
Inspire
2023-2024
Brandeis University
2008-2021
Semmelweis University
2017
Széchenyi István University
2015
Eötvös Loránd University
2000-2014
Universität Hamburg
2008
University of Pittsburgh
2000-2001
Forschungszentrum Jülich
1996
Abstract Background A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological obstetric health, while presence diverse obligate or facultative anaerobic bacteria a paucity species, similar to communities found bacterial vaginosis (BV), considered non-optimal adverse health outcomes. Various therapeutic strategies are being explored modulate composition microbiome; however, there no human model that faithfully reproduces...
The time evolution and geometry of rough interfaces observed in experiments on immiscible displacement viscous fluids porous media are analysed using the concepts dynamic scaling self-affine fractal geometry. authors find that development interface is governed by they have determined corresponding surface exponents alpha beta . values calculated for experimental patterns different from those obtained a variety two-dimensional models marginally stable interfaces.
Abstract Modulation of the cervix by steroid hormones and commensal microbiome play a central role in health female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate human cervical epithelial-stromal interface with functional epithelial barrier production mucus biochemical hormone-responsive properties similar to living cervix. When Cervix Chips are populated optimal healthy versus dysbiotic microbial communities (dominated Lactobacillus crispatus...
Finger on the pulse: In a system of two pulse-coupled Belousov–Zhabotinsky oscillators, introducing time delay or increasing coupling strength brings about novel dynamic features (see picture, oscillators are shown in different colors), such as reversal roles excitatory and inhibitory fast anti-phase oscillation. These not observed diffusively coupled systems, shed light how pulse occurs at synapses.
Experiments were carried out using a tensile testing machine to study the morphology of rupture lines in paper. Constant velocity strain was applied until breaking process separated sample into two pieces. The resulting quasi one-dimensional patterns show scaling correlations usually over orders magnitudes. measured values Hurst exponent ζ are range 0.63 < 0.72. relevance models statistical physics interpretation results is discussed.
<title>Abstract</title> Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well increased inflammation, fibrosis, cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by patient-derived colon epithelial cells interfaced matched fibroblasts cultured under flow. Use of heterotypic tissue recombinants revealed...
In vitro selection is typically limited to discovery of peptides, proteins and nucleic acids. Given the importance carbohydrate-protein interactions in diverse areas biology including cell adhesion/recognition, immunoregulation host-pathogen interactions, directed-evolution-based methods for potent glycoligands are greatly needed. We have previously reported a method glycopeptides that combines mRNA display, alkynyl amino acid incorporation, CuAAC "click" glycosylation. Herein, we describe...
The fluctuations of the advancing interface observed in experiments on two-phase fluid flow porous media are investigated using several evaluation techniques. We find that amplitudes \ensuremath{\eta} these distributed according to a power law form P(\ensuremath{\eta})\ensuremath{\sim}${\mathrm{\ensuremath{\eta}}}^{\mathrm{\ensuremath{-}}(\mathrm{\ensuremath{\mu}}+1)}$, with \ensuremath{\mu}\ensuremath{\approxeq}2.7. Our results together recent model anomalous roughening suggest plausible...
To better understand the temporal behavior of a roughening meniscus driven by capillary forces during imbibition viscous fluid in porous media, we measure height-height autocorrelation function C(t) using constant driving force. We find C(t)\ensuremath{\sim}${\mathit{t}}^{\mathrm{\ensuremath{\beta}}}$, with \ensuremath{\beta}=0.56\ifmmode\pm\else\textpm\fi{}0.03, and provide experimental evidence for force independent scaling propagating wetting front presence quenched noise. interpret value...
We study viscous fingering in the radial Hele-Shaw cell with a set of parallel grooves on one plates order to obtain morphological phase diagram system imposed uniaxial anisotropy. Varying pressure air injected into glycerin and distance between plates, rich variety phases can be obtained corresponding all possible combinations stable or splitting tips directions perpendicular grooves. demonstrate that effective anisotropy governing stability is result complex interplay local driving force.
