Victoria Cortes Bastos
A5019673270- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
Universidade Federal do Rio de Janeiro
2021-2023
Abstract ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 positive individuals where cases were defined as COVID-19 patients respiratory distress requiring oxygen support (N = 38) controls those mild to moderate symptoms the who did not need therapy along entire clinical course 175). mRNA evaluated in nasopharyngeal...
COVID-19 vaccines have prevented millions of deaths. Yet, a small fraction the population reports chronic debilitating condition after vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in Yale LISTEN study. Compared controls, exhibited differences immune profiles, including reduced circulating...
Current guidelines for patient isolation in COVID-19 cases recommend a symptom-based approach, averting the use of control real-time reverse transcription PCR (rRT-PCR) testing. However, we hypothesized that patients with persistently positive results by RT-PCR severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be potentially infectious prolonged time, even if immunocompetent and asymptomatic, which would demand longer social period than presently recommended. To test this...
The vast spectrum of clinical features COVID-19 keeps challenging scientists and clinicians. Low resistance to infection might result in long-term viral persistence, but the underlying mechanisms remain unclear. Here, we studied immune response immunocompetent patients with prolonged SARS-CoV-2 by immunophenotyping, cytokine serological analysis. Despite loads symptoms comparable regular mildly symptomatic patients, carriers displayed weaker systemic IFN-I responses fewer circulating pDCs NK...
Summary The vast spectrum of clinical features COVID-19 keeps challenging scientists and clinicians. Control pathogen load (host resistance) prevention tissue damage (disease tolerance) are essential for the outcome infectious diseases. Both low resistance high disease tolerance might result in long-term viral persistence, but underlying mechanisms remain unclear. Here, we studied immune response immunocompetent patients with prolonged SARS-CoV-2 infection by immunophenotyping, cytokine...