A5100425045- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Proteomics Techniques and Applications
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Surgery and Microvascular Techniques
- Cancer Treatment and Pharmacology
- Mass Spectrometry Techniques and Applications
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- AI in cancer detection
- Bioinformatics and Genomic Networks
- Information Retrieval and Search Behavior
- Organizational and Employee Performance
- MRI in cancer diagnosis
- Analytical Chemistry and Chromatography
- Metal Extraction and Bioleaching
- Advanced Text Analysis Techniques
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Machine Learning in Bioinformatics
- Natural Products and Biological Research
- Advanced Breast Cancer Therapies
CHA University
2021-2024
CHA Gangnam Medical Center
2021-2024
Kyungpook National University
2023
Seoul National University
2008-2022
Weatherford College
2022
New Generation University College
2022
Bucheon St. Mary's Hospital
2018
Catholic University of Korea
2018
Korea Institute of Science and Technology
2014
Abraxis (United States)
2007
Abstract Mass spectrometry (MS) based proteomics is widely used for biomarker discovery. However, often, most candidates from discovery are discarded during the validation processes. Such discrepancies between and caused by several factors, mainly due to differences in analytical methodology experimental conditions. Here, we generated a peptide library which allows of biomarkers equal settings as process, thereby making transition more robust efficient. The initiated with list 3393 proteins...
PURPOSE Sentinel lymph node biopsy (SLNB) has become a standard axillary staging surgery for early breast cancer, and the proportion of patients requiring dissection (ALND) is decreasing. We aimed to evaluate association between number sentinel nodes (SLNs) retrieved risk lymphedema ipsilateral arm. METHODS Prospectively collected medical records 910 were reviewed. Lymphedema was defined as difference in circumference > 2 cm compared contralateral arm and/or having clinical treatment...
Currently, the standard screening tool for breast cancer is mammography. There have been many efforts to develop a blood-based diagnostic assay diagnosis; however, none approved clinical use at this time. The purpose of study was determine accuracy novel proteomic test aiding diagnosis in relatively large cohort patients.A using multiple reaction monitoring (MRM) measured by mass spectrometry quantify 3 peptides (apolipoprotein C-1, carbonic anhydrase 1, and neural cell adhesion molecule...
While the value of Ki-67 has been recognized in breast cancer, controversy also exists. The goal this study is to show prognostic according progesterone receptor (PgR) expression patients who have estrogen receptor- (ER-) positive, human epidermal growth factor 2- (HER2-) negative early cancer.The records nonmetastatic invasive cancer underwent surgery at a single institution between 2009 and 2012 were reviewed. Primary end point was recurrence-free survival (RFS), secondary overall (OS)....
Purpose This study was designed to verify the effectiveness of Mastocheck, a new diagnostic tool developed with proteomics techniques using plasma proteins. In addition, checked current state mammography used for breast cancer screening. Methods A total 305 cases were analyzed (normal 122, 183) and validation after Mastocheck development. First, screening mammograms normal patients pre-diagnosis reviewed retrospectively. The results compared newly blood test. Imaging tests blinded by...
TPS603 Background: The most important and well established benefit of neoadjuvant therapy for breast cancer patients is increased conservation rate. However, in ER-positive HER-2 negative cancer, the response to chemotherapy (NCT) not as good other subtype such or triple-negative cancer. In addition, with advancement multi-gene assay tools this subtype, adjuvant needed at all significant proportion subtype. Through a selective therapy, either endocrine using histopathologic markers 70-gene...
Abstract Background Mammography screening has been proven to detect breast cancer at an early stage and reduce mortality; however, it low accuracy in young women or with dense breasts. Blood-based diagnostic tools may overcome the limitations of mammography. This study assessed performance a three-protein signature patients suspicious lesions. Findings trial (MAST; KCT0004847) was prospective multicenter observational trial. Three-protein values were obtained using serum plasma from lesions...
Near-infrared (NIR) imaging with indocyanine green (ICG)-enhanced fluorescence is widely used in laparoscopic surgery. This study aimed to evaluate this technique's feasibility and usefulness intraoperatively assessing vascular perfusion a laparoscopically harvested omental flap.From March 2015 February 2016, we prospectively evaluated patients undergoing breast cancer surgery followed by immediate reconstruction using flap. After preparation of the pedicled graft, area graft was...
