A5072227313- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Bone Metabolism and Diseases
- Spaceflight effects on biology
- TGF-β signaling in diseases
- Multiple Myeloma Research and Treatments
- Avian ecology and behavior
- Gestational Diabetes Research and Management
- Pituitary Gland Disorders and Treatments
- Aerospace Engineering and Energy Systems
- Cancer Treatment and Pharmacology
- Evolution and Paleontology Studies
- Bone health and treatments
- Liver physiology and pathology
- Microbial Community Ecology and Physiology
- Sirtuins and Resveratrol in Medicine
- Bat Biology and Ecology Studies
- Geology and Paleoclimatology Research
- Adenosine and Purinergic Signaling
- Hematopoietic Stem Cell Transplantation
- Paleontology and Stratigraphy of Fossils
- Connective tissue disorders research
Museum of Vertebrate Zoology
2021
University of California, Berkeley
2016-2021
City College of New York
2020-2021
Beth Israel Deaconess Medical Center
2011-2018
Massachusetts General Hospital
2014
Harvard University
2014
Cornell University
2010
Abstract Sclerostin, a product of the SOST gene produced mainly by osteocytes, is potent negative regulator bone formation that appears to be responsive mechanical loading, with expression increasing following unloading. We tested ability murine sclerostin antibody (SclAbII) prevent loss in adult mice subjected hindlimb unloading (HLU) via tail suspension for 21 days. Mice (n = 11–17/group) were assigned control (CON, normal weight bearing) or HLU and injected either SclAbII (subcutaneously,...
Abstract Type 2 diabetes (T2D) incidence in adolescents is rising and may interfere with peak bone mass acquisition. We tested the effects of early-onset T2D on mass, microarchitecture, strength TALLYHO/JngJ mouse, which develops by 8 weeks age. assessed metabolism skeletal acquisition male SWR/J controls (n = 8–10/group) from 4 to 17 Tallyho mice were obese; had an approximately 2-fold higher leptin percentage body fat; lower mineral density vs SWR at all time points (P < .03 for...
The polar bear is the only living ursid with a fully carnivorous diet. Despite number of well-documented craniodental adaptations for diet seal flesh and blubber, molecular paleontological data indicate that this morphologically distinct species evolved less than million years ago from omnivorous brown bear. To better understand evolution dietary specialization, we used phylogenetic tests to estimate rate morphological specialization in bears. We then finite element analysis (FEA) compare...
Microbialites, which are organosedimentary structures formed by microbial communities through binding and trapping and/or in situ precipitation, have a wide array of distinctive morphologies long geologic record. The origin morphological variability is hotly debated; elucidating the cause or causes microfabric differences could provide insights into ecosystem functioning biogeochemistry during much Earth’s history. Although rare today, morphologically distinct, co-occurring extant...
Starvation induces low bone mass and high marrow adiposity in humans, but the underlying mechanisms are poorly understood. The adipokine leptin falls starvation, suggesting that hypoleptinemia may be a link between negative energy balance, fat accumulation, impaired skeletal acquisition. In case, treating mice with during caloric restriction (CR) should reduce adipose tissue (MAT) improve mass. To test this hypothesis, female C57Bl/6J were fed 30% CR or normal (N) diet from 5 to 10 weeks of...
The effects of obesity on bone metabolism are complex, and may be mediated by consumption a high fat diet and/or obesity-induced metabolic dysregulation. To test the hypothesis that both (HF) diet-induced disease independently decrease skeletal acquisition, we compared HF mass microarchitecture in two mouse strains: (DIO)-susceptible C57BL/6J (B6) DIO-resistant FVB/NJ (FVB). At 3 wks age weaned 120 female FVB B6 mice onto normal (N, 10% Kcal/fat) or (45% euthanized them at 6, 12 20 weeks (N...
Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety efficacy has been studied in adults where the growth plate is fused there no longitudinal bone little appositional growth. Although bisphosphonate use pediatric population was pioneered compassionate treatment of osteogenesis imperfecta, they being increasingly used prevention loss children at risk hyperresorptive loss. However, effect these agents on growing skeleton...
Maternal high-fat (HF) diet can alter offspring metabolism via perinatal developmental programming. This study tests the hypothesis that maternal HF also induces programming of bone mass and strength. We compared skeletal acquisition in pups from C57Bl/6J mice fed or normal preconception through lactation. Three-week-old male female (HF-N) mothers (N-N) were weaned onto diet. Outcomes at 14 26 weeks age included body mass, composition, whole-body mineral content (WBBMC) peripheral...
ABSTRACT During high-speed pursuit of prey, the cheetah (Acinonyx jubatus) has been observed to swing its tail while manoeuvring (e.g. turning or braking) but effect these complex motions is not well understood. This study demonstrates potential cheetah's long, furry impart torques and forces on body as a result aerodynamic effects, in addition well-known inertial effects. The first-order are quantified through wind tunnel testing it that fur nearly doubles effective frontal area without...
Abstract Somatopause refers to the gradual declines in growth hormone (GH) and insulin‐like factor‐1 throughout aging. To define how induced somatopause affects skeletal integrity, we used an inducible GH receptor knockout (iGHRKO) mouse model. Somatopause, globally at 6 months of age, resulted significantly more slender bones both male female iGHRKO mice. In males, was associated with progressive expansion marrow cavity leading significant thinning cortices, which compromised bone strength....
Migration is the primary strategy that temperate birds use to avoid overwintering under harsh conditions. As a consequence, migratory have evolved specific morphological features in their wings and skeleton. However, addition varying overall shape size, bone can also change at microstructural level by, for example, increasing its thickness. Such changes are critical preventing fracture damage repeated loading (fatigue), yet it not known whether behaviour influences microstructure. To address...
Excess in growth hormone (GH) levels, seen patients with acromegaly, is associated increases fractures. This happens despite wider bones and independent of bone mineral density. We used the bovine GH (bGH) transgenic mice, which show constitutive excess insulin-like factor 1 (IGF-1) serum tissues, to study how lifelong IGF-1 affect skeletal integrity. Additionally, we crossed acid labile subunit (ALS) null (ALSKO) bGH mice reduce levels. Our findings indicate sexually dimorphic effects on...