- Plant Stress Responses and Tolerance
- Heat shock proteins research
- Photosynthetic Processes and Mechanisms
- Plant biochemistry and biosynthesis
- Plant responses to water stress
- Plant tissue culture and regeneration
- Plant Genetic and Mutation Studies
- Streptococcal Infections and Treatments
- GABA and Rice Research
- Plant Molecular Biology Research
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Rice Cultivation and Yield Improvement
- Infective Endocarditis Diagnosis and Management
- Genetic and Environmental Crop Studies
- Seed Germination and Physiology
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Inflammasome and immune disorders
- Transgenic Plants and Applications
- Cardiac Valve Diseases and Treatments
- Vascular anomalies and interventions
- Plant responses to elevated CO2
- Plant-Microbe Interactions and Immunity
- Cardiac tumors and thrombi
Harvard University
2025
Birla Institute of Technology and Science, Pilani
2025
University of Delhi
2013-2023
B.P. Koirala Institute of Health Sciences
2006-2016
Defence Institute of Bio-Energy Research
2015
Post Graduate Institute of Medical Education and Research
2000-2009
Apollo Hospitals
2009
The Alfred Hospital
2007
Institute of Post Graduate Medical Education and Research
2005
University of California, Davis
2004
Abstract Background Heat shock proteins (Hsps) constitute an important component in the heat response of all living systems. Among various plant Hsps (i.e. Hsp100, Hsp90, Hsp70 and Hsp20), Hsp20 or small (sHsps) are expressed maximal amounts under high temperature stress. The characteristic feature sHsps is presence α-crystallin domain (ACD) at C-terminus. cooperate with Hsp100/Hsp70 co-chaperones ATP-dependent manner preventing aggregation cellular their subsequent refolding. Database...
Drought stress is one of the major abiotic stresses that are a threat to crop production worldwide. impairs plants growth and yield. Therefore, aim present experiment was select tolerant genotype/s on basis moprpho-physiological biochemical characteristics 10 Vicia faba genotypes (Zafar 1, Zafar 2, Shebam, Makamora, Espan, Giza Blanka, 3, C4, C5 G853) under drought stress. We studied effect different levels i.e., (i) normal irrigation (ii) mild (iii) moderate stress, (iv) severe plant height...
Plants, like animals, are obligate aerobes, but due to their inability move, have evolved adaptation mechanisms that enable them survive short periods of low oxygen supply, such as those occurring after heavy rain or flooding. Crop plants often grown on soils subject waterlogging and many sensitive the root zone. The combination unfavourable weather conditions suboptimal soil irrigation techniques can result in severe yield losses. molecular basis transient has not been completely...
Heat stress results in misfolding and aggregation of cellular proteins. shock proteins (Hsp) enable the cells to maintain proper folding proteins, both unstressed as well stressed conditions. Hsp70 genes encode for a group highly conserved chaperone across living systems encompassing bacteria, plants, animals. In network, family interconnect other chaperones play dominant role various cell processes. To assess functionality rice genes, genome database was analyzed. Rice contains 32 genes....
With recent advancements in DNA‐chip technology, requisite software development and support progress related aspects of plant molecular biology, it is now possible to comprehensively analyze the expression complete genomes. Global transcript profiling shows that plants, salt‐stress response involves simultaneous up downregulation a large number genes. This analysis further suggests apart from transcripts govern synthesis osmolytes ion transporters, two candidate systems have attracted much...
Genome wide transcriptional changes by cold stress, heat stress and oxidative in rice seedlings were analyzed. Heat resulted predominant transcripts of shock protein transcription factor genes, as well genes associated with synthesis scavengers reactive oxygen species that control the level sugars, metabolites auxins. Cold treatment caused differential expression various factors including desiccation response element binding proteins different kinases. Transcripts are part calcium signaling,...
Heat stress (HS) is the major constraint to crop productivity worldwide. The objective of present experiment was select tolerant and sensitive genotype(s) on basis morpho-physiological biochemical characteristics ten Vicia faba genotypes. These genotypes were as follows: Zafar 1, 2, Shebam Makamora, Espan, Giza Blanka, 3, C4, C5 G853. experimental work undertaken study effects different levels temperature (control, mild, modest) plant height (PH) plant(-1), fresh weight (FW) dry (DW) area...
The concept that heat stress (HS) causes a large accumulation of reactive oxygen species (ROS) is widely accepted. However, the intracellular compartmentation ROS has been poorly characterized. We therefore used redox-sensitive green fluorescent protein (roGFP2) to provide compartment-specific information on heat-induced redox changes nuclei and cytosol Arabidopsis leaf epidermal stomatal guard cells. show HS increase in degree oxidation both compartments, causing shifts glutathione...
Low O2 stress to a varied extent affects almost all the organisms either throughout or at specific stages in their life cycle. Plants experience this generally field conditions when flooding, submergence waterlogging of roots/plants occurs. availability during flooding results enormous yield losses variety crops. There is overwhelming evidence indicating that adaptations low involves changes molecular, biochemical, physiological, genetical and anatomical/morphological attributes plants. Most...
ClpB-cytoplasmic (ClpB-cyt)/Hsp100 is an important chaperone protein in rice. Cellular expression of OsClpB-cyt transcript governed by heat stress, metal and developmental cues. Transgenic rice plants produced with 2 kb promoter driving Gus reporter gene showed heat- metal-regulated vegetative tissues constitutive calli, flowering tissues, embryonal half seeds. Rice seedlings regenerated fragment deletion its canonical shock element sequence (HSE(-273 to -280)) not only inducibility...
ClpB-cyt/HSP100 protein acts as chaperone, mediating disaggregation of denatured proteins. Previous studies have shown that gene belongs to the group class I Clp ATPase proteins and transcript is regulated by heat stress developmental cues.Nine ORFs were noted constitute rice ATPases in following manner: 3 ClpB (ClpB-cyt, Os05g44340; ClpB-m, Os02g08490; ClpB-c, Os03g31300), 4 ClpC (ClpC1, Os04g32560; ClpC2, Os12g12580; ClpC3, Os11g16590; ClpC4, Os11g16770) 2 ClpD (ClpD1, Os02g32520; ClpD2,...