A5018512127- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects and Toxicity Studies
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Bone health and osteoporosis research
- Muscle Physiology and Disorders
- Pancreatitis Pathology and Treatment
- TGF-β signaling in diseases
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Glycogen Storage Diseases and Myoclonus
- IL-33, ST2, and ILC Pathways
- Adrenal Hormones and Disorders
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Adrenal and Paraganglionic Tumors
- Bone and Dental Protein Studies
- Inflammasome and immune disorders
- Parathyroid Disorders and Treatments
New York University
2019-2025
Children's Hospital of Pittsburgh
2024
University of Pittsburgh
2024
Jackson Laboratory
2024
The University of Texas Health Science Center at Houston
2024
Cukurova University
2019-2022
Kahramanmaraş Sütçü İmam University
2017
Approximately 30-45% of patients with familial Mediterranean fever (FMF) have been reported to attacks despite colchicine treatment. Currently, data on the treatment colchicine-unresponsive or colchicine-intolerant FMF are limited; most promising alternatives seem be anti-interleukin-1 (anti-IL-1) agents. Here we report our experience off-label use anti-IL-1 agents in a large group patients.In all, 21 centers from different geographical regions Turkey were included current study. The medical...
<p dir="ltr">Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these induce various metabolic changes, including weight loss and impaired bone integrity. There is a significant gap in understanding SGLT2i-induced skeletal as SGLT2 not expressed osteoblasts or osteocytes, which use to remodel the matrix. We studied impact 1, 3, 6 months canagliflozin (CANA), an SGLT2i treatment, on skeleton...
Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these induce various metabolic changes, including weight loss and impaired bone integrity. There is a significant gap in understanding SGLT2i-induced skeletal as SGLT2 not expressed osteoblasts or osteocytes, which use to remodel the matrix. We studied impact 1, 3, 6 months canagliflozin (CANA), an SGLT2i treatment, on skeleton 6-month-old genetically...
<p dir="ltr">Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these induce various metabolic changes, including weight loss and impaired bone integrity. There is a significant gap in understanding SGLT2i-induced skeletal as SGLT2 not expressed osteoblasts or osteocytes, which use to remodel the matrix. We studied impact 1, 3, 6 months canagliflozin (CANA), an SGLT2i treatment, on skeleton...
Aging | doi:10.18632/aging.205147. Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R. Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A. Miller, David E. Harrison, John Strong, Mitchell B. Schaffler, Shoshana Yakar
Abstract Background Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, inflammation synovium. Methods We investigated prevalence primary OA aged, genetically diverse UM-HET3 mice. Articular cartilage (AC)...
Patients with type 1 diabetes mellitus (T1DM) exhibit reduced BMD and significant increases in fracture risk. Changes are attributed to blunted osteoblast activity inhibited bone remodeling, but these cannot fully explain the impaired integrity T1DM. The goal of this study was determine cellular mechanisms that contribute morphology composition Nonobese diabetic (NOD) mice were used, along μCT, histomorphometry, histology, Raman spectroscopy, RNAseq analyses several skeletal sites response...
Abstract Osteoarthritis (OA), the most prevalent joint disease, is a major cause of disability worldwide. Growth hormone (GH) has been suggested to play significant roles in maintaining articular chondrocyte function and ultimately cartilage (AC) homeostasis. In humans, age‐associated decline GH levels was hypothesized role etiology OA. We studied impact adult‐onset isolated deficiency (AOiGHD) on life span skeletal integrity including AC, 23‐ 30‐month‐old male female mice C57/BL6 genetic...
Bioactive free IGF-I is critically important for growth. The bioavailability of modulated by the IGF-binding proteins (IGFBPs) and their proteases, such as pregnancy-associated plasma protein-A2 (PAPP-A2). We have created a mouse model with specific mutation in PAPPA2 identified human PAPP-A2 deficiency. was introduced to genome via knock-in strategy, creating mice detectable protein levels Papp-a2 but without protease activities. found that Pappa2 led significant reductions body length...
