A5102956408- Asthma and respiratory diseases
- Aquaculture disease management and microbiota
- Lymphatic System and Diseases
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Aquaculture Nutrition and Growth
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Diet and metabolism studies
- Nutrition and Health in Aging
- Spaceflight effects on biology
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Nutrition and Gastroenterology
- Receptor Mechanisms and Signaling
- Air Quality and Health Impacts
- Antifungal resistance and susceptibility
- Food Allergy and Anaphylaxis Research
- Birth, Development, and Health
- T-cell and B-cell Immunology
- Reproductive biology and impacts on aquatic species
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- Circadian rhythm and melatonin
- Marine Sponges and Natural Products
- Cardiac Arrest and Resuscitation
Baylor College of Medicine
2014-2025
Michael E. DeBakey VA Medical Center
2020
The University of Texas MD Anderson Cancer Center
1979-2015
Southwest Research Institute
2014
The University of Texas Health Science Center at Houston
2010
Swansea University
1993-2009
University of Wales
1994-1999
Marine Biological Association of the United Kingdom
1999
University of Aberdeen
1997-1998
Queen's University
1992-1994
Proteinases and the innate immune receptor Toll-like 4 (TLR4) are essential for expression of allergic inflammation diseases such as asthma. A mechanism that links these inflammatory mediators is explaining fundamental basis disease but has been elusive. Here, we demonstrate TLR4 activated by airway proteinase activity to initiate both antifungal immunity. These outcomes were induced cleavage clotting protein fibrinogen, yielding fibrinogen products acted ligands on epithelial cells...
MicroRNAs (miRNAs) are short, non-coding RNAs that target and silence protein coding genes through 3′-UTR elements. Evidence increasingly assigns an immunosuppressive role for miRNAs in immunity, but relatively few have been studied, overall understanding of the importance these regulatory transcripts complex <i>in vivo</i> systems is lacking. Here we applied multiple technologies to globally analyze miRNA expression function allergic lung disease, experimental model asthma. Deep sequencing...
Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses lung cancer remains unknown. Here, we show that nCB increased PD-L1
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of anti-Candida immunity remains unknown. We show that C. enters mouse from blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) candidalysin. Saps disrupt tight junction proteins blood-brain barrier (BBB) permit invasion. also hydrolyze amyloid precursor protein (APP) into β (Aβ)-like peptides bind Toll-like...
Duplication of the MECP2 gene in humans and mice results immune dysregulation due part to suppression IFN-γ production from T helper cells.
First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure death. Despite approved antiviral treatments, there is unmet need treatments that can improve outcomes in populations failure, including tobacco users with Chronic Obstructive Pulmonary Disease (COPD). Here we show the sialidase fusion protein, DAS181, reduced viral burden, mitigated inflammation, attenuated lung function loss, consistent broad-spectrum anti-influenza responses a...
Signal transducer and activator of transcription 6 (STAT6) transmits signals from cytokines IL-4 IL-13 is activated in allergic airway disease. We are developing phosphopeptide mimetics targeting the SH2 domain STAT6 to block recruitment phosphotyrosine residues on or receptors subsequent Tyr641 phosphorylation inhibit expression genes contributing asthma. Structure–affinity relationship studies showed that phosphopeptides based Tyr631 IL-4Rα bind with weak affinity STAT6, whereas replacing...
Abstract The eicosanoid generating potential of the brain, gills, skin, ovary, muscle, eye, liver, spleen, heart, and alimentary canal in rainbow trout, Oncorhynchus mykiss , was examined. All organs/tissues examined synthesized 12‐lipoxygenase products, 12‐hydroxyeicosatetraenoic acid (12‐HETE), 12‐hydroxyeicosapentaenoic (12‐HEPE), implying widespread nature this enzyme trout. Both prostaglandin E LTC were also found variable amounts organs, with greatest amount PGE gill. Leukotriene (LT)...
Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish murine model of unified eosinophilic inflammation, mice were challenged Aspergillus niger , sinonasal mucosa lung tissue evaluated by immunohistochemistry, flow cytometry, gene expression. Inhalation A conidia resulted in Th2-biased sinus inflammation that typifies allergic CRS. Gene network pathway analysis...
Ten cases of septic olecranon bursitis and two prepatellar were treated in the period from 1975 to 1980 with antibiotics percutaneous tube placement for suction-drainage local antibiotic irrigation. All patients had positive bacterial cultures: Staphylococcus aureus nine, beta-hemolytic Streptococcus two, epidermidis one. Intravenous antibiotics, suction-drainage, irrigation a solution 1% kanamycin 0.1% polymyxin controlled infection each case. The treatment averaged 19 days, compared 24...
Abstract Introduction Fungal airway infection (airway mycosis) is increasingly recognized as a cause of asthma and related disorders. However, prior controlled studies patients treated with antifungal antibiotics have produced conflicting results. Our objective to measure the effect therapy in moderate severe adult asthmatics positive fungal sputum cultures single center referral‐based academic practice. Methods We retrospectively evaluated 41 culture‐proven mycosis either terbinafine,...