A5046886708- Macrophage Migration Inhibitory Factor
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Feeding Issues
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Eosinophilic Esophagitis
- Gut microbiota and health
- Tryptophan and brain disorders
- Clostridium difficile and Clostridium perfringens research
- Zoonotic diseases and public health
- Phytochemistry and Biological Activities
- Vaccine Coverage and Hesitancy
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
Universidade Federal do Rio de Janeiro
2015-2023
Disease tolerance is a defensive strategy that limits tissue damage during infection. Macrophage migration inhibitory factor (MIF)-deficient mice ( Mif-/- ) are protected in different models of infection and intestinal inflammation due to unclear disease mechanisms, whereas low disease-tolerant Il10-/- develop microbiota-dependent spontaneous gut inflammation. Here, we examined whether IL-10 required for the phenotype seen and, conversely, contribution MIF deficiency. While breeding...
Abstract Macrophage migration inhibitory factor (MIF) is present in high amounts the BALF and serum of asthmatic patients, contributing to pathogenesis experimental asthma induced by OVA mice. Whether MIF contributes physiopathology on a more complex relevant model has not been characterized. Mif ‐deficient ( −/− ) or WT mice treated with anti‐MIF antibody were challenged multiple times using house dust mite (HDM) extract intranasal route. HDM‐challenged presented decreased airway...
Abstract Background Natural products are an important source of bioproducts with pharmacological properties. Here we investigate the components leaves from M. tomentosa Benth. (Fritsch) (Chrysobalanaceae) and its effects on bacterial cell growth, biofilm production macrophage activity. Methods The effect different leaf extracts against growth was performed using microdilution method. most active extract analyzed by mass spectrometry, evaluated polystyrene plates. activity tested in RAW264.7...
The vast spectrum of clinical features COVID-19 keeps challenging scientists and clinicians. Low resistance to infection might result in long-term viral persistence, but the underlying mechanisms remain unclear. Here, we studied immune response immunocompetent patients with prolonged SARS-CoV-2 by immunophenotyping, cytokine serological analysis. Despite loads symptoms comparable regular mildly symptomatic patients, carriers displayed weaker systemic IFN-I responses fewer circulating pDCs NK...
Summary The vast spectrum of clinical features COVID-19 keeps challenging scientists and clinicians. Control pathogen load (host resistance) prevention tissue damage (disease tolerance) are essential for the outcome infectious diseases. Both low resistance high disease tolerance might result in long-term viral persistence, but underlying mechanisms remain unclear. Here, we studied immune response immunocompetent patients with prolonged SARS-CoV-2 infection by immunophenotyping, cytokine...