A5036389147- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Aortic aneurysm repair treatments
- Prostate Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Congenital Heart Disease Studies
- Radiation Therapy and Dosimetry
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- Gastrointestinal Tumor Research and Treatment
- Management of metastatic bone disease
- Occupational and environmental lung diseases
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Liver Disease Diagnosis and Treatment
- Radiation Dose and Imaging
- Cardiac Valve Diseases and Treatments
- Pituitary Gland Disorders and Treatments
Keio University
2013-2024
Keio University Hospital
2004-2021
National Institute of Technology and Evaluation
2012
Tokyo Medical Center
2004-2006
Weatherford College
2006
Sapporo Medical University
1997-2004
Tokyo Metropolitan Hiroo Hospital
2004
University of Miami
2001
University of Illinois Chicago
2001
Hakodate National Hospital
1995
Radiation Injury After Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CTToshiaki Takeda1, Atsuya Etsuo Kunieda1 2, Akitoshi Ishizaka3, Kazuhiko Takemasa1, Kyoko Shimada1, Seika Yamamoto1, Naoyuki Shigematsu2, Osamu Kawaguchi2, Jun-ichi Fukada1 Toshio Ohashi2, Sachio Kuribayashi2 and Atsushi Kubo2Audio Available | Share
Polyphosphate accumulating organisms (PAOs) belong mostly to Proteobacteria and Actinobacteria are quite divergent. Under aerobic conditions, they accumulate intracellular polyphosphate (polyP), while typically synthesize polyhydroxyalkanoates (PHAs) under anaerobic conditions. Many ecological, physiological, genomic analyses have been performed with proteobacterial PAOs, but few actinobacterial PAOs. In this study, the whole genome sequence of an PAO, Microlunatus phosphovorus NM-1T (NBRC...
Under hypoxic conditions, nitroimidazoles can replace oxygen as electron acceptors, thereby enhancing the effects of radiation on malignant cells. These compounds also accumulate in cells, where they act cytotoxins or imaging agents. However, whether these apply to cancer stem cells has not been sufficiently explored. Here we show that 2-nitroimidazole doranidazole potentiates radiation-induced DNA damage glioma (GSCs) and confers a significant survival benefit mice harboring GSC-derived...
Synovial sarcoma of the maxillary sinus: an extremely rare case with excellent response to chemotherapy Shin Saito,1 Hiroyuki Ozawa,1 Yuuichi Ikari,1 Nana Nakahara,1 Fumihiro Ito,2 Mariko Sekimizu,1 Junichi Fukada,3 Kaori Kameyama,4 Kaoru Ogawa1 1Department Otorhinolaryngology – Head and Neck Surgery, Keio University, School Medicine, 2Department NHO Tokyo Medical Center, 3Department Radiology, 4Department Pathology, Tokyo, Japan Abstract: This paper presents synovial arising from...
To prospectively use long-scan-time computed tomography (CT) to visualize the trajectory of tumor movements or internal target volume.The study was approved by institutional review board. Written informed consent obtained from participants after and role procedures were explained fully. During planning stereotactic radiation therapy for 10 patients (nine men, one woman; mean age, 77 years; range, 69-89 years) with small lung tumors (mean volume, 9.0 cm3; 3.6-24.9 cm3), fluoroscopic imaging,...
Image-based measurement of absorbed dose Ra-223 dichloride may be useful in predicting therapeutic outcome patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to more accurate than planar imaging terms lesion-based analysis. The aims this study were assess the feasibility and clinical usefulness SPECT. energy spectrum images a cylindrical phantom hot rod obtained determine collimator candidates window settings suitable for (basic A). Another...
We aimed to evaluate the efficacy and safety of 5-fluorouracil-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma (PDAC).This retrospective study investigated clinicopathological features > 5-year survival T3/T4 PDAC who underwent NACRT at our institute between 2003 2012.Seventeen eight borderline were included. The protocol treatment completion resection rates 92.0% 68.0%, respectively. Two failed complete...