A Comment on the Letter by Rubio et al., Phys. Rev. Lett. 63, 1685 (1989).Received 13 December 1989DOI:https://doi.org/10.1103/PhysRevLett.65.1388©1990 American Physical Society
All pH-oscillators reported to date function only under open (flow reactor) conditions. We describe an approach generating pH-oscillations in a closed system by starting from pH-oscillator, finding semibatch conditions which it oscillates with inflow of single reactant otherwise reactor containing the remaining components, and replacing this layer silica gel impregnated key reactant. present data showing successful application technique BrO(3)(-)-Mn(2+)-SO(3)(2-),...
BackgroundSulfadoxine-pyrimethamine (SP) antimalarial therapy has been suggested to potentially increase the birth weight of infants in pregnant women sub-Saharan Africa, independently malarial infection. Here, we utilized female intestinal organoid-derived cells cultured within microfluidic Organ Chips investigate whether SP could directly impact function and thereby improve absorption essential fats nutrients crucial for fetal growth.MethodsUsing a human organ-on-a-chip model, replicated...
Abstract The ongoing COVID-19 pandemic has claimed more than 6 million lives and continues to test the world economy healthcare systems. To combat this pandemic, biological research community shifted efforts development of medical countermeasures, including vaccines therapeutics. However, date, only small molecules approved for treatment in United States are nucleoside analogue Remdesivir protease inhibitor Paxlovid, though multiple compounds have received Emergency Use Authorization many...
Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly pandemic scenario. In response to the challenge identify treatment options for COVID-19, several studies reported that statins, as class, reduce mortality these patients. However, it is unknown if different statins exhibit consistent function or may have varying benefit. A Bayesian network...
Bioconvection occurs when upward swimming micro-organisms generate gravitational energy that initiates and maintains dissipative movement of the water in which they swim. Advection, motion organisms relative to fluid, patchiness concentration drives shapes geometry rate convection. This paper presents a method for quantitatively analyzing development self-organization, numerical estimates connect interpret theory experiment. While oxygen consuming, oxgen-gradient-guided bacteria Bacillus...
A host of asymptotically stable, temporally periodic patterns are found when chemical oscillators pulse coupled,<italic>e.g.</italic>, the 1 : 2 and D–N type shown here.
We present a numerical study on the dynamics of imbibition fronts in porous media using pipe network model. This model quantitatively reproduces anomalous scaling behavior found experiments [Phys. Rev. E 52, 5166 (1995)]. Using simple arguments, we derive new identity among exponents agreement with experimental results.
We performed experiments and computer simulations in order to investigate whether the rain drops on a window pane are ``self-organized critical state,'' as proposed by Bak, Tang, Wiesenfeld [Phys. Rev. Lett. 59, 381 (1987); Phys. A 38, 364 (1988); J. Stat. 51, 797 (1988)]; Tang Bak 60, 2347 (1988)]. In contrast expected behavior, we found that coverage fluctuations exhibit an ${f}^{\mathrm{\ensuremath{-}}2}$ power spectrum, characteristic distribution functions of elementary events have no...
Security Patterns - the adaption of Design by Gamma et al. to security have not quite met expectations since Yoder and Barcalow pioneered field. The two main reasons for this are lack formalisation fact that often permeates all parts a software, which is hard encapsulate in single pattern.
To study the effects of a driving force on interfacial-pattern formation, we introduce novel experimental system, radial Hele-Shaw cell with nitrogen injected into smectic liquid crystal. In absence initial alignment molecules cross-over can be observed: effective fractal dimension pattern changes from value D ≈ 1.6 (low pressures) to 2 (high pressures). If an external magnetic field is applied achieve uniaxial ordering, dramatic change in direction easy growth takes place as function...
ABSTRACT Modulation of mucus production by the human endo– and ecto-cervical epithelium steroid hormones associated interactions with commensal microbiome play a central role in physiology pathophysiology female reproductive tract. However, most our knowledge about these is based on results from animal studies or vitro models that fail to faithfully mimic mucosal environment cervix. Here we describe microfluidic organ-on-a-chip (Organ Chip) cervical mucosa recreate epithelial-stromal...
We report experimental results for the behavior of slow-combustion fronts in presence a columnar defect with enhanced or reduced driving, and compare them those mean-field theory. also simulation an analogous problem driven flow particles hard-core repulsion (ASEP) single bond different hopping probability. The difference shape front profiles vs driving clearly demonstrates existence Kardar-Parisi-Zhang-type nonlinear term effective evolution equation fronts. find that display faceted form...