A5015486918- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Bee Products Chemical Analysis
- Reproductive tract infections research
- Photodynamic Therapy Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical and Biological Ozone Research
- Genomics, phytochemicals, and oxidative stress
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Plant Pathogens and Fungal Diseases
- Cancer, Hypoxia, and Metabolism
- Medicinal Plants and Bioactive Compounds
- Seaweed-derived Bioactive Compounds
- Nanoplatforms for cancer theranostics
- Garlic and Onion Studies
- Tryptophan and brain disorders
- Oral microbiology and periodontitis research
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemistry Medicinal Plant Applications
- Cancer, Lipids, and Metabolism
- Mast cells and histamine
- Ginger and Zingiberaceae research
Universidade Estadual de Maringá
2016-2025
Florida Agricultural and Mechanical University
2016-2024
GTx (United States)
2019
The Nrf2-Keap1-ARE pathway is the principal regulator of antioxidant and phase II detoxification genes. Its activation increases expression cytoprotective proteins, protecting cells against infections. Nrf2 modulates virus-induced oxidative stress, ROS generation, disease pathogenesis, which are vital in viral life cycle. During respiratory infections, such as severe acute syndrome coronavirus 2 (SARS-CoV-2), an inflammatory process, stress epithelium lining activate transcription factor...
Recently, the cytotoxic effects of apigenin (4′,5,7‐trihydroxyflavone), particularly its marked inhibition cancer cell viability both in vitro and vivo, have attracted attention anticancer drug discovery field. Despite this, there are few studies cervical cancer, these mostly been conducted using HeLa cells. To evaluate possibility as a new therapeutic candidate for we evaluated comprehensive panel human cancer‐derived lines including (human papillomavirus/HPV 18‐positive), SiHa (HPV...
Vulvovaginal candidiasis (VVC) is one of the most common genital infections in women. The therapeutic arsenal remains restricted, and some alternatives to VVC treatment are being studied. present study evaluated influence a propolis extractive solution (PES) on biofilm production by Candida albicans isolated from patients with VVC. Susceptibility testing was used verify minimum inhibitory concentration (MIC) PES, fluconazole nystatin as controls. formation 29 vaginal isolates C. reference...
Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation BV-2 microglial cells. The results show that pre-treatment with decreased expression pro-inflammatory cytokines: G-CSF, IL1-α, MCP-5, MIP3α, and, higher effect in MIP3α. In RT-PCR assays, mRNA CHUK, NFκB1/p150, and IKBKE (NFƙB signaling), which may be associated neuropathology Alzheimer's disease. data inhibiting...
Chronic oxidative stress (OS) and inflammation are implicated in developing progressing neurodegenerative diseases (NDs). The chronic activation of microglia cells leads to the overproduction several substances, including nitric oxide reactive oxygen species, which can induce neurodegeneration. Natural compounds have recently been investigated for their potential protect from OS improve many disease-related conditions. Cardamonin (CD) is a bioactive compound plants, such as Alpinia...
Aim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves filamentation form inhibition were determined in cells. on biofilms was assessed through quantification CFUs. Results: ranging from 220 to 880 µg/ml, demonstrated higher efficiency C. albicans parapsilosis than tropicalis In addition, able prevent biofilm's formation eradicate their mature biofilms, coupled with a significant...
Background/Aim: Triple-negative breast cancer (TNBC) is the most aggressive subtype, predominant in African American women. In this study, antioxidant/anticancer activity of muscadine grape extracts and role their phenolic flavonoid contents exerting these properties were investigated TNBC cells. Materials Methods: Berry from genotypes for total content (TPC), (TFC), antioxidant capacity, anticancer effects using cell lines, representing Caucasians Americans. Results: The was associated with...
Biomaterials that effectively act in biological systems, as treatment and healing of damaged or lost tissues, must be able to mimic the properties body's natural tissues its various aspects (chemical, physical, mechanical surface). These characteristics influence cell adhesion proliferation are crucial for success which a biomaterial will required. In this context, electrospinning process has gained prominence obtaining fibers micro- nanometric sizes from polymeric solutions aiming produce...
We studied host factors that could predispose women to develop recurrent vulvovaginal candidiasis (RVVC), including glycemia, insulin resistance, chronic stress, antioxidant capacity, overall immune status, local inflammation and vaginal microbiota. The presence of yeasts in culture was screened 277 women, with or without signs symptoms VVC RVVC. an inflammatory process microbiota were analyzed through bacterioscopy cervical-vaginal cytology, respectively. Fasting-blood samples collected by...
Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. Moreover, sub-acute chronic inflammation is a contributor the pathology of diverse degenerative diseases (Parkinson's disease, Alzheimer's disease arthritis). Given known limitations Western medicine treat broad range related illness as well emergence antibiotic resistance, there renewed interest...
Aim: To evaluate the efficacy of photodynamic inactivation (PDI) mediated by hypericin encapsulated in P-123 copolymeric micelles (P123-Hyp) alone and combination with fluconazole (FLU) against planktonic cells biofilm formation Candida species Materials & methods: PDI was performed using P123-Hyp an LED device irradiance 3.0 mW/cm2 . Results: Most isolates (70%) were completely inhibited concentrations up to 2.0 μmol/l HYP light fluence 16.2 J/cm2. FLU-resistant strains had synergic effect...