Purpose: We investigated the incidences of pericardial and pleural effusions after definitive radiotherapy with or without concurrent chemotherapy were analyzed retrospectively. Methods: One hundred forty-seven patients esophageal cancer received chemoradiotherapy (CCR). Follow-up chest Computed Tomography scans reviewed to detect effusions. Adverse events graded according Radiation Therapy Oncology Group Common Toxicity Criteria. Results: The median follow-up was 34 (range, 6 84) months....
Abstract Background In patients with highly advanced gastric cancer, the recurrence rate remains high and prognosis disappointing. We previously reported a phase I study of neoadjuvant chemoradiotherapy S-1 plus weekly cisplatin. Although adequate safety efficacy were reported, myelosuppression was frequently observed, leading to treatment delay in several cases. To decrease toxicity improve efficacy, we planned modified chemotherapy regimen biweekly Methods Patients cancer lymph node...
Potentially lethal damage (PLD) and its repair (PLDR) were studied in confluent human fibroblasts by analyzing the kinetics of chromosome break rejoining after X-ray or heavy-ion exposures. Cells either held non-cycling G0 phase cell cycle for 12 h, forced to proliferate immediately irradiation. Fusion premature condensation (PCC) was combined with fluorescence situ hybridization (FISH) study chromosomal aberrations interphase. The culture condition had no impact on PCC breaks during h...
We investigated the usefulness of fusion image created by transrectal ultrasonography (TRUS) and large-bore computed tomography (CT) for predicting pubic arch interference (PAI) during prostate seed brachytherapy. The TRUS volume study was performed in 21 patients, followed patients lithotomy position. Then, we TRUS-CT images using a radiation planning treatment system. which outline largest were overlaid on CT with narrowest arch. PAI estimated right left separately classified to three...
A 71-year-old Japanese woman presented to the Department of Neurosurgery Keio University School Medicine (Tokyo, Japan) with a leiomyosarcoma originating in infratemporal fossa and an 85-mm metastasis right lung. Since pulmonary lesion was associated risk airway obstruction, radiation therapy (50 Gy/20 fractions) administered patient, which resulted remarkable tumor shrinkage. Subsequently, patient 800 mg/day pazopanib for 10 weeks, further reduction size. However, succumbed massive...
Abstract Cabazitaxel (CBZ) is approved for the treatment of docetaxel-resistant castration-resistant prostate cancer (CRPC). However, its efficacy against CRPC limited, and there are no effective treatments CBZ-resistant CRPC. This study explored optimal in post-cabazitaxel setting. PC3 (CBZ-sensitive) PC3CR cells (CBZ-resistant) were used this study. We performed silico drug screening candidate drugs that could reprogram gene expression signature cells. The vivo effect combination was...
The risk of stroke caused by dislodgment loose atheromatous plaque or mural emboli is increased cross-clamping the aorta. Some patients undergo descending thoracic aortic aneurysm repair with proximal between left common carotid artery and subclavian artery. objective this study was to determine influence in arteriosclerotic dissecting repair.Between May 1984 2003, 81 underwent elective surgery for distal arch To evaluate cross-clamping, were divided into two groups: who had undergone (group...
We analysed the repositioning accuracy of bite-plate fixations from serial QA-CT (quality-assurance CT) taken during course stereotactic radiotherapy. A total 72 series CT examinations 15 consecutive patients, who underwent radiotherapy for various intracranial tumours, were examined. Three or four scans obtained purpose QA right and left incus, as well crista galli. The coordinates centres incus top galli semi-automatically each scan. Positional displacements these anatomical reference...
We investigated long-term treatment outcomes and the feasibility of chemoradiotherapy consisting daily-low-dose 5-fluorouracil cisplatin (LDFP) chemotherapy plus radiotherapy for Stage I-II squamous cell esophageal cancer. Treatment records from 2000 through 2008 period were reviewed retrospectively. Fractionated was performed with a total dose 60 Gy delivered in 2 per fraction. LDFP chemotherapy, as continuous infusion 200 mg/m2 combined one hour 4 cisplatin, administered on same days...