A5005370949- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Pulmonary Hypertension Research and Treatments
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 and Mental Health
- Pharmacological Effects and Toxicity Studies
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Epilepsy research and treatment
- Asthma and respiratory diseases
- Circular RNAs in diseases
- Fungal Infections and Studies
- Neonatal Respiratory Health Research
- Schizophrenia research and treatment
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- COVID-19 epidemiological studies
University General Hospital Attikon
2008-2025
National and Kapodistrian University of Athens
2015-2024
University of Crete
1996-2022
University Hospital of Heraklion
2005-2017
Eginition Hospital
2017
Foundation for Research and Technology Hellas
2017
Athens Medical Center
2017
Democritus University of Thrace
2013
University of Ioannina
2010
Sotiria General Hospital
2010
The share of the elderly population is growing worldwide as life expectancy increases. Immunosenescence and comorbidities increase infectious diseases’ morbidity mortality in older adults. Here, we aimed to summarize latest findings on vaccines for against herpes zoster, influenza, respiratory syncytial virus (RSV), COVID-19, pneumococcal disease examine vaccine recommendation differences this age group Europe United States. PubMed was searched using keywords “elders” “vaccine” alongside...
ABSTRACT A sensitive multiplex PCR assay for single-tube amplification that detects simultaneous herpes simplex virus type 1 (HSV-1), 2 (HSV-2), varicella-zoster (VZV), human cytomegalovirus (CMV), and Epstein-Barr (EBV) is reported with particular emphasis on how the method was optimized carried out its sensitivity compared to previously described assays. The has been used a limited number of clinical samples must be thoroughly evaluated in context. total 86 cerebrospinal fluid (CSF)...
It is known that essential hypertension may be implicated in the development of cognitive impairment associated to microvascular disease brain. has been hypothesized increased arterial stiffness large arteries lead changes due pulsatile flow. Our study tests hypothesis artery and damage are related brain microcirculation as reflected by impaired function.We studied 110 nondiabetic patients aged 40-80 years (mean age 53.8 +/- 11.2 years, 57 men) with recently diagnosed stage I-II...
To investigate the clinical characteristics associated with presence of LSV at birth. Prospective 1:1 case-control study. Two tertiary neonatal units in Athens, Greece. Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within first 3 life, where was detected. Associations between and Both unmatched matched analyses stratifying study population by week were conducted. Two-sided p-values computed using likelihood ratio test. This included 166 participants (83...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by airflow limitation. It the fourth leading cause of death worldwide, responsible for 3.5 million deaths in 2021. The main symptoms include shortness breath, cough, sputum production, and wheezing. Beyond its physical impact, COPD also significantly affects mental health, with patients experiencing higher rates depression compared to general population. Depression contributes lower quality life,...
<i>Background/Aims:</i> The brain-derived neurotrophic factor (BDNF) levels in serum and the central nervous system are altered patients with schizophrenia, suggesting that changes expression of BDNF might contribute to disease pathophysiology. Long duration untreated psychosis (DUP) has been associated poorer prognosis schizophrenia. Such a relationship outcome may indicate neurodegenerative process have important implications for understanding pathophysiology...
Subclinical organ damage represents an intermediate stage in the continuum of vascular disease and a determinant overall cardiovascular risk. We investigated associations pulse wave velocity (PWV), ambulatory arterial stiffness index (AASI), office pressure (PP) with several target damages (TODs) newly diagnosed never-treated patients essential hypertension respect to their dipping profile.One hundred sixty-eight hypertensive recently I-II were evaluated relationship PWV, AASI, PP TOD...
Aim of this study was to investigate the association total and regional lean body mass (LBM) with cardiometabolic risk factors in healthy obese nonobese postmenopausal women.A 150 women (age 54 ± 7 years, BMI 29.6 5.8 kg/m2) underwent a comprehensive assessment risk, including metabolic syndrome (MS). Body composition analysis performed Dual-energy X-ray Absorptiometry, multiple height-adjusted indices LBM were evaluated.After controlling for age, diet, physical activity, fat mass, most...
The ABO blood groups, Lewis antigens, and secretor systems are important components of transfusion medicine. These interconnected have been also shown to be associated with differing susceptibility bacterial viral infections, likely as the result selection over course evolution constant tug war between humans infectious microbes. This comprehensive narrative review aimed explore literature present current state knowledge on reported associations ABO, Lewis, groups SARS-CoV-2 infection...
Endometrial cancer is the most common female genital and approximately 90% of cases are diagnosed while they still confined to uterus. However, frequency pattern pulmonary metastasis (PM) have not been studied systematically.From 1962 1989, 90 patients wit PM were identified by computerized search medical records 1,550 (5.8%) admitted Massachusetts General Hospital with diagnosis uterine cancer. The median age was 67 years (range from 42 88 years). histology neoplasms included 53...
Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia bipolar disorder, through their regulatory on the expression multiple genes. The rather rare co-morbidity is an old hypothesis which needs further research molecules that might exert oncosuppressive or oncogenic activity context disorders. pattern variety different was investigated patients (N = 6) suffering from termed control, with solid tumor 10) both 8). miRNA profiling performed whole...
Although amphotericin B-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully treat refractory invasive aspergillosis. So far, pharmacodynamic (PD) interactions have assessed with conventional in vitro tests, which do not mimic human serum concentrations and animal models using limited doses. We therefore simulated the concentration profiles of B voriconazole an dialysis/diffusion closed...
Combination therapy of voriconazole with an echinocandin is often employed in order to increase the efficacy monotherapy. Four clinical Aspergillus fumigatus isolates different vitro susceptibilities (MIC 0.125–2 mg/L) and anidulafungin (MEC 0.008–0.016 were tested pharmacokinetic/pharmacodynamic model simulating human serum concentrations standard dosages anidulafungin. Fungal growth was assessed using galactomannan production quantitative PCR. Drug determined bioassays. Pharmacodynamic...