The oncoplastic breast-conserving surgery (OPS) technique, combined with the principles of oncological safety and plastic surgery, results in complete tumor resection while preserving natural appearance breast. purpose this study was to evaluate long-term after OPS compared conventional (BCS) for early breast cancer.The medical records patients who underwent cancer adjuvant radiation therapy at Seoul National University Hospital between 2011 2014 were reviewed. Ipsilateral recurrence...
Studies have suggested a potential role of patient's co-morbidity in determining the survival outcomes breast cancer. In this study, we examined long-term oncologic cancer patients who underwent curative surgery according to their pre-existing comorbid conditions and analyzed association between use adjuvant therapies.The medical records 2,501 for primary from June 2006 2010 were reviewed retrospectively. The classified into three groups preoperative ASA status determined by...
Purpose Neoadjuvant chemotherapy (NCT) is a treatment modality that increases the breast-conserving rate in breast cancer. This prospective study was performed to evaluate actual using NCT clinical setting single institution. Methods Between 2014 and 2015, 265 patients who were scheduled receive surgery enrolled this study. Patients classified into three groups based on immunohistochemical results of estrogen receptor (ER)/progesterone (PR) human epidermal growth factor 2 (HER2): ER or PR...
Abstract Background: Previously, three-protein signature (Mastocheck®, Bertis Inc.) from plasma has been launched to overcome the limitation of low accuracy mammography. In addition, nine-protein serum was newly developed improve as a blood-based diagnostic tool. This study aimed validate utility for breast cancer with comparison signature. Methods: A test using multiple reaction monitoring (MRM) by mass spectrometry quantify nine proteins (APOC1, CHL1, FN1, VWF, PPBP, CLU, PRDX6, PRG4, and...
This study examined the tea production and distribution by private sector in first half of Joseon era. After researching various government-issued geography sections, history records, poems, evidence was found. National sections listed 32-35 areas Gyeongnam Jeonra province, but other also produced teas according to poems. On hand, a certain region as area on national record whenin fact, it no longer. Teas were distributed shops, merchants, markets. In addition, some scholars temples shared...
Background: Computer-aided diagnosis (CAD) as an adjunct to breast ultrasonography (US) has been extensively developed using different imaging techniques help improve radiologists' diagnostic performance, particularly in distinguishing malignant from benign lesions. Additionally, quantitative variables can be obtained CAD. Objectives: The aim of this study was evaluate the usefulness CAD US by exploring performance and reporting data system (BI-RADS) descriptors variables. Patients Methods:...
Latissimus dorsi mini-flap (LDMF) reconstruction after breast-conserving surgery (BCS) is a useful volume replacement technique when large tumor located in the upper or outer portion of breast. However, few studies have reported impact LDMF on patients' quality life (QoL) and cosmesis compared with conventional BCS.We identified patients who underwent BCS without between 2010 2020 at single center. At least 1 year surgery, we prospectively administered BREAST-Q to assess QoL obtained breast...
Research on the metaverse has experienced significant growth in recent years, driven by advancements technology, thriving gaming industry, expansion of social media and virtual communities, economic prospects, captivating vision a new digital interface that transcends current internet environment. To uncover research themes within metaverse, we conducted comprehensive analysis trends this field using publications from Scopus, widely recognized extensively utilized scholarly database....
Based on the American College of Surgeons Oncology Group (ACOSOG)-Z0011, a useful nomogram has been constructed to identify patients who do not require intraoperative frozen sections evaluate sentinel lymph nodes in previous study. This study investigated developed by ultrasonography (US) and positron emission tomography (PET)/computed (CT) as modality. In training set, 89/1030 (8.6%) had three or more positive nodes. Larger tumor size, higher grade ultrasonographic ALN classification,...
3044 Background: Breast cancer is the most frequently diagnosed and leading cause of cancer-related deaths among women worldwide. Although screening mammography available, there an ongoing interest in improved early detection prognosis. And also, serum tumor marker levels, such as CA 15-3 others, may reflect disease progression recurrence, they have not proven to be sensitive for detection. Research investigating biomarkers detection, prognosis prediction treatment responses breast rapidly...
Purpose: Immunohistochemical (IHC) evaluation is important for the management of breast cancer. Cold ischemic time (CIT) may result in inaccurate IHC results. The aim this study was to investigate effect CIT on results invasive ductal carcinoma (IDC). Methods: We retrospectively reviewed records 316 patients diagnosed with IDC from February 2013 June at a single hospital Korea. clinicopathological characteristics and positivity estrogen receptor (ER), progesterone (PR), Ki-67, human...