ABSTRACT Absent in Melanoma (AIM) 2 is a gene that induced by interferon and acts as cytosolic sensor for double-stranded (ds) DNA. It forms the AIM2 inflammasome, leading to production of interleukin (IL)-1β IL-18. Our previous research demonstrated mice lacking exhibit spontaneous obesity, insulin resistance, inflammation adipose tissue. In this study, we aimed explore impact deletion on bone structure adult aged mice. Utilizing micro-computed tomography (micro-CT), discovered female...
Abstract A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this vivo, observing that GHv treatment male high-fat fed rats had several GH-like activities, but unlike GH lacked diabetogenic and lactogenic activities failed to increase IGF-1 or body length. Therefore, the current study conducted further characterize vivo a separate species GH-deficient model (GH-/- mice) with both sexes represented. GHv-treated GH-/-...
This study investigated the prevalence and progression of primary osteoarthritis (OA) in aged UM-HET3 mice. Using Osteoarthritis Research Society International (OARSI) scoring system, we assessed articular cartilage (AC) integrity 182 knee joints 22-25 months old Aged mice showed a high OA both sexes. Significant positive correlations were found between cumulative AC (cAC) scores synovitis sexes, osteophyte formation female Ectopic chondrogenesis did not show significant with cAC scores....
Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, inflammation synovium.
Fsp27 was previously identified as a lipid droplet-associated protein in adipocytes. Various studies have shown that it plays role the regulation of homeostasis adipose tissue and liver. However, its function muscle, which also accumulate metabolize fat, remains completely unknown. Our present study identifies novel muscle performance. Here, we demonstrate
Excess in growth hormone (GH) levels, seen patients with acromegaly, is associated increases fractures. This happens despite wider bones and independent of bone mineral density. We used the bovine GH (bGH) transgenic mice, which show constitutive excess insulin-like factor 1 (IGF-1) serum tissues, to study how lifelong IGF-1 affect skeletal integrity. Additionally, we crossed acid labile subunit (ALS) null (ALSKO) bGH mice reduce levels. Our findings indicate sexually dimorphic effects on...
Abstract Declines in mitochondrial content and impaired cytochrome c oxidase activity (complex IV) can result reduced energy metabolism increased levels of oxidants. Methylene blue (MB) is a well-established antioxidant that has been shown to improve function both vitro vivo settings. Mitoquinone (MitoQ) selective specifically targets mitochondria effectively reduces the accumulation reactive oxygen species (ROS) within cells. To investigate effect acute long-term administration MB on...
Pregnancy-associated plasma protein A2 (PAPP-A2) is a metalloproteinase which, by cleaving IGFBP-3 and IGFBP-5, releases free IGF-I from the ternary complexes regulates its bioavailability. PAPPA2 gene mutations (p.D643fs25* p.Ala1033Val) have recently been described in various members of two unrelated families. Affected patients short stature, moderate microcephaly, thin long bones, mildly decreased bone density, insulin resistance, elevated total but low [1].
<h3>Introduction</h3> Fanconi Bickel Syndrome (FBS) is a rare autosomal recessively inherited inborn error of metabolism due to impaired utilization glucose and galactose. The mutations the responsible gene <i>SLC2A2</i> cause defects in transport protein-2. Clinical findings are severe growth retardation, polyuria, polydipsia, hypophosphatemic rickets. Laboratory proximal renal tubular dysfunction, fasting hypoglycemia postprandial hyperglycemia leading diabetes, some cases even neonatal...
<h3>Introduction</h3> Phenylketonuria (PKU) is the most common and autosomal recessively inherited metabolic disease due to deficiency of phenylalanine hydroxylase (PAH). Elevated levels are not only toxic for children but also teratogenic fetus. Clinical findings maternal phenylketonuria (MPKU) intrauterine growth retardation, microcephaly, significant developmental delay, congenital cardiac anomalies, some other structural defects. Poorly diet control high blood causes this severe...
Fetus in fetu (FIF) is a rare anomaly resulting from abnormal embryogenesis.Patients often present with an abdominal mass.We report case of FIF initially diagnosed as lymphocyst fetal ultrasonography (USG) during prenatal screening.